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SLC16A4 solute carrier family 16 member 4 [ Homo sapiens (human) ]

Gene ID: 9122, updated on 10-Dec-2024

Summary

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Official Symbol
SLC16A4provided by HGNC
Official Full Name
solute carrier family 16 member 4provided by HGNC
Primary source
HGNC:HGNC:10925
See related
Ensembl:ENSG00000168679 MIM:603878; AllianceGenome:HGNC:10925
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCT4; MCT5
Summary
Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in kidney (RPKM 44.3), placenta (RPKM 12.3) and 10 other tissues See more
Orthologs
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Genomic context

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See SLC16A4 in Genome Data Viewer
Location:
1p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (110362857..110391026, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (110377933..110406181, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110905479..110933648, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RBM15 antisense RNA 1 Neighboring gene uncharacterized LOC124904276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1467 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1468 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:110882428-110883166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:110883828-110884393 Neighboring gene RNA binding motif protein 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1471 Neighboring gene LAMTOR5 and SLC16A4 antisense RNA 1 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1174 Neighboring gene prokineticin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Involvement of Histidine Residue His382 in pH Regulation of MCT4 Activity. Sasaki S, et al. PLoS One, 2014. PMID 25919709, Free PMC Article
  2. Inhibition of monocarboxylate transporter-4 depletes stem-like glioblastoma cells and inhibits HIF transcriptional response in a lactate-independent manner. Lim KS, et al. Oncogene, 2014 Aug 28. PMID 24077291, Free PMC Article
  3. Aberrant expression of monocarboxylate transporter 4 in tumour cells predicts an unfavourable outcome in patients with hepatocellular carcinoma. Ohno A, et al. Liver Int, 2014 Jul. PMID 24433439
  4. Expression of monocarboxylate transporter 4 in human platelets, leukocytes, and tissues assessed by antibodies raised against terminal versus pre-terminal peptides. Merezhinskaya N, et al. Mol Genet Metab, 2006 Feb. PMID 16403666
  5. Benign albeit glycolytic: MCT4 expression and lactate release in giant cell tumour of bone. Avnet S, et al. Bone, 2020 May. PMID 32112988

See all (123) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation.
    Title: Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation.
  2. MCT4 and CD147 colocalize with MMP14 in invadopodia and support matrix degradation and invasion by breast cancer cells.
    Title: MCT4 and CD147 colocalize with MMP14 in invadopodia and support matrix degradation and invasion by breast cancer cells.
  3. SYVN1-mediated ubiquitylation directs localization of MCT4 in the plasma membrane to promote the progression of lung adenocarcinoma.
    Title: SYVN1-mediated ubiquitylation directs localization of MCT4 in the plasma membrane to promote the progression of lung adenocarcinoma.
  4. Immunohistochemical evaluation and prognostic value of monocarboxylate transporter 1 (MCT1) and 4 (MCT4) in T-cell non-Hodgkin lymphoma.
    Title: Immunohistochemical evaluation and prognostic value of monocarboxylate transporter 1 (MCT1) and 4 (MCT4) in T-cell non-Hodgkin lymphoma.
  5. Maternal obesity-associated disruption of polarized lactate transporter MCT4 expression in human placenta.
    Title: Maternal obesity-associated disruption of polarized lactate transporter MCT4 expression in human placenta.
  6. GLUT1, LDHA, and MCT4 Expression Is Deregulated in Cervical Cancer and Precursor Lesions.
    Title: GLUT1, LDHA, and MCT4 Expression Is Deregulated in Cervical Cancer and Precursor Lesions.
  7. TGF-beta1 induced autophagy in cancer associated fibroblasts during hypoxia contributes EMT and glycolysis via MCT4 upregulation.
    Title: TGF-β1 induced autophagy in cancer associated fibroblasts during hypoxia contributes EMT and glycolysis via MCT4 upregulation.
  8. TRIM72 exerts antitumor effects in breast cancer and modulates lactate production and MCT4 promoter activity by interacting with PPP3CA.
    Title: TRIM72 exerts antitumor effects in breast cancer and modulates lactate production and MCT4 promoter activity by interacting with PPP3CA.
  9. Knockdown of Astrocytic Monocarboxylate Transporter 4 in the Motor Cortex Leads to Loss of Dendritic Spines and a Deficit in Motor Learning.
    Title: Knockdown of Astrocytic Monocarboxylate Transporter 4 in the Motor Cortex Leads to Loss of Dendritic Spines and a Deficit in Motor Learning.
  10. ZEB1 induces ROS generation through directly promoting MCT4 transcription to facilitate breast cancer.
    Title: ZEB1 induces ROS generation through directly promoting MCT4 transcription to facilitate breast cancer.
Submit: New GeneRIF Correction See all GeneRIFs (104)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carboxylic acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monocarboxylic acid transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
monocarboxylate transporter 5
Names
MCT 4
MCT 5
monocarboxylate transporter 4
solute carrier family 16 (monocarboxylic acid transporters), member 4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201546.2 → NP_001188475.1  monocarboxylate transporter 5 isoform 2

    See identical proteins and their annotated locations for NP_001188475.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate, in-frame exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to variant 1.
    Source sequence(s)
    AI245349, AK290720, AL833619, BP345760, U59185
    Consensus CDS
    CCDS55623.1
    UniProtKB/TrEMBL
    Q53FH9
    Related
    ENSP00000432495.1, ENST00000472422.6
    Conserved Domains (1) summary
    cl26868
    Location:16 → 426
    2A0111; oxalate/formate antiporter family transporter

  2. NM_001201547.2 → NP_001188476.1  monocarboxylate transporter 5 isoform 3

    See identical proteins and their annotated locations for NP_001188476.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the coding region which results in the use of a downstream start codon initially in a different reading frame, compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct N-terminus yet matches most of the protein when it is compared to isoform 1.
    Source sequence(s)
    AI245349, AK295946, BE893159, U59185
    Consensus CDS
    CCDS55622.1
    UniProtKB/TrEMBL
    Q53FH9
    Related
    ENSP00000446087.1, ENST00000541986.5
    Conserved Domains (1) summary
    cd06174
    Location:8 → 415
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  3. NM_001201548.2 → NP_001188477.1  monocarboxylate transporter 5 isoform 4

    See identical proteins and their annotated locations for NP_001188477.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons in the coding region which results in the use of a downstream start codon initially in a different reading frame, compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct N-terminus yet matches most of the protein when it is compared to isoform 1.
    Source sequence(s)
    AI245349, AK298539, U59185
    Consensus CDS
    CCDS55621.1
    UniProtKB/TrEMBL
    A0A1S5UZI1
    Related
    ENSP00000394790.2, ENST00000437429.6
    Conserved Domains (1) summary
    cl26868
    Location:6 → 335
    2A0111; oxalate/formate antiporter family transporter

  4. NM_001201549.2 → NP_001188478.1  monocarboxylate transporter 5 isoform 5

    See identical proteins and their annotated locations for NP_001188478.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate, in-frame exon in the coding region, compared to variant 1. The resulting protein (isoform 5) is shorter when it is compared to variant 1.
    Source sequence(s)
    AI245349, BC021664, BP345760, U59185
    Consensus CDS
    CCDS55624.1
    UniProtKB/Swiss-Prot
    O15374
    Related
    ENSP00000358796.4, ENST00000369781.8
    Conserved Domains (1) summary
    cl26868
    Location:16 → 306
    2A0111; oxalate/formate antiporter family transporter

  5. NM_001319220.2 → NP_001306149.1  monocarboxylate transporter 5 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two alternate exons compared to variant 1. The resulting isoform (6) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AI245349, AL355488, BX647948
    Conserved Domains (2) summary
    cd06174
    Location:143 → 249
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:12 → 244
    2A0113; monocarboxylate transporter 1

  6. NM_004696.3 → NP_004687.1  monocarboxylate transporter 5 isoform 1

    See identical proteins and their annotated locations for NP_004687.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AI245349, AK313735, U59185
    Consensus CDS
    CCDS823.1
    UniProtKB/Swiss-Prot
    A8K3V5, B2R9C9, B4DJ67, B4DPX7, E7EPY8, G3V175, O15374, Q5T612, Q8WU09
    UniProtKB/TrEMBL
    Q53FH9
    Related
    ENSP00000358794.4, ENST00000369779.9
    Conserved Domains (2) summary
    cd06174
    Location:24 → 477
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:27 → 442
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    110362857..110391026 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711033.4 → XP_006711096.1  monocarboxylate transporter 5 isoform X3

    See identical proteins and their annotated locations for XP_006711096.1

    UniProtKB/TrEMBL
    A0A1S5UZI1
    Conserved Domains (1) summary
    cd06174
    Location:183 → 367
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  2. XM_047433986.1 → XP_047289942.1  monocarboxylate transporter 5 isoform X5

  3. XM_047433990.1 → XP_047289946.1  monocarboxylate transporter 5 isoform X6

  4. XM_047433967.1 → XP_047289923.1  monocarboxylate transporter 5 isoform X2

    UniProtKB/TrEMBL
    Q53FH9

  5. XM_047433980.1 → XP_047289936.1  monocarboxylate transporter 5 isoform X4

  6. XM_005271317.6 → XP_005271374.1  monocarboxylate transporter 5 isoform X1

    See identical proteins and their annotated locations for XP_005271374.1

    UniProtKB/Swiss-Prot
    A8K3V5, B2R9C9, B4DJ67, B4DPX7, E7EPY8, G3V175, O15374, Q5T612, Q8WU09
    UniProtKB/TrEMBL
    Q53FH9
    Conserved Domains (2) summary
    cd06174
    Location:24 → 477
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:27 → 442
    MFS_1; Major Facilitator Superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    110377933..110406181 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339556.1 → XP_054195531.1  monocarboxylate transporter 5 isoform X3

    UniProtKB/TrEMBL
    A0A1S5UZI1

  2. XM_054339558.1 → XP_054195533.1  monocarboxylate transporter 5 isoform X5

  3. XM_054339559.1 → XP_054195534.1  monocarboxylate transporter 5 isoform X6

  4. XM_054339555.1 → XP_054195530.1  monocarboxylate transporter 5 isoform X2

    UniProtKB/TrEMBL
    Q53FH9

  5. XM_054339557.1 → XP_054195532.1  monocarboxylate transporter 5 isoform X4

  6. XM_054339554.1 → XP_054195529.1  monocarboxylate transporter 5 isoform X1

    UniProtKB/Swiss-Prot
    A8K3V5, B2R9C9, B4DJ67, B4DPX7, E7EPY8, G3V175, O15374, Q5T612, Q8WU09
    UniProtKB/TrEMBL
    Q53FH9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15374.1 GenPept UniProtKB/Swiss-Prot:O15374

Gene LinkOut

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