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[ Saccharomyces cerevisiae S288C ]

Gene ID: 856381, updated on 11-Sep-2024

Summary

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Primary source
SGD:S000001000
Locus tag
YHL008C
See related
AllianceGenome:SGD:S000001000; FungiDB:YHL008C; VEuPathDB:YHL008C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables small molecule sensor activity. Involved in chloride transport and regulation of chloride transport. Located in fungal-type vacuole. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (92627..94510, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene tRNA-Val Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene mitogen-activated protein kinase kinase kinase kinase STE20 Neighboring gene Shu1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chloride homeostasis in Saccharomyces cerevisiae: high affinity influx, V-ATPase-dependent sequestration, and identification of a candidate Cl- sensor. Jennings ML, et al. J Gen Physiol, 2008 Apr. PMID 18378800, Free PMC Article
  2. The putative monocarboxylate permeases of the yeast Saccharomyces cerevisiae do not transport monocarboxylic acids across the plasma membrane. Makuc J, et al. Yeast, 2001 Sep 15. PMID 11536335
  3. The Rtt106 histone chaperone is functionally linked to transcription elongation and is involved in the regulation of spurious transcription from cryptic promoters in yeast. Imbeault D, et al. J Biol Chem, 2008 Oct 10. PMID 18708354
  4. Whi3, an S. cerevisiae RNA-binding protein, is a component of stress granules that regulates levels of its target mRNAs. Holmes KJ, et al. PLoS One, 2013. PMID 24386330, Free PMC Article
  5. Genome-wide protein interaction screens reveal functional networks involving Sm-like proteins. Fromont-Racine M, et al. Yeast, 2000 Jun 30. PMID 10900456, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion in Saccharomyces cerevisiae strongly reduces the Cl- influx.
    Title: Chloride homeostasis in Saccharomyces cerevisiae: high affinity influx, V-ATPase-dependent sequestration, and identification of a candidate Cl- sensor.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables high-affinity secondary active nitrite transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small molecule sensor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chloride transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nitrate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nitrite transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of chloride transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in fungal-type vacuole HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
NP_011855.1
  • hypothetical protein; may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    92627..94510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179088.1 → NP_011855.1  TPA: uncharacterized protein YHL008C [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011855.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKQ7, P38750
    Conserved Domains (1) summary
    COG2116
    Location:3 → 269
    FocA; Formate/nitrite transporter FocA, FNT family [Inorganic ion transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38750.1

Gene LinkOut

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