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ISC10 Isc10p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856927, updated on 1-Aug-2024

Summary

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Gene symbol
ISC10
Gene description
Isc10p
Primary source
FungiDB:YER180C
Locus tag
YER180C
See related
SGD:S000000982; AllianceGenome:SGD:S000000982; VEuPathDB:YER180C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mitogen-activated protein kinase binding activity and protein kinase inhibitor activity. Involved in ascospore formation. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ISC10 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (549724..550527, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase (acetyl-transferring) subunit E1 alpha Neighboring gene recombinase DMC1 Neighboring gene Slo1p Neighboring gene tRNA-Ile

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of a yeast gene that is homologous with a meiosis-specific cDNA from a plant. Kobayashi T, et al. Mol Gen Genet, 1993 Feb. PMID 8455558
  2. Isc10, an inhibitor of the Smk1 MAPK, prevents activation loop autophosphorylation and substrate phosphorylation through separate mechanisms. Rimal A, et al. J Biol Chem, 2022 Oct. PMID 36063999, Free PMC Article
  3. Isc10, an Inhibitor That Links the Anaphase-Promoting Complex to a Meiosis-Specific Mitogen-Activated Protein Kinase. Rimal A, et al. Mol Cell Biol, 2020 Jul 29. PMID 32423992, Free PMC Article
  4. Histone Acetylation, Not Stoichiometry, Regulates Linker Histone Binding in Saccharomyces cerevisiae. Lawrence MBD, et al. Genetics, 2017 Sep. PMID 28739661, Free PMC Article
  5. The nucleotide sequence of Saccharomyces cerevisiae chromosome V. Dietrich FS, et al. Nature, 1997 May 29. PMID 9169868, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Isc10, an Inhibitor That Links the Anaphase-Promoting Complex to a Meiosis-Specific Mitogen-Activated Protein Kinase.
    Title: Isc10, an Inhibitor That Links the Anaphase-Promoting Complex to a Meiosis-Specific Mitogen-Activated Protein Kinase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables mitogen-activated protein kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in ascospore formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
Isc10p
NP_011107.1
  • Meiosis-specific MAPK inhibitor; binds Smk1p during meiosis I; links APC/C-Ama1 to Smk1p activation; required for sporulation; transcript is induced 7.5 hr after induction of meiosis; Isc10p is ubiquitylated and degraded in an Ama1p-dependent manner upon completion of meiosis II

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    549724..550527 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179070.1 → NP_011107.1  TPA: Isc10p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011107.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM89, P32645
    UniProtKB/TrEMBL
    G2WD67
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32645.1

Gene LinkOut

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