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AOS1 E1 ubiquitin-activating protein AOS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856310, updated on 1-Aug-2024

Summary

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Gene symbol
AOS1
Gene description
E1 ubiquitin-activating protein AOS1
Primary source
FungiDB:YPR180W
Locus tag
YPR180W
See related
SGD:S000006384; AllianceGenome:SGD:S000006384; VEuPathDB:YPR180W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RHC31
Summary
Contributes to SUMO activating enzyme activity. Involved in protein sumoylation. Located in cytosol and nucleus. Part of SUMO activating enzyme complex. Orthologous to human SAE1 (SUMO1 activating enzyme subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See AOS1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (895961..897004)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene U4/U6-U5 snRNP complex subunit PRP4 Neighboring gene Hda3p Neighboring gene GTPase-activating protein SEC23 Neighboring gene mRNA splicing protein SMX3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Purification of SUMO conjugating enzymes and kinetic analysis of substrate conjugation. Yunus AA, et al. Methods Mol Biol, 2009. PMID 19107417, Free PMC Article
  2. The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer. Johnson ES, et al. EMBO J, 1997 Sep 15. PMID 9312010, Free PMC Article
  3. Crystal structure of UBA2(ufd)-Ubc9: insights into E1-E2 interactions in Sumo pathways. Wang J, et al. PLoS One, 2010 Dec 30. PMID 21209884, Free PMC Article
  4. A Chemical and Enzymatic Approach to Study Site-Specific Sumoylation. Albuquerque CP, et al. PLoS One, 2015. PMID 26633173, Free PMC Article
  5. SUMO conjugation and deconjugation. Schwienhorst I, et al. Mol Gen Genet, 2000 Jun. PMID 10905345

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to SUMO activating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-like modifier activating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein sumoylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of SUMO activating enzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SUMO activating enzyme complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E1 ubiquitin-activating protein AOS1
NP_015506.1
  • Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    895961..897004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184277.1 → NP_015506.1  TPA: E1 ubiquitin-activating protein AOS1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015506.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4I0, Q06624
    UniProtKB/TrEMBL
    B3LKD9, B5VTW1, C7GP62, C8ZJK9, N1P2H9
    Conserved Domains (1) summary
    cd01492
    Location:13 → 345
    Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06624.1

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