NUG1 RNA-binding GTPase NUG1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: NUG1
Official Full Name: RNA-binding GTPase NUG1
Primary source: SGD:S000000808
Locus tag: YER006W
See related: AllianceGenome:SGD:S000000808; FungiDB:YER006W; VEuPathDB:YER006W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables GTPase activity and RNA binding activity. Involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and ribosomal large subunit export from nucleus. Located in nucleolus. Part of preribosome, large subunit precursor. Orthologous to several human genes including GNL3 (G protein nucleolar 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See NUG1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (162723..164285)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nug1 associates with pre-60 S subunits via its essential N-terminal RNA-binding domain and exerts a non-essential regulative role in pre-60 S subunit biogenesis via its central GTPase domain
Title: The NUG1 GTPase reveals and N-terminal RNA-binding domain that is essential for association with 60 S pre-ribosomal particles.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	HDA more info	PubMed

Process	Evidence Code	Pubs
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in ribosomal large subunit export from nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ribosomal large subunit export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of preribosome, large subunit precursor	IGI Inferred from Genetic Interaction more info	PubMed

General protein information

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Preferred Names: RNA-binding GTPase NUG1

NP_010921.1

GTPase that associates with nuclear 60S pre-ribosomes; required for export of 60S ribosomal subunits from the nucleus

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

162723..164285

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178897.1 → NP_010921.1 TPA: RNA-binding GTPase NUG1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010921.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLQ2, P40010

UniProtKB/TrEMBL

A6ZQV2, B3LS17, C8Z704, G2WCN6, N1P5F6

Conserved Domains (2) summary

COG1161
Location:162 → 481

RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]

pfam08701
Location:15 → 88

GN3L_Grn1; GNL3L/Grn1 putative GTPase