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MAG1 DNA-3-methyladenine glycosylase II [ Saccharomyces cerevisiae S288C ]

Gene ID: 856885, updated on 1-Aug-2024

Summary

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Gene symbol
MAG1
Gene description
DNA-3-methyladenine glycosylase II
Primary source
FungiDB:YER142C
Locus tag
YER142C
See related
SGD:S000000944; AllianceGenome:SGD:S000000944; VEuPathDB:YER142C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MMS5
Summary
Enables DNA-3-methyladenine glycosylase activity and damaged DNA binding activity. Involved in DNA dealkylation involved in DNA repair and base-excision repair, AP site formation. Predicted to be part of protein-DNA complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MAG1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (455146..456036, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Emp65p Neighboring gene Cox15p Neighboring gene Ddi1p Neighboring gene putative ubiquitin-specific protease UBP5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Harnessing mutagenic homologous recombination for targeted mutagenesis in vivo by TaGTEAM. Finney-Manchester SP, et al. Nucleic Acids Res, 2013 May. PMID 23470991, Free PMC Article
  2. Substrate specificity and sequence-dependent activity of the Saccharomyces cerevisiae 3-methyladenine DNA glycosylase (Mag). Lingaraju GM, et al. DNA Repair (Amst), 2008 Jun 1. PMID 18472311, Free PMC Article
  3. Effects of substrate specificity on initiating the base excision repair of N-methylpurines by variant human 3-methyladenine DNA glycosylases. Connor EE, et al. Chem Res Toxicol, 2005 Jan. PMID 15651853
  4. Generation of a strong mutator phenotype in yeast by imbalanced base excision repair. Glassner BJ, et al. Proc Natl Acad Sci U S A, 1998 Aug 18. PMID 9707589, Free PMC Article
  5. Protection against chloroethylnitrosourea cytotoxicity by eukaryotic 3-methyladenine DNA glycosylase. Matijasevic Z, et al. Proc Natl Acad Sci U S A, 1993 Dec 15. PMID 8265637, Free PMC Article

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA-3-methyladenine glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-3-methyladenine glycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-3-methyladenine glycosylase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-3-methylguanine glycosylase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-7-methyladenine glycosylase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-7-methylguanine glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-7-methylguanine glycosylase activity IEA
Inferred from Electronic Annotation
more info
  
enables alkylated DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alkylbase DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alkylbase DNA N-glycosylase activity IEA
Inferred from Electronic Annotation
more info
  
enables damaged DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA alkylation repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA alkylation repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in base-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in base-excision repair, AP site formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in base-excision repair, AP site formation IEA
Inferred from Electronic Annotation
more info
  
involved_in base-excision repair, AP site formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in base-excision repair, AP site formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-DNA complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA-3-methyladenine glycosylase II
NP_011069.1
  • 3-methyl-adenine DNA glycosylase; initiates base excision repair (BER) by removing damaged bases to create abasic sites that are subsequently repaired; expansion of BER repair removes alkylated bases resulting from alkylating agent-induced DNA damage, compensating for the lack of DNA repair by oxidative dealkylation; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    455146..456036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179032.1 → NP_011069.1  TPA: DNA-3-methyladenine glycosylase II [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011069.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM49, P22134
    UniProtKB/TrEMBL
    A6ZR99, B3LRQ5, B5VHR7, C7GQ54, C8Z7G2, N1P763
    Conserved Domains (1) summary
    COG0122
    Location:1 → 291
    AlkA; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and repair]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22134.1

Gene LinkOut

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