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RIM4 Rim4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856361, updated on 1-Aug-2024

Summary

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Gene symbol
RIM4
Gene description
Rim4p
Primary source
FungiDB:YHL024W
Locus tag
YHL024W
See related
SGD:S000001016; AllianceGenome:SGD:S000001016; VEuPathDB:YHL024W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA binding activity. Involved in premeiotic DNA replication; reciprocal meiotic recombination; and sporulation resulting in formation of a cellular spore. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RIM4 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (56649..58790)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Snf6p Neighboring gene Npr3p Neighboring gene tRNA-His

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Meiotic Cells Counteract Programmed Retrotransposon Activation via RNA-Binding Translational Repressor Assemblies. Laureau R, et al. Dev Cell, 2021 Jan 11. PMID 33278343, Free PMC Article
  2. Autophagy of an Amyloid-like Translational Repressor Regulates Meiotic Exit. Wang F, et al. Dev Cell, 2020 Jan 27. PMID 31991104, Free PMC Article
  3. A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern. Berchowitz LE, et al. Genes Dev, 2013 Oct 1. PMID 24115771, Free PMC Article
  4. Phosphorylation-Mediated Clearance of Amyloid-like Assemblies in Meiosis. Carpenter K, et al. Dev Cell, 2018 May 7. PMID 29738715, Free PMC Article
  5. Regulated Formation of an Amyloid-like Translational Repressor Governs Gametogenesis. Berchowitz LE, et al. Cell, 2015 Oct 8. PMID 26411291, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Assembly and function of the amyloid-like translational repressor Rim4 is coupled with nutrient conditions.
    Title: Assembly and function of the amyloid-like translational repressor Rim4 is coupled with nutrient conditions.
  2. Regulation of Rim4 distribution, function, and stability during meiosis by PKA, Cdc14, and 14-3-3 proteins.
    Title: Regulation of Rim4 distribution, function, and stability during meiosis by PKA, Cdc14, and 14-3-3 proteins.
  3. identify the protein kinase Ime2 to bring about Rim4 clearance via phosphorylation of Rim4's intrinsically disordered region
    Title: Phosphorylation-Mediated Clearance of Amyloid-like Assemblies in Meiosis.
  4. Rim4 forms amyloid-like aggregates and that it is the amyloid-like form of Rim4 that is the active, translationally repressive form of the protein; data further show that Rim4 aggregation is a developmentally regulated process; at the onset of meiosis II, Rim4 aggregates are abruptly degraded allowing translation to commence.
    Title: Regulated Formation of an Amyloid-like Translational Repressor Governs Gametogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in premeiotic DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
involved_in sporulation resulting in formation of a cellular spore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rim4p
NP_011839.1
  • Putative RNA-binding protein; involved in regulation of early and middle sporulation genes; forms amyloid-like aggregates under starvation that are active in translational repression

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    56649..58790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179104.1 → NP_011839.1  TPA: Rim4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011839.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKU4, E9P8V3, P38741
    UniProtKB/TrEMBL
    G2WF42, N1P9G0
    Conserved Domains (6) summary
    COG0724
    Location:1 → 191
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    TIGR01622
    Location:300 → 378
    SF-CC1; splicing factor, CC1-like family
    pfam14179
    Location:615 → 669
    YppG; YppG-like protein
    cd00590
    Location:176 → 242
    RRM_SF; RNA recognition motif (RRM) superfamily
    cd12453
    Location:91 → 176
    RRM1_RIM4_like; RNA recognition motif 1 (RRM1) found in yeast meiotic activator RIM4 and similar proteins
    cd12454
    Location:343 → 420
    RRM2_RIM4_like; RNA recognition motif 2 (RRM2) found in yeast meiotic activator RIM4 and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38741.1

Gene LinkOut

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