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STP2 Stp2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856397, updated on 17-May-2024

Summary

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Gene symbol
STP2
Gene description
Stp2p
Primary source
FungiDB:YHR006W
Locus tag
YHR006W
See related
SGD:S000001048; AllianceGenome:SGD:S000001048; VEuPathDB:YHR006W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See STP2 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (117814..119439)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene protein transporter TIM10 Neighboring gene tRNA-Thr Neighboring gene sterol 14-demethylase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Discovery, validation, and genetic dissection of transcription factor binding sites by comparative and functional genomics. Gertz J, et al. Genome Res, 2005 Aug. PMID 16077013, Free PMC Article
  2. Receptor-mediated endoproteolytic activation of two transcription factors in yeast. Andréasson C, et al. Genes Dev, 2002 Dec 15. PMID 12502738, Free PMC Article
  3. Asi1 is an inner nuclear membrane protein that restricts promoter access of two latent transcription factors. Boban M, et al. J Cell Biol, 2006 Jun 5. PMID 16735580, Free PMC Article
  4. The N-terminal regulatory domain of Stp1p is modular and, fused to an artificial transcription factor, confers full Ssy1p-Ptr3p-Ssy5p sensor control. Andréasson C, et al. Mol Cell Biol, 2004 Sep. PMID 15314160, Free PMC Article
  5. Novel function of transcription factor Uga3 as an activator of branched-chain amino acid permease BAP2 gene expression. Muñoz SA, et al. Microbiology (Reading), 2020 Jan. PMID 31625834

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tup1p bound to the promoter region of TAT1 and TAT2 genes that were dependent on STP1 and STP2 (encoding DNA-binding activator proteins) for expression.
    Title: Yeast Cyc8p and Tup1p proteins function as coactivators for transcription of Stp1/2p-dependent amino acid transporter genes.
  2. Differential regulation of transcription factors Stp1 and Stp2 in the Ssy1-Ptr3-Ssy5 amino acid sensing pathway.
    Title: Differential regulation of transcription factors Stp1 and Stp2 in the Ssy1-Ptr3-Ssy5 amino acid sensing pathway.
  3. post-whole genome duplication co-conservation of the STP1 and STP2 genes was favored by functional divergence of their products, likely conferring to cells an increased ability to adapt to various amino acid supply conditions.
    Title: Amino acid signaling in yeast: post-genome duplication divergence of the Stp1 and Stp2 transcription factors.
  4. Dal81 indiscriminately amplifies the transactivation potential of both full-length and processed Stp1 and Stp2 by facilitating promoter binding.
    Title: Dal81 enhances Stp1- and Stp2-dependent transcription necessitating negative modulation by inner nuclear membrane protein Asi1 in Saccharomyces cerevisiae.
  5. Asi1, Asi2, and Asi3 work together to maintain the latent properties of transcription factors Stp1 and Stp2
    Title: Inner nuclear membrane proteins Asi1, Asi2, and Asi3 function in concert to maintain the latent properties of transcription factors Stp1 and Stp2.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Stp2p
NP_011870.1
  • Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    117814..119439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179136.1 → NP_011870.1  TPA: Stp2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011870.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKV0, E9P956, P38704
    UniProtKB/TrEMBL
    A0A8H4C171, B3LSC6, C8ZA73
    Conserved Domains (2) summary
    sd00017
    Location:206 → 226
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:204 → 226
    zf-C2H2; Zinc finger, C2H2 type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38704.1

Gene LinkOut

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