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DBF20 serine/threonine-protein kinase DBF20 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856227, updated on 29-Jun-2024

Summary

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Gene symbol
DBF20
Gene description
serine/threonine-protein kinase DBF20
Primary source
FungiDB:YPR111W
Locus tag
YPR111W
See related
SGD:S000006315; AllianceGenome:SGD:S000006315; VEuPathDB:YPR111W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including division septum assembly; exit from mitosis; and regulation of mRNA catabolic process. Located in cellular bud neck and spindle pole body. Orthologous to human LATS1 (large tumor suppressor kinase 1) and LATS2 (large tumor suppressor kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See DBF20 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (747306..749000)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Gld1p Neighboring gene DNA-directed RNA polymerase core subunit RPC40 Neighboring gene RNA-binding ribosome biosynthesis protein MRD1 Neighboring gene CDP-diacylglycerol--inositol 3-phosphatidyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Single-molecule mRNA decay measurements reveal promoter- regulated mRNA stability in yeast. Trcek T, et al. Cell, 2011 Dec 23. PMID 22196726, Free PMC Article
  2. The Dbf2 and Dbf20 protein kinases of budding yeast are activated after the metaphase to anaphase cell cycle transition. Toyn JH, et al. EMBO J, 1994 Mar 1. PMID 8131744, Free PMC Article
  3. The cell-cycle-regulated budding yeast gene DBF2, encoding a putative protein kinase, has a homologue that is not under cell-cycle control. Toyn JH, et al. Gene, 1991 Jul 31. PMID 1916278
  4. Asymmetric spindle pole localization of yeast Cdc15 kinase links mitotic exit and cytokinesis. Menssen R, et al. Curr Biol, 2001 Mar 6. PMID 11267871
  5. Spo12 is a limiting factor that interacts with the cell cycle protein kinases Dbf2 and Dbf20, which are involved in mitotic chromatid disjunction. Toyn JH, et al. Genetics, 1993 Dec. PMID 8307336, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in division septum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exit from mitosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cytokinesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in microtubule organizing center IEA
Inferred from Electronic Annotation
more info
  
is_active_in spindle pole body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase DBF20
NP_015436.1
  • Ser/Thr kinase involved in late nuclear division; one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; DBF20 has a paralog, DBF2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    747306..749000
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184208.1 → NP_015436.1  TPA: serine/threonine-protein kinase DBF20 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015436.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4B0, E9P8X8, P32328, Q06105
    UniProtKB/TrEMBL
    A0A8H4BVE3, B3LK75, B5VTQ1, N1NXQ2
    Conserved Domains (1) summary
    cd05600
    Location:157 → 539
    STKc_Sid2p_like; Catalytic domain of Fungal Sid2p-like Protein Serine/Threonine Kinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32328.2

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