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YPR147C bifunctional triacylglycerol lipase/ester hydrolase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856270, updated on 1-Aug-2024

Summary

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Gene symbol
YPR147C
Gene description
bifunctional triacylglycerol lipase/ester hydrolase
Primary source
FungiDB:YPR147C
Locus tag
YPR147C
See related
SGD:S000006351; AllianceGenome:SGD:S000006351; VEuPathDB:YPR147C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables triglyceride lipase activity. Involved in triglyceride catabolic process. Located in lipid droplet. Orthologous to human LDAH (lipid droplet associated hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See YPR147C in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (825645..826559, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene asparagine synthase (glutamine-hydrolyzing) 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Nce102p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular modeling, docking and dynamics analysis of lipid droplet associated enzyme Ypr147cp from Saccharomyces cerevisiae. Sesham K, et al. Bioinformation, 2021. PMID 34393428, Free PMC Article
  2. Saccharomyces cerevisiae lipid droplet associated enzyme Ypr147cp shows both TAG lipase and ester hydrolase activities. M NK, et al. J Gen Appl Microbiol, 2018 May 21. PMID 29491250
  3. High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation. Currie E, et al. J Lipid Res, 2014 Jul. PMID 24868093, Free PMC Article
  4. Global protein expression profiling of budding yeast in response to DNA damage. Lee MW, et al. Yeast, 2007 Mar. PMID 17351896
  5. Reconstitution and protein composition analysis of endocytic actin patches. Michelot A, et al. Curr Biol, 2010 Nov 9. PMID 21035341, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on ester bonds IDA
Inferred from Direct Assay
more info
 PubMed 
enables lipase activity IEA
Inferred from Electronic Annotation
more info
  
enables triglyceride lipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables triglyceride lipase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid storage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid storage IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
bifunctional triacylglycerol lipase/ester hydrolase
NP_015473.1
  • Bifunctional triacylglycerol lipase and short chain ester hydrolase; null mutant results in the accumulation of both triacylglycerol and fatty acids derived from neutral lipids and phospholipids as well as an increase in the quantity of lipid droplets; contains an alpha/beta hydrolase domain with a conserved GXSXG lipase motif; localizes to lipid droplets; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    825645..826559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184244.1 → NP_015473.1  TPA: bifunctional triacylglycerol lipase/ester hydrolase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015473.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4E4, Q06522
    UniProtKB/TrEMBL
    A6ZX23, B3LKA7, C8ZJH1, G2WPW0, N1NXU0
    Conserved Domains (1) summary
    pfam10230
    Location:30 → 292
    LIDHydrolase; Lipid-droplet associated hydrolase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06522.1

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