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ZSWIM1 zinc finger SWIM-type containing 1 [ Homo sapiens (human) ]

Gene ID: 90204, updated on 10-Dec-2024

Summary

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Official Symbol
ZSWIM1provided by HGNC
Official Full Name
zinc finger SWIM-type containing 1provided by HGNC
Primary source
HGNC:HGNC:16155
See related
Ensembl:ENSG00000168612 AllianceGenome:HGNC:16155
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C20orf162
Summary
Predicted to enable zinc ion binding activity. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in ovary (RPKM 3.0), testis (RPKM 2.7) and 25 other tissues See more
Orthologs
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Genomic context

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See ZSWIM1 in Genome Data Viewer
Location:
20q13.12
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (45880920..45885266)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (47617414..47621760)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44509866..44513905)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene sorting nexin family member 21 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:44470503-44471055 Neighboring gene acyl-CoA thioesterase 8 Neighboring gene MPRA-validated peak4224 silencer Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:44482305-44482834 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:44482835-44483364 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:44483365-44483894 Neighboring gene zinc finger SWIM-type containing 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17953 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:44514972-44515472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:44515473-44515973 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:44519312-44520021 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17954 Neighboring gene spermatogenesis associated 25 Neighboring gene neuralized E3 ubiquitin protein ligase 2 Neighboring gene cathepsin A Neighboring gene phospholipid transfer protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. ZSWIM1 Promotes the Proliferation and Metastasis of Lung Adenocarcinoma Cells through the STK38/MEKK2/ERK1/2 Axis. Gao X, et al. J Proteome Res, 2023 Apr 7. PMID 36511424
  2. ZSWIM1: a novel biomarker in T helper cell differentiation. Ko KK, et al. Immunol Lett, 2014 Aug. PMID 24508175
  3. [TRIM21 Inhibits the Proliferation and Migration of Lung Adenocarcinoma Cells 
by Interacting with ZSWIM1]. Chen L, et al. Zhongguo Fei Ai Za Zhi, 2024 May 20. PMID 38880921, Free PMC Article
  4. The DNA sequence and comparative analysis of human chromosome 20. Deloukas P, et al. Nature, 2001 Dec 20-27. PMID 11780052
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Fei T, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28611215, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [TRIM21 Inhibits the Proliferation and Migration of Lung Adenocarcinoma Cells by Interacting with ZSWIM1].
    Title: [TRIM21 Inhibits the Proliferation and Migration of Lung Adenocarcinoma Cells 
by Interacting with ZSWIM1].
  2. ZSWIM1 Promotes the Proliferation and Metastasis of Lung Adenocarcinoma Cells through the STK38/MEKK2/ERK1/2 Axis.
    Title: ZSWIM1 Promotes the Proliferation and Metastasis of Lung Adenocarcinoma Cells through the STK38/MEKK2/ERK1/2 Axis.
  3. The activation sensitive nature of ZSWIM1 expression suggests that it may play a novel role in the development or function of T helper cells.
    Title: ZSWIM1: a novel biomarker in T helper cell differentiation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger SWIM domain-containing protein 1
Names
zinc finger, SWIM domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080603.5 → NP_542170.3  zinc finger SWIM domain-containing protein 1

    See identical proteins and their annotated locations for NP_542170.3

    Status: VALIDATED

    Source sequence(s)
    AL008726
    Consensus CDS
    CCDS13382.2
    UniProtKB/Swiss-Prot
    Q5JZH2, Q9BR11, Q9BR12, Q9BV30
    UniProtKB/TrEMBL
    A8K5I9
    Related
    ENSP00000361601.1, ENST00000372523.1
    Conserved Domains (1) summary
    pfam04434
    Location:379 → 404
    SWIM; SWIM zinc finger

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    45880920..45885266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260611.5 → XP_005260668.1  zinc finger SWIM domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005260668.1

    UniProtKB/Swiss-Prot
    Q5JZH2, Q9BR11, Q9BR12, Q9BV30
    UniProtKB/TrEMBL
    A8K5I9
    Conserved Domains (1) summary
    pfam04434
    Location:379 → 404
    SWIM; SWIM zinc finger

  2. XM_005260610.6 → XP_005260667.1  zinc finger SWIM domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005260667.1

    UniProtKB/Swiss-Prot
    Q5JZH2, Q9BR11, Q9BR12, Q9BV30
    UniProtKB/TrEMBL
    A8K5I9
    Conserved Domains (1) summary
    pfam04434
    Location:379 → 404
    SWIM; SWIM zinc finger

  3. XM_011529100.3 → XP_011527402.1  zinc finger SWIM domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011527402.1

    UniProtKB/Swiss-Prot
    Q5JZH2, Q9BR11, Q9BR12, Q9BV30
    UniProtKB/TrEMBL
    A8K5I9
    Conserved Domains (1) summary
    pfam04434
    Location:379 → 404
    SWIM; SWIM zinc finger

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    47617414..47621760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324203.1 → XP_054180178.1  zinc finger SWIM domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5JZH2, Q9BR11, Q9BR12, Q9BV30
    UniProtKB/TrEMBL
    A8K5I9

  2. XM_054324204.1 → XP_054180179.1  zinc finger SWIM domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5JZH2, Q9BR11, Q9BR12, Q9BV30
    UniProtKB/TrEMBL
    A8K5I9

  3. XM_054324205.1 → XP_054180180.1  zinc finger SWIM domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5JZH2, Q9BR11, Q9BR12, Q9BV30
    UniProtKB/TrEMBL
    A8K5I9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BR11.2 GenPept UniProtKB/Swiss-Prot:Q9BR11

Gene LinkOut

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