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YAP1801 Yap1801p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856566, updated on 10-Oct-2024

Summary

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Official Symbol
YAP1801
Official Full Name
Yap1801p
Primary source
SGD:S000001204
Locus tag
YHR161C
See related
AllianceGenome:SGD:S000001204; FungiDB:YHR161C; VEuPathDB:YHR161C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables clathrin binding activity. Involved in endocytosis. Located in cellular bud neck and prospore membrane. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human PICALM (phosphatidylinositol binding clathrin assembly protein) and SNAP91 (synaptosome associated protein 91). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See YAP1801 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (420373..422286, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Tda11p Neighboring gene Pex18p Neighboring gene mitochondrial pyruvate carrier Neighboring gene 6-phosphogluconolactonase SOL3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The function of yeast epsin and Ede1 ubiquitin-binding domains during receptor internalization. Dores MR, et al. Traffic, 2010 Jan. PMID 19903324, Free PMC Article
  2. Interaction between Epsin/Yap180 adaptors and the scaffolds Ede1/Pan1 is required for endocytosis. Maldonado-Báez L, et al. Mol Biol Cell, 2008 Jul. PMID 18448668, Free PMC Article
  3. The Sla2p talin domain plays a role in endocytosis in Saccharomyces cerevisiae. Baggett JJ, et al. Genetics, 2003 Dec. PMID 14704157, Free PMC Article
  4. Distinct roles for plasma membrane PtdIns(4)P and PtdIns(4,5)P(2) during receptor-mediated endocytosis in yeast. Yamamoto W, et al. J Cell Sci, 2018 Jan 4. PMID 29192062
  5. Sla1p serves as the targeting signal recognition factor for NPFX(1,2)D-mediated endocytosis. Howard JP, et al. J Cell Biol, 2002 Apr 15. PMID 11940605, Free PMC Article

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The conserved protein adaptors CALM/AP180 and FCHo1/2 cooperatively recruit Eps15 to promote the initiation of clathrin-mediated endocytosis in yeast.
    Title: The conserved protein adaptors CALM/AP180 and FCHo1/2 cooperatively recruit Eps15 to promote the initiation of clathrin-mediated endocytosis in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables clathrin binding IEA
Inferred from Electronic Annotation
more info
  
enables clathrin heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in clathrin coat assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in clathrin-dependent endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in vesicle budding from membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cellular bud IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
is_active_in clathrin-coated pit IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in prospore membrane HDA PubMed 

General protein information

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Preferred Names
Yap1801p
NP_012031.1
  • Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    420373..422286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179292.1 → NP_012031.1  TPA: Yap1801p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012031.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLB0, P38856
    UniProtKB/TrEMBL
    C8Z9V8, N1P4T8
    Conserved Domains (1) summary
    pfam07651
    Location:3 → 269
    ANTH; ANTH domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38856.1

Gene LinkOut

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