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RGD3 Rgd3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856588, updated on 4-Aug-2024

Summary

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Gene symbol
RGD3
Gene description
Rgd3p
Primary source
FungiDB:YHR182W
Locus tag
YHR182W
See related
SGD:S000001225; AllianceGenome:SGD:S000001225; VEuPathDB:YHR182W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activator activity. Involved in positive regulation of GTPase activity. Acts upstream of or within establishment or maintenance of cell polarity. Located in cytoplasmic vesicle membrane. Is active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RGD3 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (468219..470576)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene tRNA-Thr Neighboring gene Svp26p Neighboring gene phosphogluconate dehydrogenase (decarboxylating) GND1 Neighboring gene Ssp1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast Rgd3 is a phospho-regulated F-BAR-containing RhoGAP involved in the regulation of Rho3 distribution and cell morphology. Gingras RM, et al. Mol Biol Cell, 2020 Nov 1. PMID 32941095, Free PMC Article
  2. Reverse recruitment: the Nup84 nuclear pore subcomplex mediates Rap1/Gcr1/Gcr2 transcriptional activation. Menon BB, et al. Proc Natl Acad Sci U S A, 2005 Apr 19. PMID 15817685, Free PMC Article
  3. Endosome and Golgi-associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism. Schmidt O, et al. EMBO J, 2019 Aug 1. PMID 31368600, Free PMC Article
  4. Yeast Saccharomyces cerevisiae adiponectin receptor homolog Izh2 is involved in the regulation of zinc, phospholipid and pH homeostasis. Mattiazzi Ušaj M, et al. Metallomics, 2015 Sep. PMID 26067383
  5. Genetic interaction network of the Saccharomyces cerevisiae type 1 phosphatase Glc7. Logan MR, et al. BMC Genomics, 2008 Jul 15. PMID 18627629, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within establishment or maintenance of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cellular bud tip HDA PubMed 
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Rgd3p
NP_012052.1
  • GTPase activating protein (GAP) for Rho3p, involved in cell polarity green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    468219..470576
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179313.1 → NP_012052.1  TPA: Rgd3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012052.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLD0, P38870
    UniProtKB/TrEMBL
    A6ZT88, N1P2H8
    Conserved Domains (1) summary
    cl02570
    Location:492 → 646
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38870.1

Gene LinkOut

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