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VP24 membrane-associated protein [ Zaire ebolavirus ]

Gene ID: 911828, updated on 18-Aug-2023

Summary

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Gene symbol
VP24
Gene description
membrane-associated protein
Locus tag
ZEBOVgp6
Gene type
protein coding
RNA name
VP24
RefSeq status
PROVISIONAL
Organism
Zaire ebolavirus (isolate: Ebola virus/H.sapiens-tc/COD/1976/Yambuku-Mayinga)
Lineage
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Mononegavirales; Filoviridae; Ebolavirus
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Genomic context

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Sequence:
NC_002549.1 (9885..11518)

NC_002549.1Genomic Context describing neighboring genes Neighboring gene polymerase complex protein Neighboring gene matrix protein Neighboring gene second secreted glycoprotein;small secreted glycoprotein;spike glycoprotein Neighboring gene minor nucleoprotein Neighboring gene RNA-dependent RNA polymerase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002549.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of the Ebola Virus VP24 Protein Compromises the Integrity of the Nuclear Envelope and Induces a Laminopathy-Like Cellular Phenotype. Vidal S, et al. mBio, 2021 Aug 31. PMID 34225493, Free PMC Article
  2. The Minor Matrix Protein VP24 from Ebola Virus Lacks Direct Lipid-Binding Properties. Su Y, et al. Viruses, 2020 Aug 8. PMID 32784484, Free PMC Article
  3. Infection of naive target cells with virus-like particles: implications for the function of ebola virus VP24. Hoenen T, et al. J Virol, 2006 Jul. PMID 16809331, Free PMC Article
  4. Production of novel ebola virus-like particles from cDNAs: an alternative to ebola virus generation by reverse genetics. Watanabe S, et al. J Virol, 2004 Jan. PMID 14694131, Free PMC Article
  5. The Ebola Virus Interferon Antagonist VP24 Undergoes Active Nucleocytoplasmic Trafficking. Harrison AR, et al. Viruses, 2021 Aug 19. PMID 34452514, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Ebola Virus Interferon Antagonist VP24 Undergoes Active Nucleocytoplasmic Trafficking.
    Title: The Ebola Virus Interferon Antagonist VP24 Undergoes Active Nucleocytoplasmic Trafficking.
  2. Expression of the Ebola Virus VP24 Protein Compromises the Integrity of the Nuclear Envelope and Induces a Laminopathy-Like Cellular Phenotype.
    Title: Expression of the Ebola Virus VP24 Protein Compromises the Integrity of the Nuclear Envelope and Induces a Laminopathy-Like Cellular Phenotype.
  3. The Minor Matrix Protein VP24 from Ebola Virus Lacks Direct Lipid-Binding Properties.
    Title: The Minor Matrix Protein VP24 from Ebola Virus Lacks Direct Lipid-Binding Properties.
  4. The results indicate that SUMO interacts with VP24 and promotes its USP7-mediated deubiquitination, playing a key role in the interference with the innate immune response mediated by the viral protein.
    Title: Regulation of the Ebola Virus VP24 Protein by SUMO.
  5. We have therefore modeled the structure of the complex of the whole Oct4 POU domain and importin alpha2 using protein-protein docking and molecular dynamics. The model explains how the Ebola virus VP24 protein has a negative effect on the nuclear import of STAT1 by importin alpha but not on Oct4, and how Nup 50 facilitates cargo release from importin alpha
    Title: Structural and mechanistic insights into nuclear transport and delivery of the critical pluripotency factor Oct4 to DNA.
  6. Novel molecular detail on the interaction of Reston virus VP24 and Ebola virus VP24 with human KPNA5 are provided
    Title: Investigating Ebola virus pathogenicity using molecular dynamics.
  7. VP24 protein plays a critical role in the evasion of the host immune response by interacting with human ATP1a1 protein.
    Title: Elucidation of the Ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host-cell protein function.
  8. The VP24 induces host gene expression at 8 h but blocks it at 24 h.
    Title: Different Temporal Effects of Ebola Virus VP35 and VP24 Proteins on Global Gene Expression in Human Dendritic Cells.
  9. eVP24 recognizes a unique nonclassical nuclear localization signal binding site on KPNA5 that is necessary for efficient phosphoryated STAT1 nuclear transport.
    Title: Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1.
  10. VP24 directly binds STAT1 and has a novel, pyramidal fold.
    Title: The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold.
Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Homology

Miscellaneous features

  • Loc: 11497-11500 intergenic region

regulatory

  • Loc: 11485-11496 regulatory_class = polyA_signal_sequence
  • Loc: 11501-11512 regulatory_class = other
  • Loc: 11508-11518 regulatory_class = polyA_signal_sequence
  • Loc: 9885-9896 regulatory_class = other

General protein information

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Preferred Names
membrane-associated protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002549.1 Reference assembly

    Range
    9885..11518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_066250.1 membrane-associated protein [Zaire ebolavirus]

    See identical proteins and their annotated locations for NP_066250.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O11459, Q05322, Q6YNP9, Q773N1, Q8JS60, Q9DQD2
    UniProtKB/TrEMBL
    A0A089WWJ4, A0A0E3NAF3, A0A1C4HD41, A0A1L7B891, L7QHW5, L7QI07
    Conserved Domains (1) summary
    pfam06389
    Location:16 → 231
    Filo_VP24; Filovirus membrane-associated protein VP24
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
AAD14588.1

Gene LinkOut

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Molecular Biology Databases
Research Materials