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PRP4 U4/U6-U5 snRNP complex subunit PRP4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856307, updated on 1-Aug-2024

Summary

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Gene symbol
PRP4
Gene description
U4/U6-U5 snRNP complex subunit PRP4
Primary source
FungiDB:YPR178W
Locus tag
YPR178W
See related
SGD:S000006382; AllianceGenome:SGD:S000006382; VEuPathDB:YPR178W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RNA4
Summary
Predicted to enable U4 snRNA binding activity and U6 snRNA binding activity. Involved in snoRNA splicing and spliceosomal conformational changes to generate catalytic conformation. Part of U4/U6 x U5 tri-snRNP complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa 70. Orthologous to human PRPF4 (pre-mRNA processing factor 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PRP4 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (892332..893729)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene DNA polymerase epsilon noncatalytic subunit Neighboring gene Rab geranylgeranyltransferase BET2 Neighboring gene Hda3p Neighboring gene E1 ubiquitin-activating protein AOS1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations within the yeast U4/U6 snRNP protein Prp4 affect a late stage of spliceosome assembly. Ayadi L, et al. RNA, 1997 Feb. PMID 9042946, Free PMC Article
  2. Mutational analysis of the PRP4 protein of Saccharomyces cerevisiae suggests domain structure and snRNP interactions. Hu J, et al. Nucleic Acids Res, 1994 May 11. PMID 8202378, Free PMC Article
  3. PRP4: a protein of the yeast U4/U6 small nuclear ribonucleoprotein particle. Banroques J, et al. Mol Cell Biol, 1989 Sep. PMID 2528687, Free PMC Article
  4. PRP4 (RNA4) from Saccharomyces cerevisiae: its gene product is associated with the U4/U6 small nuclear ribonucleoprotein particle. Bjørn SP, et al. Mol Cell Biol, 1989 Sep. PMID 2528686, Free PMC Article
  5. Domains of yeast U4 spliceosomal RNA required for PRP4 protein binding, snRNP-snRNP interactions, and pre-mRNA splicing in vivo. Bordonné R, et al. Genes Dev, 1990 Jul. PMID 2145195

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables U4 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables U6 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snoRNA splicing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spliceosomal conformational changes to generate catalytic conformation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
U4/U6-U5 snRNP complex subunit PRP4
NP_015504.1
  • Splicing factor; component of the U4/U6-U5 snRNP complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    892332..893729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184275.1 → NP_015504.1  TPA: U4/U6-U5 snRNP complex subunit PRP4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015504.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4H8, P20053
    UniProtKB/TrEMBL
    B3LKD7, B5VTV9, C8ZJK7
    Conserved Domains (3) summary
    cd00200
    Location:175 → 465
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:178 → 216
    7WD40; WD40 repeat [structural motif]
    pfam16515
    Location:128 → 175
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20053.1

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