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STX10 syntaxin 10 [ Homo sapiens (human) ]

Gene ID: 8677, updated on 10-Dec-2024

Summary

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Official Symbol
STX10provided by HGNC
Official Full Name
syntaxin 10provided by HGNC
Primary source
HGNC:HGNC:11428
See related
Ensembl:ENSG00000104915 MIM:603765; AllianceGenome:HGNC:11428
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SYN10; hsyn10
Summary
This gene belongs to the syntaxin family and encodes a soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE). The encoded protein is involved in docking and fusion events at the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Expression
Ubiquitous expression in bone marrow (RPKM 17.6), spleen (RPKM 14.3) and 25 other tissues See more
Orthologs
all
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Genomic context

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See STX10 in Genome Data Viewer
Location:
19p13.13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (13144058..13150375, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (13269272..13275588, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (13254872..13261189, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 14065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:13220465-13220965 Neighboring gene tRNA methyltransferase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10192 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10193 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:13230123-13230624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:13230625-13231125 Neighboring gene nucleus accumbens associated 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:13234142-13234801 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:13247773-13248692 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10195 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10196 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14113 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14114 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:13263956-13264839 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14115 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10199 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10200 Neighboring gene immediate early response 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14120 Neighboring gene ribosomal protein L12 pseudogene 42

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Syntaxin 10: a member of the syntaxin family localized to the trans-Golgi network. Tang BL, et al. Biochem Biophys Res Commun, 1998 Jan 14. PMID 9446797
  2. The trans-Golgi SNARE syntaxin 10 is required for optimal development of Chlamydia trachomatis. Lucas AL, et al. Front Cell Infect Microbiol, 2015. PMID 26442221, Free PMC Article
  3. Structural basis for the interaction of the Golgi-Associated Retrograde Protein Complex with the t-SNARE Syntaxin 6. Abascal-Palacios G, et al. Structure, 2013 Sep 3. PMID 23932592, Free PMC Article
  4. Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1. Martín-Martín B, et al. J Leukoc Biol, 1999 Mar. PMID 10080545
  5. Trans-Golgi network syntaxin 10 functions distinctly from syntaxins 6 and 16. Wang Y, et al. Mol Membr Biol, 2005 Jul-Aug. PMID 16154903

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables syntaxin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in early endosome to Golgi transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network membrane TAS
Traceable Author Statement
more info
  
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
syntaxin-10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271609.2 → NP_001258538.1  syntaxin-10 isoform 2

    See identical proteins and their annotated locations for NP_001258538.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC011446, BC095459, BM830816, BM847745, CD364936
    Consensus CDS
    CCDS62570.1
    UniProtKB/TrEMBL
    X6R2W0
    Related
    ENSP00000242770.5, ENST00000242770.9
    Conserved Domains (2) summary
    pfam09177
    Location:13 → 103
    Syntaxin-6_N; Syntaxin 6, N-terminal
    cl22856
    Location:160 → 192
    SNARE; SNARE motif

  2. NM_001271610.2 → NP_001258539.1  syntaxin-10 isoform 3

    See identical proteins and their annotated locations for NP_001258539.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC011446, AY778966, BM830816, BM847745, CD364936
    Consensus CDS
    CCDS62569.1
    UniProtKB/TrEMBL
    K7EIY4, Q5U8S2
    Related
    ENSP00000465398.1, ENST00000589083.5
    Conserved Domains (2) summary
    cd15851
    Location:160 → 225
    SNARE_Syntaxin6; SNARE motif of syntaxin 6
    pfam09177
    Location:13 → 103
    Syntaxin-6_N; Syntaxin 6, N-terminal

  3. NM_001271611.2 → NP_001258540.1  syntaxin-10 isoform 4

    See identical proteins and their annotated locations for NP_001258540.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses two alternate splice sites and lacks an internal exon, resulting in the loss of an in-frame segment in the coding region, compared to variant 1. This results in a shorter isoform (4), compared to isoform 1.
    Source sequence(s)
    AC011446, BC017237, BM830816, BM847745, CD364936
    Consensus CDS
    CCDS62571.1
    UniProtKB/Swiss-Prot
    O60499
    Related
    ENSP00000339350.4, ENST00000343587.9
    Conserved Domains (2) summary
    cd15851
    Location:111 → 176
    SNARE_Syntaxin6; SNARE motif of syntaxin 6
    pfam09177
    Location:13 → 77
    Syntaxin-6_N; Syntaxin 6, N-terminal

  4. NM_003765.3 → NP_003756.1  syntaxin-10 isoform 1

    See identical proteins and their annotated locations for NP_003756.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC011446, AF035531, BM830816, BM847745, CD364936
    Consensus CDS
    CCDS32922.1
    UniProtKB/Swiss-Prot
    A6NC41, O60499, Q6IAP4, Q96AE8
    UniProtKB/TrEMBL
    K7EIY4
    Related
    ENSP00000466298.1, ENST00000587230.6
    Conserved Domains (2) summary
    cd15851
    Location:160 → 225
    SNARE_Syntaxin6; SNARE motif of syntaxin 6
    pfam09177
    Location:13 → 103
    Syntaxin-6_N; Syntaxin 6, N-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    13144058..13150375 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528397.3 → XP_011526699.1  syntaxin-10 isoform X1

    Conserved Domains (1) summary
    pfam09177
    Location:13 → 103
    Syntaxin-6_N; Syntaxin 6, N-terminal

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    13269272..13275588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322481.1 → XP_054178456.1  syntaxin-10 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O60499.1 GenPept UniProtKB/Swiss-Prot:O60499

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