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EDC2 Edc2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856757, updated on 29-Jun-2024

Summary

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Gene symbol
EDC2
Gene description
Edc2p
Primary source
FungiDB:YER035W
Locus tag
YER035W
See related
SGD:S000000837; AllianceGenome:SGD:S000000837; VEuPathDB:YER035W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mRNA binding activity. Involved in deadenylation-dependent decapping of nuclear-transcribed mRNA and positive regulation of translation in response to stress. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See EDC2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (222639..223076)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Zrg8p Neighboring gene uncharacterized protein Neighboring gene ATP-binding cassette family ATPase ARB1 Neighboring gene bifunctional nucleotidase/lysophosphatidic acid phosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Enhancer of decapping proteins 1 and 2 are important for translation during heat stress in Saccharomyces cerevisiae. Neef DW, et al. Mol Microbiol, 2009 Sep. PMID 19682251, Free PMC Article
  2. The enhancer of decapping proteins, Edc1p and Edc2p, bind RNA and stimulate the activity of the decapping enzyme. Schwartz D, et al. RNA, 2003 Feb. PMID 12554867, Free PMC Article
  3. Dcp1 links coactivators of mRNA decapping to Dcp2 by proline recognition. Borja MS, et al. RNA, 2011 Feb. PMID 21148770, Free PMC Article
  4. Analysis of recombinant yeast decapping enzyme. Steiger M, et al. RNA, 2003 Feb. PMID 12554866, Free PMC Article
  5. Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae. Dunckley T, et al. Genetics, 2001 Jan. PMID 11139489, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In this report the authors show that strains lacking Edc2, as well as the paralogous protein Edc1, are compromised for growth under persistent heat stress.
    Title: Enhancer of decapping proteins 1 and 2 are important for translation during heat stress in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of translation in response to stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Edc2p
NP_010952.3
  • RNA-binding protein that directly activates mRNA decapping; binds mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein increases in abundance and relocalizes to nucleolus and to nuclear foci upon DNA replication stress; EDC2 has a paralog, EDC1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    222639..223076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178926.3 → NP_010952.3  TPA: Edc2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010952.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLT4, P40023
    UniProtKB/TrEMBL
    A0A6A5Q026, A6ZQY4, B3LS47, C7GSI2, C8Z737, G2WCR8, N1P6V7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40023.1

Gene LinkOut

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