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L RNA-dependent RNA polymerase [ Orthomarburgvirus marburgense ]

Gene ID: 920946, updated on 18-Aug-2023

Summary

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Gene symbol
L
Gene description
RNA-dependent RNA polymerase
Locus tag
MARV_gp7
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Orthomarburgvirus marburgense (isolate: Marburg virus/H.sapiens-tc/KEN/1980/Mt. Elgon-Musoke)
Lineage
Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Filoviridae; Orthomarburgvirus
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Genomic context

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Sequence:
NC_001608.3 (11291..19035)

NC_001608.3Genomic Context describing neighboring genes Neighboring gene glycoprotein Neighboring gene minor nucleoprotein Neighboring gene matrix protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001608.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An active site mutation increases the polymerase activity of the guinea pig-lethal Marburg virus. Koehler A, et al. J Gen Virol, 2016 Oct. PMID 27450090
  2. The nucleotide sequence of the L gene of Marburg virus, a filovirus: homologies with paramyxoviruses and rhabdoviruses. Mühlberger E, et al. Virology, 1992 Apr. PMID 1546452
  3. Homo-oligomerization of Marburgvirus VP35 is essential for its function in replication and transcription. Möller P, et al. J Virol, 2005 Dec. PMID 16282487, Free PMC Article
  4. Interactions of Marburg virus nucleocapsid proteins. Becker S, et al. Virology, 1998 Sep 30. PMID 9791031
  5. Three of the four nucleocapsid proteins of Marburg virus, NP, VP35, and L, are sufficient to mediate replication and transcription of Marburg virus-specific monocistronic minigenomes. Mühlberger E, et al. J Virol, 1998 Nov. PMID 9765419, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The transcription/replication activity of L mutants was strongly enhanced by a substitution at position 741 (S741C).
    Title: An active site mutation increases the polymerase activity of the guinea pig-lethal Marburg virus.
Submit: New GeneRIF Correction

General protein information

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Preferred Names
RNA-dependent RNA polymerase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001608.3 Reference assembly

    Range
    11291..19035
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001531159.1 RNA-dependent RNA polymerase [Orthomarburgvirus marburgense]

    See identical proteins and their annotated locations for YP_001531159.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P31352, Q38L39, Q6T6T7, Q6T6U4
    Conserved Domains (3) summary
    TIGR04198
    Location:1240 → 2319
    paramyx_RNAcap; mRNA capping enzyme, paramyxovirus family
    pfam00946
    Location:9 → 1092
    Mononeg_RNA_pol; Mononegavirales RNA dependent RNA polymerase
    pfam14318
    Location:1108 → 1383
    Mononeg_mRNAcap; Mononegavirales mRNA-capping region V
Protein Accession Links
GenPept Link UniProtKB Link
ABA87130.1

Gene LinkOut

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