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EIF1AY eukaryotic translation initiation factor 1A Y-linked [ Homo sapiens (human) ]

Gene ID: 9086, updated on 10-Dec-2024

Summary

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Official Symbol
EIF1AYprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 1A Y-linkedprovided by HGNC
Primary source
HGNC:HGNC:3252
See related
Ensembl:ENSG00000198692 MIM:400014; AllianceGenome:HGNC:3252
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
eIF-4C
Summary
This gene is located on the non-recombining region of the Y chromosome. It encodes a protein related to eukaryotic translation initiation factor 1A (EIF1A), which may function in stabilizing the binding of the initiator Met-tRNA to 40S ribosomal subunits. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Broad expression in bone marrow (RPKM 13.9), prostate (RPKM 13.1) and 20 other tissues See more
Orthologs
all
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Genomic context

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See EIF1AY in Genome Data Viewer
Location:
Yq11.223
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (20575776..20593154)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (21450981..21468360)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (22737662..22755040)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene testis expressed transcript, Y-linked 10 Neighboring gene lysine demethylase 5D pseudogene 1 Neighboring gene family with sequence similarity 8, member A1 pseudogene Neighboring gene transducin beta like 1 Y-linked pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Y chromosome gene expression in the blood of male patients with ischemic stroke compared with male controls. Tian Y, et al. Gend Med, 2012 Apr. PMID 22365286, Free PMC Article
  2. H-Y antibody titers are increased in unexplained secondary recurrent miscarriage patients and associated with low male : female ratio in subsequent live births. Nielsen HS, et al. Hum Reprod, 2010 Nov. PMID 20823116, Free PMC Article
  3. The gene expression profile of patients with new-onset heart failure reveals important gender-specific differences. Heidecker B, et al. Eur Heart J, 2010 May. PMID 20031959, Free PMC Article
  4. Expression profile of AZF genes in testicular biopsies of azoospermic men. Kleiman SE, et al. Hum Reprod, 2007 Jan. PMID 16936303
  5. Expression and significance of Rap1A in testes of azoospermic subjects. Yang B, et al. Asian J Androl, 2004 Mar. PMID 15064832

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The N-terminal tail of eIF1A mediates the interaction with eIF5 and eIF1.
    Title: The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes.
  2. investigated 12 single-nucleotide polymorphisms in Y-linked neuroligin 4, transducin b-like 1, and eukaryotic translation initiation factor 1a genes, results suggest a Y chromosome effect in autism
    Title: Association of Y chromosome haplotypes with autism.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association of Y chromosome haplotypes with autism.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ45762

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 1A, Y-chromosomal
Names
eIF1A Y isoform
eukaryotic translation initiation factor 1A, Y chromosome
eukaryotic translation initiation factor 4C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278612.2 → NP_001265541.1  eukaryotic translation initiation factor 1A, Y-chromosomal isoform 2

    See identical proteins and their annotated locations for NP_001265541.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC007678, AF000987, BG499107, DQ786267
    Consensus CDS
    CCDS65368.1
    UniProtKB/TrEMBL
    A6NJH9
    Related
    ENSP00000372222.3, ENST00000382772.3
    Conserved Domains (1) summary
    cl09927
    Location:1 → 114
    S1_like; Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. Both domains ...

  2. NM_004681.4 → NP_004672.2  eukaryotic translation initiation factor 1A, Y-chromosomal isoform 1

    See identical proteins and their annotated locations for NP_004672.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007678, AF000987, BC005248, BG499107
    Consensus CDS
    CCDS14795.1
    UniProtKB/Swiss-Prot
    O14602, Q9BS77
    Related
    ENSP00000354722.2, ENST00000361365.7
    Conserved Domains (1) summary
    PTZ00329
    Location:1 → 131
    PTZ00329; eukaryotic translation initiation factor 1A; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

    Range
    20575776..20593154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060948.1 Alternate T2T-CHM13v2.0

    Range
    21450981..21468360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14602.4 GenPept UniProtKB/Swiss-Prot:O14602

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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