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HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 [ Homo sapiens (human) ]

Gene ID: 8924, updated on 10-Dec-2024

Summary

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Official Symbol
HERC2provided by HGNC
Official Full Name
HECT and RLD domain containing E3 ubiquitin protein ligase 2provided by HGNC
Primary source
HGNC:HGNC:4868
See related
Ensembl:ENSG00000128731 MIM:605837; AllianceGenome:HGNC:4868
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
jdf2; p528; MRT38; SHEP1; D15F37S1
Summary
This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012]
Expression
Ubiquitous expression in brain (RPKM 8.9), ovary (RPKM 8.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See HERC2 in Genome Data Viewer
Location:
15q13.1
Exon count:
98
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (28111040..28322179, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (25853561..26064943, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (28356186..28567325, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor subunit gamma3 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:27585914-27587113 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:27603646-27604146 Neighboring gene serpin family E member 4, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:27657550-27658104 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:27699000-27700199 Neighboring gene Sharpr-MPRA regulatory region 4259 Neighboring gene NANOG hESC enhancer GRCh37_chr15:27757723-27758304 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:27833083-27833211 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:27883709-27884453 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:27890620-27891400 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:27931705-27932684 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:27939287-27940486 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:27947009-27947605 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:27958849-27960048 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:27996457-27996958 Neighboring gene OCA2 melanosomal transmembrane protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:28115926-28116426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:28142467-28142967 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:28149284-28149784 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_39258 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_39278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:28228378-28228878 Neighboring gene ribosomal protein L5 pseudogene 32 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:28264414-28265082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:28268807-28269306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:28343756-28344408 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:28352349-28352910 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:28352911-28353471 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:28359141-28359640 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 15:28365618 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:28377589-28378366 Neighboring gene MPRA-validated peak2277 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:28526505-28527006 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:28537256-28537799 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:28563777-28564427 Neighboring gene pectinesterase inhibitor 10-like Neighboring gene ribosomal protein L41 pseudogene 2 Neighboring gene HERC2 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression. Eiberg H, et al. Hum Genet, 2008 Mar. PMID 18172690
  2. Novel loss-of-function mutation in HERC2 is associated with severe developmental delay and paediatric lethality. Elpidorou M, et al. J Med Genet, 2021 May. PMID 32571899, Free PMC Article
  3. The ZZ domain of HERC2 is a receptor of arginylated substrates. Tencer AH, et al. Sci Rep, 2022 Apr 11. PMID 35411094, Free PMC Article
  4. Prognostic impact of HERC2 protein and pink-eyed dilution protein in uveal melanoma. Kashyap S, et al. Hum Cell, 2020 Oct. PMID 32686068
  5. Resolving the Insertion Sites of Polymorphic Duplications Reveals a HERC2 Haplotype under Selection. Saitou M, et al. Genome Biol Evol, 2019 Jun 1. PMID 31124564, Free PMC Article

See all (188) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mechanism of orphan subunit recognition during assembly quality control.
    Title: Mechanism of orphan subunit recognition during assembly quality control.
  2. EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centriole.
    Title: EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centriole.
  3. HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway.
    Title: HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway.
  4. Common genetic variants associated with melanoma risk or naevus count in patients with wildtype MC1R melanoma.
    Title: Common genetic variants associated with melanoma risk or naevus count in patients with wildtype MC1R melanoma.
  5. HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress.
    Title: HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress.
  6. Genetic diagnosis in Sudanese and Tunisian families with syndromic intellectual disability through exome sequencing.
    Title: Genetic diagnosis in Sudanese and Tunisian families with syndromic intellectual disability through exome sequencing.
  7. Delineating the expanding phenotype of HERC2-related disorders: The impact of biallelic loss of function versus missense variation.
    Title: Delineating the expanding phenotype of HERC2-related disorders: The impact of biallelic loss of function versus missense variation.
  8. The ZZ domain of HERC2 is a receptor of arginylated substrates.
    Title: The ZZ domain of HERC2 is a receptor of arginylated substrates.
  9. Further insight into the global variability of the OCA2-HERC2 locus for human pigmentation from multiallelic markers.
    Title: Further insight into the global variability of the OCA2-HERC2 locus for human pigmentation from multiallelic markers.
  10. Blended phenotype of combination of HERC2 and AP3B2 deficiency and Angelman syndrome caused by paternal isodisomy of chromosome 15.
    Title: Blended phenotype of combination of HERC2 and AP3B2 deficiency and Angelman syndrome caused by paternal isodisomy of chromosome 15.
Submit: New GeneRIF Correction See all GeneRIFs (59)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Developmental delay with autism spectrum disorder and gait instability
MedGen: C3809753 OMIM: 615516 GeneReviews: Not available
Compare labs
Prader-Willi syndrome
MedGen: C0032897 OMIM: 176270 GeneReviews: Prader-Willi Syndrome
Compare labs
SKIN/HAIR/EYE PIGMENTATION 1, BLUE/NONBLUE EYES
MedGen: C1856895 OMIM: 227220 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.
EBI GWAS Catalog
Digital quantification of human eye color highlights genetic association of three new loci.
EBI GWAS Catalog
Genetic determinants of hair, eye and skin pigmentation in Europeans.
EBI GWAS Catalog
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.
EBI GWAS Catalog
Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
EBI GWAS Catalog
Genome-wide association studies of quantitatively measured skin, hair, and eye pigmentation in four European populations.
EBI GWAS Catalog
The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.
EBI GWAS Catalog
Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene.
EBI GWAS Catalog
Web-based, participant-driven studies yield novel genetic associations for common traits.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with hect domain and RLD 2 (HERC2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0393, DKFZp547P028

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SUMO binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase HERC2
Names
HECT-type E3 ubiquitin transferase HERC2
hect domain and RCC1-like domain-containing protein 2
hect domain and RLD 2
probable E3 ubiquitin-protein ligase HERC2
NP_004658.3
XP_005268333.1
XP_006720789.1
XP_006720790.1
XP_016878184.1
XP_016878185.1
XP_016878186.1
XP_016878187.1
XP_047289162.1
XP_047289163.1
XP_047289164.1
XP_047289165.1
XP_054187823.1
XP_054187824.1
XP_054187825.1
XP_054187826.1
XP_054187827.1
XP_054187828.1
XP_054187829.1
XP_054187830.1
XP_054187831.1
XP_054187832.1
XP_054187833.1
XP_054235020.1
XP_054235021.1
XP_054235022.1
XP_054235023.1
XP_054235024.1
XP_054235025.1
XP_054235026.1
XP_054235027.1
XP_054235028.1
XP_054235029.1
XP_054235030.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016355.1 RefSeqGene

    Range
    4971..216110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004667.6 → NP_004658.3  E3 ubiquitin-protein ligase HERC2

    See identical proteins and their annotated locations for NP_004658.3

    Status: REVIEWED

    Source sequence(s)
    AC091304, AC126332, AC135329, AF071172, AI820017, AK122977, AU100235, AW897649, BC148318, BX440995, CF135750, CX784863, DA868501
    Consensus CDS
    CCDS10021.1
    UniProtKB/Swiss-Prot
    O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1
    Related
    ENSP00000261609.8, ENST00000261609.13
    Conserved Domains (10) summary
    cd08664
    Location:2765 → 2910
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    smart00119
    Location:4464 → 4790
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:4421 → 4792
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2706 → 2750
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2460 → 2507
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
    pfam00173
    Location:1209 → 1282
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam00415
    Location:675 → 724
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam06701
    Location:1870 → 1929
    MIB_HERC2; Mib_herc2
    pfam11515
    Location:2554 → 2631
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam13540
    Location:4039 → 4069
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    28111040..28322179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720727.4 → XP_006720790.1  E3 ubiquitin-protein ligase HERC2 isoform X4

    See identical proteins and their annotated locations for XP_006720790.1

    Conserved Domains (10) summary
    cd08664
    Location:2679 → 2824
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    smart00119
    Location:4378 → 4704
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:4335 → 4706
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2620 → 2664
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2374 → 2421
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
    pfam00173
    Location:1123 → 1196
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam00415
    Location:589 → 638
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam06701
    Location:1784 → 1843
    MIB_HERC2; Mib_herc2
    pfam11515
    Location:2468 → 2545
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam13540
    Location:3953 → 3983
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat

  2. XM_006720726.4 → XP_006720789.1  E3 ubiquitin-protein ligase HERC2 isoform X1

    See identical proteins and their annotated locations for XP_006720789.1

    Conserved Domains (10) summary
    cd08664
    Location:2760 → 2905
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    smart00119
    Location:4459 → 4785
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:4416 → 4787
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2701 → 2745
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2455 → 2502
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
    pfam00173
    Location:1204 → 1277
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam00415
    Location:675 → 724
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam06701
    Location:1865 → 1924
    MIB_HERC2; Mib_herc2
    pfam11515
    Location:2549 → 2626
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam13540
    Location:4034 → 4064
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat

  3. XM_005268276.6 → XP_005268333.1  E3 ubiquitin-protein ligase HERC2 isoform X3

    See identical proteins and their annotated locations for XP_005268333.1

    Conserved Domains (10) summary
    cd08664
    Location:2727 → 2872
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    smart00119
    Location:4426 → 4752
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:4383 → 4754
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2668 → 2712
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2422 → 2469
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
    pfam00173
    Location:1171 → 1244
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam00415
    Location:637 → 686
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam06701
    Location:1832 → 1891
    MIB_HERC2; Mib_herc2
    pfam11515
    Location:2516 → 2593
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam13540
    Location:4001 → 4031
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat

  4. XM_017022695.1 → XP_016878184.1  E3 ubiquitin-protein ligase HERC2 isoform X3

    Conserved Domains (10) summary
    cd08664
    Location:2727 → 2872
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    smart00119
    Location:4426 → 4752
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:4383 → 4754
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2668 → 2712
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2422 → 2469
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
    pfam00173
    Location:1171 → 1244
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam00415
    Location:637 → 686
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam06701
    Location:1832 → 1891
    MIB_HERC2; Mib_herc2
    pfam11515
    Location:2516 → 2593
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam13540
    Location:4001 → 4031
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat

  5. XM_047433206.1 → XP_047289162.1  E3 ubiquitin-protein ligase HERC2 isoform X2

  6. XM_017022696.2 → XP_016878185.1  E3 ubiquitin-protein ligase HERC2 isoform X3

    Conserved Domains (10) summary
    cd08664
    Location:2727 → 2872
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    smart00119
    Location:4426 → 4752
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:4383 → 4754
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2668 → 2712
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2422 → 2469
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
    pfam00173
    Location:1171 → 1244
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam00415
    Location:637 → 686
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam06701
    Location:1832 → 1891
    MIB_HERC2; Mib_herc2
    pfam11515
    Location:2516 → 2593
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam13540
    Location:4001 → 4031
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat

  7. XM_047433207.1 → XP_047289163.1  E3 ubiquitin-protein ligase HERC2 isoform X5

  8. XM_017022697.2 → XP_016878186.1  E3 ubiquitin-protein ligase HERC2 isoform X8

    UniProtKB/TrEMBL
    A0A0J9YVP0

  9. XM_017022698.2 → XP_016878187.1  E3 ubiquitin-protein ligase HERC2 isoform X8

    UniProtKB/TrEMBL
    A0A0J9YVP0

  10. XM_047433208.1 → XP_047289164.1  E3 ubiquitin-protein ligase HERC2 isoform X6

  11. XM_047433209.1 → XP_047289165.1  E3 ubiquitin-protein ligase HERC2 isoform X7

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_011332701.1 Reference GRCh38.p14 PATCHES

    Range
    244504..455617 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331853.1 → XP_054187828.1  E3 ubiquitin-protein ligase HERC2 isoform X4

  2. XM_054331848.1 → XP_054187823.1  E3 ubiquitin-protein ligase HERC2 isoform X1

  3. XM_054331852.1 → XP_054187827.1  E3 ubiquitin-protein ligase HERC2 isoform X3

  4. XM_054331850.1 → XP_054187825.1  E3 ubiquitin-protein ligase HERC2 isoform X3

  5. XM_054331849.1 → XP_054187824.1  E3 ubiquitin-protein ligase HERC2 isoform X2

  6. XM_054331851.1 → XP_054187826.1  E3 ubiquitin-protein ligase HERC2 isoform X3

  7. XM_054331854.1 → XP_054187829.1  E3 ubiquitin-protein ligase HERC2 isoform X5

  8. XM_054331857.1 → XP_054187832.1  E3 ubiquitin-protein ligase HERC2 isoform X8

    UniProtKB/TrEMBL
    A0A0J9YVP0

  9. XM_054331858.1 → XP_054187833.1  E3 ubiquitin-protein ligase HERC2 isoform X8

    UniProtKB/TrEMBL
    A0A0J9YVP0

  10. XM_054331855.1 → XP_054187830.1  E3 ubiquitin-protein ligase HERC2 isoform X6

  11. XM_054331856.1 → XP_054187831.1  E3 ubiquitin-protein ligase HERC2 isoform X7

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187660.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    244504..569403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    25853561..26064943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379050.1 → XP_054235025.1  E3 ubiquitin-protein ligase HERC2 isoform X4

  2. XM_054379045.1 → XP_054235020.1  E3 ubiquitin-protein ligase HERC2 isoform X1

  3. XM_054379049.1 → XP_054235024.1  E3 ubiquitin-protein ligase HERC2 isoform X3

  4. XM_054379047.1 → XP_054235022.1  E3 ubiquitin-protein ligase HERC2 isoform X3

  5. XM_054379046.1 → XP_054235021.1  E3 ubiquitin-protein ligase HERC2 isoform X2

  6. XM_054379048.1 → XP_054235023.1  E3 ubiquitin-protein ligase HERC2 isoform X3

  7. XM_054379051.1 → XP_054235026.1  E3 ubiquitin-protein ligase HERC2 isoform X5

  8. XM_054379054.1 → XP_054235029.1  E3 ubiquitin-protein ligase HERC2 isoform X8

    UniProtKB/TrEMBL
    A0A0J9YVP0

  9. XM_054379055.1 → XP_054235030.1  E3 ubiquitin-protein ligase HERC2 isoform X8

    UniProtKB/TrEMBL
    A0A0J9YVP0

  10. XM_054379052.1 → XP_054235027.1  E3 ubiquitin-protein ligase HERC2 isoform X6

  11. XM_054379053.1 → XP_054235028.1  E3 ubiquitin-protein ligase HERC2 isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95714.2 GenPept UniProtKB/Swiss-Prot:O95714

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