BEM2 GTPase-activating protein BEM2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: BEM2
Gene description: GTPase-activating protein BEM2
Primary source: FungiDB:YER155C
Locus tag: YER155C
See related: SGD:S000000957; AllianceGenome:SGD:S000000957; VEuPathDB:YER155C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: IPL2; SUP9; TSL1
Summary: Enables GTPase activator activity. Involved in actin cytoskeleton organization; mitotic morphogenesis checkpoint signaling; and negative regulation of Rho protein signal transduction. Located in several cellular components, including cell cortex; cellular bud tip; and mating projection tip. Part of incipient cellular bud site. Orthologous to human ARHGAP12 (Rho GTPase activating protein 12) and ARHGAP27 (Rho GTPase activating protein 27). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See BEM2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (476345..482848, complement)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bem2 might be a novel GTPase-activating protein for Rho4 in Saccharomyces cerevisiae.
Title: Control of polarized growth by the Rho family GTPase Rho4 in budding yeast: requirement of the N-terminal extension of Rho4 and regulation by the Rho GTPase-activating protein Bem2.
Bem2p and Bem3p may function as global inhibitors of Cdc42p activation during G1, and their inactivation by the Cdc28p/Cln kinase contributes to site-specific activation of Cdc42p at bud emergence
Title: Phosphorylation of Bem2p and Bem3p may contribute to local activation of Cdc42p at bud emergence.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	HDA more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic morphogenesis checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Rho protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud	IEA Inferred from Electronic Annotation more info
located_in cellular bud tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in incipient cellular bud site	IDA Inferred from Direct Assay more info	PubMed
located_in mating projection tip	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in prospore membrane	HDA more info	PubMed

General protein information

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Preferred Names: GTPase-activating protein BEM2

NP_011082.3

Rho GTPase activating protein (RhoGAP); contains RhoGAP activity specific for both Rho1p and Cdc42p, and potentially Rho4p; acts with the RhoGAP Bem3p to negatively regulate Cdc42p-dependent signal transduction; involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence and for the morphogenesis checkpoint in response to actin depolymerization; localizes to sites of polarized growth and the plasma membrane

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

476345..482848 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179045.3 → NP_011082.3 TPA: GTPase-activating protein BEM2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011082.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DM62, P39960

UniProtKB/TrEMBL

A0A8H8UM19, C7GQ41, N1P5E3

Conserved Domains (4) summary

smart00147
Location:592 → 860

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

pfam00169
Location:1877 → 1948

PH; PH domain

pfam00620
Location:1981 → 2134

RhoGAP; RhoGAP domain

cl02520
Location:1120 → 1291

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...