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SHC1 Shc1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856832, updated on 18-Sep-2024

Summary

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Official Symbol
SHC1
Official Full Name
Shc1p
Primary source
SGD:S000000898
Locus tag
YER096W
See related
AllianceGenome:SGD:S000000898; FungiDB:YER096W; VEuPathDB:YER096W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables enzyme activator activity. Involved in ascospore formation and chitin biosynthetic process. Located in prospore membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SHC1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (351698..353236)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene proteasome core particle subunit beta 3 Neighboring gene recombinase RAD51 Neighboring gene tRNA-Glu Neighboring gene putative ubiquitin-specific protease UBP9

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SHC1, a high pH inducible gene required for growth at alkaline pH in Saccharomyces cerevisiae. Hong SK, et al. Biochem Biophys Res Commun, 1999 Feb 5. PMID 10082665
  2. Control of chitin synthesis through Shc1p, a functional homologue of Chs4p specifically induced during sporulation. Sanz M, et al. Mol Microbiol, 2002 Mar. PMID 11918806
  3. Long-Chain Polyprenols Promote Spore Wall Formation in Saccharomyces cerevisiae. Hoffmann R, et al. Genetics, 2017 Dec. PMID 28978675, Free PMC Article
  4. Saccharomyces cerevisiae Sps1p regulates trafficking of enzymes required for spore wall synthesis. Iwamoto MA, et al. Eukaryot Cell, 2005 Mar. PMID 15755916, Free PMC Article
  5. Dissection of a complex phenotype by functional genomics reveals roles for the yeast cyclin-dependent protein kinase Pho85 in stress adaptation and cell integrity. Huang D, et al. Mol Cell Biol, 2002 Jul. PMID 12077337, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables enzyme activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme activator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ascospore formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chitin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chitin biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in fungal-type cell wall organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in prospore membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Shc1p
NP_011022.1
  • Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    351698..353236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178987.1 → NP_011022.1  TPA: Shc1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011022.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM04, P39000
    UniProtKB/TrEMBL
    B3LRL5, C7GRT0, C8Z7B5
    Conserved Domains (3) summary
    smart00671
    Location:354 → 389
    SEL1; Sel1-like repeats
    COG0790
    Location:304 → 493
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:302 → 330
    SLR; SLR repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39000.1

Gene LinkOut

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