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DLD3 D-lactate dehydrogenase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856638, updated on 2-Nov-2024

Summary

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Official Symbol
DLD3
Official Full Name
D-lactate dehydrogenase
Primary source
SGD:S000000797
Locus tag
YEL071W
See related
AllianceGenome:SGD:S000000797; FungiDB:YEL071W; VEuPathDB:YEL071W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables (D)-2-hydroxyglutarate-pyruvate transhydrogenase activity; D-lactate dehydrogenase (cytochrome) activity; and FAD binding activity. Involved in filamentous growth and lactate biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 1. Orthologous to human D2HGDH (D-2-hydroxyglutarate dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See DLD3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (16355..17845)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rmd6p Neighboring gene mannitol dehydrogenase DSF1 Neighboring gene hexose transporter HXT13

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mks1p is required for negative regulation of retrograde gene expression in Saccharomyces cerevisiae but does not affect nitrogen catabolite repression-sensitive gene expression. Tate JJ, et al. J Biol Chem, 2002 Jun 7. PMID 11923302, Free PMC Article
  2. A transcriptome analysis of isoamyl alcohol-induced filamentation in yeast reveals a novel role for Gre2p as isovaleraldehyde reductase. Hauser M, et al. FEMS Yeast Res, 2007 Jan. PMID 16999827
  3. Kinetic properties of yeast D(-)-lactic cytochrome c reductase. NYGAARD AP. J Biol Chem, 1961 Jul. PMID 13729967
  4. Signalling between mitochondria and the nucleus regulates the expression of a new D-lactate dehydrogenase activity in yeast. Chelstowska A, et al. Yeast, 1999 Sep 30. PMID 10509019
  5. Quantitative Proteomics Combined with Two Genetic Strategies for Screening Substrates of Ubiquitin Ligase Hrt3. Lan Q, et al. J Proteome Res, 2020 Jan 3. PMID 31789040

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dld2 and Dld3, both currently annotated as D-lactate dehydrogenases, efficiently oxidized d-2-hydroxyglutarate to alpha-ketoglutarate.
    Title: Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples Its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables (D)-2-hydroxyglutarate-pyruvate transhydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables (D)-2-hydroxyglutarate-pyruvate transhydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables D-lactate dehydrogenase (cytochrome) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-lactate dehydrogenase (cytochrome) activity IEA
Inferred from Electronic Annotation
more info
  
enables FAD binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on CH-OH group of donors IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in filamentous growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lactate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
D-lactate dehydrogenase
NP_010843.1
  • 2-hydroxyglutarate transhydrogenase, and minor D-lactate dehydrogenase; converts D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate in the presence of FAD, with concomitant reduction of pyruvate to D-lactate; minor lactate dehydrogenase activity; component of the retrograde regulon that consists of genes whose expression are stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source; located in the cytoplasm

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    16355..17845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178886.1 → NP_010843.1  TPA: D-lactate dehydrogenase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010843.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLI0, P39976
    UniProtKB/TrEMBL
    A6ZQN2, B3LRU9, B5VH67, C7GQ34, C8ZFV1, G2WCG3, N1P7B4
    Conserved Domains (1) summary
    COG0277
    Location:34 → 496
    GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39976.1

Gene LinkOut

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