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HPA2 histone acetyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856323, updated on 1-Aug-2024

Summary

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Gene symbol
HPA2
Gene description
histone acetyltransferase
Primary source
FungiDB:YPR193C
Locus tag
YPR193C
See related
SGD:S000006397; AllianceGenome:SGD:S000006397; VEuPathDB:YPR193C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
KAT10
Summary
Enables N-acetyltransferase activity. Involved in protein acetylation. Located in cytoplasm. Orthologous to several human genes including SAT2 (spermidine/spermine N1-acetyltransferase family member 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See HPA2 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (922909..923379, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene ubiquinol--cytochrome-c reductase subunit 2 Neighboring gene Aqy1p Neighboring gene Opt2p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. D-amino acid N-acetyltransferase of Saccharomyces cerevisiae: a close homologue of histone acetyltransferase Hpa2p acting exclusively on free D-amino acids. Yow GY, et al. Arch Microbiol, 2004 Nov. PMID 15375647
  2. Crystal structure of the histone acetyltransferase Hpa2: A tetrameric member of the Gcn5-related N-acetyltransferase superfamily. Angus-Hill ML, et al. J Mol Biol, 1999 Dec 17. PMID 10600387
  3. Antagonistic Gcn5-Hda1 interactions revealed by mutations to the Anaphase Promoting Complex in yeast. Islam A, et al. Cell Div, 2011 Jun 8. PMID 21651791, Free PMC Article
  4. Genome-wide relationships between TAF1 and histone acetyltransferases in Saccharomyces cerevisiae. Durant M, et al. Mol Cell Biol, 2006 Apr. PMID 16537921, Free PMC Article
  5. Common industrial sake yeast strains have three copies of the AQY1-ARR3 region of chromosome XVI in their genomes. Ogihara F, et al. Yeast, 2008 Jun. PMID 18509847

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide-lysine-N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in protein acetylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein acetylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 

General protein information

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Preferred Names
histone acetyltransferase
NP_015519.1
  • Tetrameric histone acetyltransferase; has similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity; also acetylates polyamines

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    922909..923379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184290.1 → NP_015519.1  TPA: histone acetyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015519.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4J3, Q06592
    UniProtKB/TrEMBL
    A6ZX67, B3LKF1, C7GP74, C8ZJM2, G2WQ04, N1NVM7
    Conserved Domains (1) summary
    pfam00583
    Location:22 → 144
    Acetyltransf_1; Acetyltransferase (GNAT) family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06592.1

Gene LinkOut

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