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MRI1 S-methyl-5-thioribose-1-phosphate isomerase MRI1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856234, updated on 17-May-2024

Summary

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Gene symbol
MRI1
Gene description
S-methyl-5-thioribose-1-phosphate isomerase MRI1
Primary source
FungiDB:YPR118W
Locus tag
YPR118W
See related
SGD:S000006322; AllianceGenome:SGD:S000006322; VEuPathDB:YPR118W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables S-methyl-5-thioribose-1-phosphate isomerase activity. Involved in L-methionine salvage from methylthioadenosine. Located in cytoplasm and nucleus. Orthologous to human MRI1 (methylthioribose-1-phosphate isomerase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MRI1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (767752..768987)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Rrg8p Neighboring gene Hob2p Neighboring gene tRNA-Lys Neighboring gene B-type cyclin CLB2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Construction of sake yeast with low production of dimethyl trisulfide precursor by a self-cloning method. Ikeda Y, et al. J Biosci Bioeng, 2018 Apr. PMID 29331527
  2. Mutagenesis, breeding, and characterization of sake yeast strains with low production of dimethyl trisulfide precursor. Makimoto J, et al. J Biosci Bioeng, 2020 Dec. PMID 32800812
  3. Involvement of methionine salvage pathway genes of Saccharomyces cerevisiae in the production of precursor compounds of dimethyl trisulfide (DMTS). Wakabayashi K, et al. J Biosci Bioeng, 2013 Oct. PMID 23773701
  4. Crystal structure of yeast Ypr118w, a methylthioribose-1-phosphate isomerase related to regulatory eIF2B subunits. Bumann M, et al. J Biol Chem, 2004 Aug 27. PMID 15215245
  5. A complete inventory of all enzymes in the eukaryotic methionine salvage pathway. Pirkov I, et al. FEBS J, 2008 Aug. PMID 18625006

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables S-methyl-5-thioribose-1-phosphate isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables S-methyl-5-thioribose-1-phosphate isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables S-methyl-5-thioribose-1-phosphate isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-methionine salvage from S-adenosylmethionine IEA
Inferred from Electronic Annotation
more info
  
involved_in L-methionine salvage from methylthioadenosine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-methionine salvage from methylthioadenosine IEA
Inferred from Electronic Annotation
more info
  
involved_in L-methionine salvage from methylthioadenosine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
S-methyl-5-thioribose-1-phosphate isomerase MRI1
NP_015443.1
  • 5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    767752..768987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184215.1 → NP_015443.1  TPA: S-methyl-5-thioribose-1-phosphate isomerase MRI1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015443.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZWZ9, B3LK82, B5VTQ8, C7GXT0, C8ZJE0, D6W4B7, Q06489
    UniProtKB/TrEMBL
    A0A8H4F751, N1P2B9
    Conserved Domains (1) summary
    COG0182
    Location:1 → 411
    MtnA; Methylthioribose-1-phosphate isomerase (methionine salvage pathway), a paralog of eIF-2B alpha subunit [Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06489.1

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