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RPL14B [ Saccharomyces cerevisiae S288C ]

Gene ID: 856388, updated on 11-Sep-2024

Summary

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Official Symbol
RPL14B
Primary source
SGD:S000000993
Locus tag
YHL001W
See related
AllianceGenome:SGD:S000000993; FungiDB:YHL001W; VEuPathDB:YHL001W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA binding activity. Predicted to be involved in ribosomal large subunit biogenesis. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Orthologous to human RPL14 (ribosomal protein L14). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VIII
Exon count:
2
Sequence:
Chromosome: VIII; NC_001140.6 (104277..105091)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene sphingosine N-acyltransferase LAG1 Neighboring gene ESCRT-0 subunit protein HSE1 Neighboring gene oxysterol-binding protein related protein OSH7 Neighboring gene ubiquinol--cytochrome-c reductase subunit 10

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ribosomal protein L14 contributes to the early assembly of 60S ribosomal subunits in Saccharomyces cerevisiae. Espinar-Marchena F, et al. Nucleic Acids Res, 2018 May 18. PMID 29788267, Free PMC Article
  2. Ubiquitin release from eL40 is required for cytoplasmic maturation and function of 60S ribosomal subunits in Saccharomyces cerevisiae. Martín-Villanueva S, et al. FEBS J, 2020 Jan. PMID 31306551
  3. Identification of a 57S translation complex containing closed-loop factors and the 60S ribosome subunit. Denis CL, et al. Sci Rep, 2018 Jul 31. PMID 30065356, Free PMC Article
  4. A single N(1)-methyladenosine on the large ribosomal subunit rRNA impacts locally its structure and the translation of key metabolic enzymes. Sharma S, et al. Sci Rep, 2018 Aug 9. PMID 30093689, Free PMC Article
  5. Binding of proteins from the large ribosomal subunits to 5.8 S rRNA of Saccharomyces cerevisiae. Lee JC, et al. J Biol Chem, 1983 Jan 25. PMID 6337137

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Assembly of L14 into early pre-60S r-particles is required for the progression of 27SA pre-rRNA processing.
    Title: Ribosomal protein L14 contributes to the early assembly of 60S ribosomal subunits in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IC
Inferred by Curator
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in maturation of LSU-rRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal 60S subunit protein L14B
NP_011862.1
  • Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14B has a paralog, RPL14A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    104277..105091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179081.1 → NP_011862.1  TPA: ribosomal 60S subunit protein L14B [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011862.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKR3, P38754
    UniProtKB/TrEMBL
    A6ZSQ1, A6ZZW0, B3LR79, C8ZA65, G2WI26, N1P1G0
    Conserved Domains (2) summary
    cd06088
    Location:15 → 89
    KOW_RPL14; KOW motif of Ribosomal Protein L14
    pfam01929
    Location:54 → 128
    Ribosomal_L14e; Ribosomal protein L14
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38754.1

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