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YAT2 carnitine O-acetyltransferase YAT2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856745, updated on 29-Jun-2024

Summary

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Gene symbol
YAT2
Gene description
carnitine O-acetyltransferase YAT2
Primary source
FungiDB:YER024W
Locus tag
YER024W
See related
SGD:S000000826; AllianceGenome:SGD:S000000826; VEuPathDB:YER024W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables carnitine O-acetyltransferase activity. Involved in alcohol metabolic process and carnitine metabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See YAT2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (202192..204963)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Srb4p Neighboring gene pyrroline-5-carboxylate reductase Neighboring gene translation initiation factor eIF2 subunit gamma Neighboring gene tRNA-His

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Carnitine and carnitine acetyltransferases in the yeast Saccharomyces cerevisiae: a role for carnitine in stress protection. Franken J, et al. Curr Genet, 2008 Jun. PMID 18427809
  2. Carnitine-dependent metabolic activities in Saccharomyces cerevisiae: three carnitine acetyltransferases are essential in a carnitine-dependent strain. Swiegers JH, et al. Yeast, 2001 May. PMID 11329169
  3. Requirements for Carnitine Shuttle-Mediated Translocation of Mitochondrial Acetyl Moieties to the Yeast Cytosol. van Rossum HM, et al. mBio, 2016 May 3. PMID 27143389, Free PMC Article
  4. Whole genome sequencing of Saccharomyces cerevisiae: from genotype to phenotype for improved metabolic engineering applications. Otero JM, et al. BMC Genomics, 2010 Dec 22. PMID 21176163, Free PMC Article
  5. Alternative reactions at the interface of glycolysis and citric acid cycle in Saccharomyces cerevisiae. van Rossum HM, et al. FEMS Yeast Res, 2016 May. PMID 26895788, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables carnitine O-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carnitine O-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables carnitine O-acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in alcohol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in carnitine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carnitine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
carnitine O-acetyltransferase YAT2
NP_010941.1
  • Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    202192..204963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178915.1 → NP_010941.1  TPA: carnitine O-acetyltransferase YAT2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010941.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLS3, P40017
    UniProtKB/TrEMBL
    A0A8H8ULN6, G2WCQ7
    Conserved Domains (1) summary
    pfam00755
    Location:23 → 733
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40017.1

Gene LinkOut

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