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NP nucleoprotein [ Zaire ebolavirus ]

Gene ID: 911830, updated on 18-Aug-2023

Summary

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Gene symbol
NP
Gene description
nucleoprotein
Locus tag
ZEBOVgp1
Gene type
protein coding
RNA name
nucleoprotein
RefSeq status
PROVISIONAL
Organism
Zaire ebolavirus (isolate: Ebola virus/H.sapiens-tc/COD/1976/Yambuku-Mayinga)
Lineage
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Mononegavirales; Filoviridae; Ebolavirus
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Genomic context

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Sequence:
NC_002549.1 (56..3026)

NC_002549.1Genomic Context describing neighboring genes Neighboring gene polymerase complex protein Neighboring gene matrix protein Neighboring gene second secreted glycoprotein;small secreted glycoprotein;spike glycoprotein Neighboring gene minor nucleoprotein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002549.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex. Kirchdoerfer RN, et al. Acta Crystallogr F Struct Biol Commun, 2019 May 1. PMID 31045563, Free PMC Article
  2. Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex at 3.6 Å resolution. Sugita Y, et al. Nature, 2018 Nov. PMID 30333622
  3. Characterization of the Ebola virus nucleoprotein-RNA complex. Noda T, et al. J Gen Virol, 2010 Jun. PMID 20164259, Free PMC Article
  4. Analysis of the role of predicted RNA secondary structures in Ebola virus replication. Crary SM, et al. Virology, 2003 Feb 15. PMID 12642094
  5. Analysis of linear B-cell epitopes of the nucleoprotein of ebola virus that distinguish ebola virus subtypes. Niikura M, et al. Clin Diagn Lab Immunol, 2003 Jan. PMID 12522044, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results revealed that SMYD3 was a novel host factor recruited by NP to supporting Ebola virus mRNA transcription through increasing the binding of VP30 to NP.
    Title: Host factor SMYD3 is recruited by Ebola virus nucleoprotein to facilitate viral mRNA transcription.
  2. Molecular structure of the Ebola virus nucleoprotein-RNA complex has been reported.
    Title: Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex.
  3. Data show that the recombinant Ebolavirus nucleoprotein (NP) and the viral matrix protein VP40, which binds with NP, were acetylated by human histone acetyltransferases.
    Title: Acetylation of lysine residues in the recombinant nucleoprotein and VP40 matrix protein of Zaire Ebolavirus by eukaryotic histone acetyltransferases.
  4. structure of a recombinant Ebola virus nucleoprotein-RNA complex expressed in mammalian cells without chemical fixation, at near-atomic resolution using single-particle cryo-electron microscopy
    Title: Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex at 3.6 Å resolution.
  5. Comparison of the percentage of disorder (PID) in nucleocapsid proteins VP30 and NP reveals high correlation between nucleocapsid PIDs and the case-fatality rates of Ebola virus .
    Title: Detection of links between Ebola nucleocapsid and virulence using disorder analysis.
  6. The authors found that the recombinant NP helix is associated with non-viral RNA, which is not protected from RNase digestion and that the morphology of the helix changes depending on the environmental salt concentration.
    Title: Characterization of the Ebola virus nucleoprotein-RNA complex.
  7. enhance our understanding of Ebola virus assembly and in so doing move us closer to the identification of targets for the development of antiviral compounds to combat Ebola virus infection
    Title: Mapping of the VP40-binding regions of the nucleoprotein of Ebola virus.
Submit: New GeneRIF Correction

General gene information

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Homology

regulatory

  • Loc: 3015-3026 regulatory_class = polyA_signal_sequence
  • Loc: 56-67 regulatory_class = other

General protein information

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Preferred Names
nucleoprotein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002549.1 Reference assembly

    Range
    56..3026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_066243.1 nucleoprotein [Zaire ebolavirus]

    See identical proteins and their annotated locations for NP_066243.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P18272, Q773N6, Q8JS64, Q9DQD3, Q9YMG4
    UniProtKB/TrEMBL
    A0A0E3KX27, A0A1L7B882, L7QHU5
    Conserved Domains (1) summary
    pfam05505
    Location:19 → 734
    Ebola_NP; Ebola nucleoprotein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
AAD14590.1

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