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phyA prolyl 4-hydroxylase [ Dictyostelium discoideum AX4 ]

Gene ID: 8621207, updated on 17-May-2024

Summary

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Gene symbol
phyA
Gene description
prolyl 4-hydroxylase
Primary source
dictyBase:DDB_G0277759
Locus tag
DDB_G0277759
See related
AmoebaDB:DDB_G0277759; VEuPathDB:DDB_G0277759
Gene type
protein coding
RNA name
prolyl 4-hydroxylase
RefSeq status
PROVISIONAL
Organism
Dictyostelium discoideum AX4 (strain: AX4)
Lineage
Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium
Old locus tag
DDBDRAFT_0169393; DDBDRAFT_0231040; DDB_0169393; DDB_0231040
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Genomic context

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Location:
chromosome: 2
Exon count:
3
Sequence:
Chromosome: 2; NC_007088.5 (8457984..8459054)

Chromosome 2 - NC_007088.5Genomic Context describing neighboring genes Neighboring gene DNA repair metallo-beta-lactamase domain-containing protein Neighboring gene hypothetical protein Neighboring gene dolichyl-phosphate-glucose alpha-1,2-glucosyltransferase Neighboring gene solute carrier family 2 member protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007088.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Prolyl 4-hydroxylase-1 mediates O2 signaling during development of Dictyostelium. West CM, et al. Development, 2007 Sep. PMID 17699611
  2. The Skp1 prolyl hydroxylase from Dictyostelium is related to the hypoxia-inducible factor-alpha class of animal prolyl 4-hydroxylases. van der Wel H, et al. J Biol Chem, 2005 Apr 15. PMID 15705570
  3. Analysis of Skp1 glycosylation and nuclear enrichment in Dictyostelium. Sassi S, et al. Glycobiology, 2001 Apr. PMID 11358877
  4. Requirements for Skp1 processing by cytosolic prolyl 4(trans)-hydroxylase and α-N-acetylglucosaminyltransferase enzymes involved in O₂ signaling in dictyostelium. van der Wel H, et al. Biochemistry, 2011 Mar 15. PMID 21247092, Free PMC Article
  5. Novel regulation of Skp1 by the Dictyostelium AgtA α-galactosyltransferase involves the Skp1-binding activity of its WD40 repeat domain. Schafer CM, et al. J Biol Chem, 2014 Mar 28. PMID 24550398, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by dictyBase

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-proline 4-dioxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidyl-proline dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in SCF complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within culmination involved in sorocarp development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oxygen metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Names
prolyl 4-hydroxylase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007088.5 Reference assembly

    Range
    8457984..8459054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_637404.1 → XP_642496.1  prolyl 4-hydroxylase [Dictyostelium discoideum AX4]

    See identical proteins and their annotated locations for XP_642496.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q54Z57, Q86KR9
    Conserved Domains (1) summary
    pfam13640
    Location:177 → 284
    2OG-FeII_Oxy_3; 2OG-Fe(II) oxygenase superfamily
Nucleotide Protein
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