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FCGBP Fc gamma binding protein [ Homo sapiens (human) ]

Gene ID: 8857, updated on 10-Dec-2024

Summary

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Official Symbol
FCGBPprovided by HGNC
Official Full Name
Fc gamma binding proteinprovided by HGNC
Primary source
HGNC:HGNC:13572
See related
Ensembl:ENSG00000275395 MIM:617553; AllianceGenome:HGNC:13572
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FC(GAMMA)BP
Summary
Located in extracellular exosome. [provided by Alliance of Genome Resources, Dec 2024]
Annotation information
Annotation category: suggests misassembly
Annotation category: partial on reference assembly
Expression
Biased expression in colon (RPKM 352.9), thyroid (RPKM 129.4) and 4 other tissues See more
Orthologs
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Genomic context

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See FCGBP in Genome Data Viewer
Location:
19q13.2
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (39863323..39934634, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (42668261..42770240, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40353963..40440541, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10613 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10614 Neighboring gene dual specificity tyrosine phosphorylation regulated kinase 1B Neighboring gene microRNA 6719 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40335824-40336564 Neighboring gene fibrillarin Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:40357069-40358268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:40376357-40376858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:40433231-40433732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14632 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14633 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:40449389-40449889 Neighboring gene Sharpr-MPRA regulatory region 5808 Neighboring gene proline rich 13 pseudogene 5 Neighboring gene uncharacterized LOC124904722 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:40465439-40466248

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. The GCTM-5 epitope associated with the mucin-like glycoprotein FCGBP marks progenitor cells in tissues of endodermal origin. Stamp LA, et al. Stem Cells, 2012 Sep. PMID 22761039, Free PMC Article
  2. The molecular configuration and ultrastructural locations of an IgG Fc binding site in human colonic epithelium. Kobayashi K, et al. J Immunol, 1991 Jan 1. PMID 1984453
  3. Human IgGFc binding protein (FcgammaBP) in colonic epithelial cells exhibits mucin-like structure. Harada N, et al. J Biol Chem, 1997 Jun 13. PMID 9182547
  4. Detection of Fcgamma binding protein antigen in human sera and its relation with autoimmune diseases. Kobayashi K, et al. Immunol Lett, 2001 Dec 3. PMID 11600203
  5. Differential expression of IgG Fc binding protein (FcgammaBP) in human normal thyroid tissue, thyroid adenomas and thyroid carcinomas. O'Donovan N, et al. J Endocrinol, 2002 Sep. PMID 12208673

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Non-coding RNA-related FCGBP downregulation in head and neck squamous cell carcinoma: a novel biomarker for predicting paclitaxel resistance and immunosuppressive microenvironment.
    Title: Non-coding RNA-related FCGBP downregulation in head and neck squamous cell carcinoma: a novel biomarker for predicting paclitaxel resistance and immunosuppressive microenvironment.
  2. Revealing the role of necroptosis microenvironment: FCGBP + tumor-associated macrophages drive primary liver cancer differentiation towards cHCC-CCA or iCCA.
    Title: Revealing the role of necroptosis microenvironment: FCGBP + tumor-associated macrophages drive primary liver cancer differentiation towards cHCC-CCA or iCCA.
  3. [IgG Fc binding protein (FCGBP) as a prognostic marker of low-grade glioma and its correlation analysis with immune infiltration].
    Title: [IgG Fc binding protein (FCGBP) as a prognostic marker of low-grade glioma and its correlation analysis with immune infiltration].
  4. Fc fragment of IgG binding protein is correlated with immune infiltration levels in hepatocellular carcinoma.
    Title: Fc fragment of IgG binding protein is correlated with immune infiltration levels in hepatocellular carcinoma.
  5. Role of the mucin-like glycoprotein FCGBP in mucosal immunity and cancer.
    Title: Role of the mucin-like glycoprotein FCGBP in mucosal immunity and cancer.
  6. FCGBP Is a Promising Prognostic Biomarker and Correlates with Immunotherapy Efficacy in Oral Squamous Cell Carcinoma.
    Title: FCGBP Is a Promising Prognostic Biomarker and Correlates with Immunotherapy Efficacy in Oral Squamous Cell Carcinoma.
  7. FcGBP and VCAM-1 are ponderable biomarkers for differential diagnosis of alcoholic liver cirrhosis.
    Title: FcGBP and VCAM-1 are ponderable biomarkers for differential diagnosis of alcoholic liver cirrhosis.
  8. IgGFc-binding protein in pregnancies complicated by spontaneous preterm delivery: a retrospective cohort study.
    Title: IgGFc-binding protein in pregnancies complicated by spontaneous preterm delivery: a retrospective cohort study.
  9. The IgGFc-binding protein FCGBP is secreted with all GDPH sequences cleaved but maintained by interfragment disulfide bonds.
    Title: The IgGFc-binding protein FCGBP is secreted with all GDPH sequences cleaved but maintained by interfragment disulfide bonds.
  10. A bioinformatic analysis: the overexpression and clinical significance of FCGBP in ovarian cancer.
    Title: A bioinformatic analysis: the overexpression and clinical significance of FCGBP in ovarian cancer.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
IgGFc-binding protein
Names
Fc fragment of IgG binding protein
Human Fc gamma BP
IgG Fc binding protein
fcgamma-binding protein antigen
fcgammaBP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003890.3 → NP_003881.2  IgGFc-binding protein precursor

    See identical proteins and their annotated locations for NP_003881.2

    Status: VALIDATED

    Source sequence(s)
    AC006950, AC007842, AC011536
    UniProtKB/Swiss-Prot
    O95784, Q9Y6R7
    Related
    ENSP00000481056.3, ENST00000616721.6
    Conserved Domains (5) summary
    smart00832
    Location:667 → 742
    C8; This domain contains 8 conserved cysteine residues
    pfam00094
    Location:472 → 627
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:2337 → 2390
    TIL; Trypsin Inhibitor like cysteine rich domain
    cl02516
    Location:5235 → 5382
    VWD; von Willebrand factor type D domain
    cl17735
    Location:1194 → 1245
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    39863323..39934634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646206.1 Reference GRCh38.p14 PATCHES

    Range
    123199..225173 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331644.1 → XP_054187619.1  IgGFc-binding protein isoform X1

    UniProtKB/Swiss-Prot
    O95784, Q9Y6R7

  2. XM_054331643.1 → XP_054187618.1  IgGFc-binding protein isoform X1

    UniProtKB/Swiss-Prot
    O95784, Q9Y6R7

  3. XM_054331645.1 → XP_054187620.1  IgGFc-binding protein isoform X2

    UniProtKB/TrEMBL
    A0A087WXI2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    42668261..42770240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322489.1 → XP_054178464.1  IgGFc-binding protein isoform X1

  2. XM_054322488.1 → XP_054178463.1  IgGFc-binding protein isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y6R7.3 GenPept UniProtKB/Swiss-Prot:Q9Y6R7

Gene LinkOut

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