MYO1 myosin 1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: MYO1
Gene description: myosin 1
Primary source: FungiDB:YHR023W
Locus tag: YHR023W
See related: SGD:S000001065; AllianceGenome:SGD:S000001065; VEuPathDB:YHR023W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables myosin II light chain binding activity. Involved in mitotic cytokinesis and septum digestion after cytokinesis. Located in cellular bud neck contractile ring. Part of incipient cellular bud site and myosin II complex. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); blood platelet disease (multiple); cardiomyopathy (multiple); congenital heart disease (multiple); and muscle tissue disease (multiple). Orthologous to several human genes including MYH10 (myosin heavy chain 10); MYH15 (myosin heavy chain 15); and MYH7 (myosin heavy chain 7). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MYO1 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (151666..157452)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myo1 plays a major role in the septin-dependent Mlc1 localization to the division site before cytokinesis, whereas the formin Bni1 plays a major role in the actin filament-dependent Mlc1 localization during cytokinesis.
Title: Myosin‑II heavy chain and formin mediate the targeting of myosin essential light chain to the division site before and during cytokinesis.
myosin-mediated coupling between actin filaments and the base of endocytic sites is essential for allowing actin polymerization to drive membrane invagination
Title: An Engineered Minimal WASP-Myosin Fusion Protein Reveals Essential Functions for Endocytosis.
Deletion of MYO1 impairs the cluster formation of Ire1.
Title: F-actin and a type-II myosin are required for efficient clustering of the ER stress sensor Ire1.
Yeast myosin-II (Myo1p) and myosin-V (Myo2p) accommodate the reduced N-terminal charge density of yeast actin, showing greater activity with yeast over muscle actin
Title: Functional adaptation between yeast actin and its cognate myosin motors.
Results establish a biphasic targeting mechanism for Myo1 and highlights the role of the contractile actomyosin ring in cytokinesis beyond force generation.
Title: Biphasic targeting and cleavage furrow ingression directed by the tail of a myosin II.
TEDS site phosphorylation of the yeast myosins I is required for ligand-induced but not for constitutive endocytosis of Ste2p
Title: TEDS site phosphorylation of the yeast myosins I is required for ligand-induced but not for constitutive endocytosis of the G protein-coupled receptor Ste2p.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables myosin II light chain binding	IPI Inferred from Physical Interaction more info	PubMed
enables myosin light chain binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mitotic actomyosin contractile ring assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic actomyosin contractile ring contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic actomyosin contractile ring contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in primary cell septum biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to mitotic actomyosin contractile ring	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to mitotic actomyosin contractile ring	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in septum digestion after cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud neck contractile ring	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in incipient cellular bud site	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic actomyosin contractile ring	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin II complex	IPI Inferred from Physical Interaction more info	PubMed
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: myosin 1

NP_011888.1

Type II myosin heavy chain; required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

151666..157452

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179153.1 → NP_011888.1 TPA: myosin 1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011888.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DKX0, P08964

UniProtKB/TrEMBL

A6ZSS9, G2WF94

Conserved Domains (2) summary

COG1196
Location:1534 → 1890

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5022
Location:2 → 1691

COG5022; Myosin heavy chain [General function prediction only]