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TRIM15 tripartite motif containing 15 [ Homo sapiens (human) ]

Gene ID: 89870, updated on 2-Nov-2024

Summary

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Official Symbol
TRIM15provided by HGNC
Official Full Name
tripartite motif containing 15provided by HGNC
Primary source
HGNC:HGNC:16284
See related
Ensembl:ENSG00000204610 AllianceGenome:HGNC:16284
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF93; ZNFB7; ZNF178
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Expression
Biased expression in duodenum (RPKM 12.6), small intestine (RPKM 9.2) and 6 other tissues See more
Orthologs
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Genomic context

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See TRIM15 in Genome Data Viewer
Location:
6p22.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (30163546..30172693)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (30027684..30036952)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30131323..30140470)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene tripartite motif containing 40 Neighboring gene tripartite motif containing 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30139523-30140072 Neighboring gene MPRA-validated peak5749 silencer Neighboring gene PAIP1 pseudogene 1 Neighboring gene tripartite motif containing 26 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:30168993-30169678 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:30169679-30170363 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30175183-30176130 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30181514-30182402 Neighboring gene tripartite motif containing 26B, pseudogene Neighboring gene HLA complex group 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Knockdown of TRIM15 inhibits the proliferation, migration and invasion of esophageal squamous cell carcinoma cells through inactivation of the Wnt/β-catenin signaling pathway. Zhang L, et al. J Bioenerg Biomembr, 2021 Apr. PMID 33515345
  2. TRIM15 Exerts Anti-Tumor Effects Through Suppressing Cancer Cell Invasion in Gastric Adenocarcinoma. Chen W, et al. Med Sci Monit, 2018 Nov 9. PMID 30412518, Free PMC Article
  3. Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection. Goei VL, et al. Am J Hum Genet, 1994 Feb. PMID 8304341, Free PMC Article
  4. TNF-α-induced E3 ligase, TRIM15 inhibits TNF-α-regulated NF-κB pathway by promoting turnover of K63 linked ubiquitination of TAK1. Roy M, et al. Cell Signal, 2022 Mar. PMID 34871740
  5. TRIM15 promotes the invasion and metastasis of pancreatic cancer cells by mediating APOA1 ubiquitination and degradation. Sun Y, et al. Biochim Biophys Acta Mol Basis Dis, 2021 Nov 1. PMID 34311082

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRIM15 forms a regulatory loop with the AKT/FOXO1 axis and LASP1 to modulate the sensitivity of HCC cells to TKIs.
    Title: TRIM15 forms a regulatory loop with the AKT/FOXO1 axis and LASP1 to modulate the sensitivity of HCC cells to TKIs.
  2. E3 ligase TRIM15 facilitates non-small cell lung cancer progression through mediating Keap1-Nrf2 signaling pathway.
    Title: E3 ligase TRIM15 facilitates non-small cell lung cancer progression through mediating Keap1-Nrf2 signaling pathway.
  3. Knockdown of TRIM15 inhibits the proliferation, migration and invasion of esophageal squamous cell carcinoma cells through inactivation of the Wnt/beta-catenin signaling pathway.
    Title: Knockdown of TRIM15 inhibits the proliferation, migration and invasion of esophageal squamous cell carcinoma cells through inactivation of the Wnt/β-catenin signaling pathway.
  4. TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination.
    Title: TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination.
  5. TCGA database showed that higher TRIM15 RNA transcription indicates poorer overall survival of gastric cancer patients. Besides, low expression of TRIM15 was significantly associated with advanced tumor invasion depth and advanced TNM stage.
    Title: TRIM15 Exerts Anti-Tumor Effects Through Suppressing Cancer Cell Invasion in Gastric Adenocarcinoma.
  6. TRIM15-depleted cells display impaired cell migration and reduced focal adhesion disassembly rates.
    Title: TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly.
  7. TRIM15 may function as a tumor suppressor of colon cancer.
    Title: Role of the focal adhesion protein TRIM15 in colon cancer development.
  8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: Refining the association of MHC with multiple sclerosis in African Americans.
  10. Downregulation of TRIM11 and TRIM15 enhanced virus release suggesting that these proteins contribute to the endogenous restriction of retroviruses in cells.
    Title: TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of proneness to anger.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Fluorescence microscope analysis demonstrates a reduction of HIV-1 Gag fluorescence at the plasma membrane in cells containing cytoplasmic TRIM15 bodies PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular sequestering activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mesodermal cell fate determination TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of intracellular transport of viral material IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of non-canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of RIG-I signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of type I interferon production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in suppression of viral release by host IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in suppression of viral release by host IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase TRIM15
Names
RING finger protein 93
tripartite motif-containing protein 15
zinc finger protein 178
zinc finger protein B7
NP_150232.2
XP_011513289.1
XP_011513290.1
XP_047275459.1
XP_054184499.1
XP_054184500.1
XP_054184501.1
XP_054185901.1
XP_054185902.1
XP_054185903.1
XP_054186394.1
XP_054186395.1
XP_054186396.1
XP_054186667.1
XP_054186668.1
XP_054186669.1
XP_054186887.1
XP_054186888.1
XP_054186889.1
XP_054187166.1
XP_054187167.1
XP_054187168.1
XP_054187408.1
XP_054187409.1
XP_054187410.1
XP_054212687.1
XP_054212688.1
XP_054212689.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033229.3 → NP_150232.2  E3 ubiquitin-protein ligase TRIM15

    See identical proteins and their annotated locations for NP_150232.2

    Status: REVIEWED

    Source sequence(s)
    AI739162, AL669914, BC038585, BP270476, U34249
    Consensus CDS
    CCDS4677.1
    UniProtKB/Swiss-Prot
    A2BEC9, O95604, Q8IUX9, Q9C018, Q9C019
    UniProtKB/TrEMBL
    A0A0G2JJP1, A0A1U9X8P2, A6NEF7, A8K2L5, Q0EFD1, Q5SRL0
    Related
    ENSP00000365884.4, ENST00000376694.9
    Conserved Domains (5) summary
    smart00336
    Location:80 → 119
    BBOX; B-Box-type zinc finger
    pfam09088
    Location:252 → 327
    MIF4G_like; MIF4G like
    cd15826
    Location:295 → 464
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cd16543
    Location:16 → 61
    RING-HC_RNF135_like; RING finger, HC subclass, found in RING finger protein 135 (RNF135), tripartite motif-containing protein 15 (TRIM15) and similar proteins
    cl25732
    Location:121 → 241
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    30163546..30172693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514987.2 → XP_011513289.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

    Conserved Domains (2) summary
    pfam09088
    Location:147 → 222
    MIF4G_like; MIF4G like
    cd15826
    Location:190 → 359
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)

  2. XM_047419503.1 → XP_047275459.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

  3. XM_011514988.3 → XP_011513290.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

    See identical proteins and their annotated locations for XP_011513290.1

    Conserved Domains (2) summary
    pfam09088
    Location:45 → 120
    MIF4G_like; MIF4G like
    cd15826
    Location:88 → 257
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    1421505..1430773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328524.1 → XP_054184499.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

  2. XM_054328526.1 → XP_054184501.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

  3. XM_054328525.1 → XP_054184500.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    1643223..1652491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329926.1 → XP_054185901.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

  2. XM_054329928.1 → XP_054185903.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

  3. XM_054329927.1 → XP_054185902.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    1419326..1428594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330419.1 → XP_054186394.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

  2. XM_054330421.1 → XP_054186396.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

  3. XM_054330420.1 → XP_054186395.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

    Range
    1474127..1483395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330692.1 → XP_054186667.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

  2. XM_054330694.1 → XP_054186669.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

  3. XM_054330693.1 → XP_054186668.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    1507498..1516766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330912.1 → XP_054186887.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

  2. XM_054330914.1 → XP_054186889.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

  3. XM_054330913.1 → XP_054186888.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    1418553..1427821
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331191.1 → XP_054187166.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

  2. XM_054331193.1 → XP_054187168.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

  3. XM_054331192.1 → XP_054187167.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    1462356..1471624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331433.1 → XP_054187408.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

  2. XM_054331435.1 → XP_054187410.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

  3. XM_054331434.1 → XP_054187409.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    30027684..30036952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356712.1 → XP_054212687.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

  2. XM_054356714.1 → XP_054212689.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

  3. XM_054356713.1 → XP_054212688.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_052812.1: Suppressed sequence

    Description
    NM_052812.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C019.1 GenPept UniProtKB/Swiss-Prot:Q9C019

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