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VP40 matrix protein [ Orthomarburgvirus marburgense ]

Gene ID: 920947, updated on 18-Aug-2023

Summary

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Gene symbol
VP40
Gene description
matrix protein
Locus tag
MARV_gp3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Orthomarburgvirus marburgense (isolate: Marburg virus/H.sapiens-tc/KEN/1980/Mt. Elgon-Musoke)
Lineage
Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Filoviridae; Orthomarburgvirus
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Genomic context

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Sequence:
NC_001608.3 (4415..5819)

NC_001608.3Genomic Context describing neighboring genes Neighboring gene nucleoprotein Neighboring gene polymerase complex protein Neighboring gene glycoprotein Neighboring gene minor nucleoprotein Neighboring gene matrix protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001608.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly. Amiar S, et al. J Biol Chem, 2021 Jan-Jun. PMID 34019871, Free PMC Article
  2. Mutation of Hydrophobic Residues in the C-Terminal Domain of the Marburg Virus Matrix Protein VP40 Disrupts Trafficking to the Plasma Membrane. Wijesinghe KJ, et al. Viruses, 2020 Apr 24. PMID 32344654, Free PMC Article
  3. Analysis of the multifunctionality of Marburg virus VP40. Koehler A, et al. J Gen Virol, 2018 Dec. PMID 30394868
  4. Detection of lipid-induced structural changes of the Marburg virus matrix protein VP40 using hydrogen/deuterium exchange-mass spectrometry. Wijesinghe KJ, et al. J Biol Chem, 2017 Apr 14. PMID 28167534, Free PMC Article
  5. Investigation of the Lipid Binding Properties of the Marburg Virus Matrix Protein VP40. Wijesinghe KJ, et al. J Virol, 2015 Dec 30. PMID 26719280, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly.
    Title: Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly.
  2. Ubiquitin Ligase SMURF2 Interacts with Filovirus VP40 and Promotes Egress of VP40 VLPs.
    Title: Ubiquitin Ligase SMURF2 Interacts with Filovirus VP40 and Promotes Egress of VP40 VLPs.
  3. Mutation of Hydrophobic Residues in the C-Terminal Domain of the Marburg Virus Matrix Protein VP40 Disrupts Trafficking to the Plasma Membrane.
    Title: Mutation of Hydrophobic Residues in the C-Terminal Domain of the Marburg Virus Matrix Protein VP40 Disrupts Trafficking to the Plasma Membrane.
  4. Altogether, mutations that interfere with VP40's transition from monomer to higher-order oligomers and/or lipid interactions destroy the protein's multifunctionality.
    Title: Analysis of the multifunctionality of Marburg virus VP40.
  5. a model by which association of the mVP40 dimer with the anionic plasma membrane facilitates assembly of mVP40 oligomers.
    Title: Detection of lipid-induced structural changes of the Marburg virus matrix protein VP40 using hydrogen/deuterium exchange-mass spectrometry.
  6. VP40 associates with anionic lipid membranes in a nonspecific manner that is dependent upon the anionic charge density of the membrane.
    Title: Investigation of the Lipid Binding Properties of the Marburg Virus Matrix Protein VP40.
  7. VP40 forms a dimer in solution, mediated by N-terminal domains, and that formation of this dimer is essential for budding of virus-like particles.
    Title: Crystal Structure of Marburg Virus VP40 Reveals a Broad, Basic Patch for Matrix Assembly and a Requirement of the N-Terminal Domain for Immunosuppression.
  8. This suggests that Ravn virus VP40 acquired, during adaptation to mice, changes in its oligomerization potential that enhanced IFN antagonist function, however, this new capacity impaired VP40 budding from human cells.
    Title: The VP40 protein of Marburg virus exhibits impaired budding and increased sensitivity to human tetherin following mouse adaptation.
  9. In primate cells, the Lake Victoria marburgvirus Musoke strain (MARV) VP40 matrix protein antagonizes alpha/beta interferon (IFN-alpha/beta) and IFN-gamma signaling by inhibiting the activation of the cellular tyrosine kinase Jak1.
    Title: Marburg virus VP40 antagonizes interferon signaling in a species-specific manner.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
matrix protein
YP_001531155.1
  • budding; virus particle formation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001608.3 Reference assembly

    Range
    4415..5819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001531155.1 matrix protein [Orthomarburgvirus marburgense]

    See identical proteins and their annotated locations for YP_001531155.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P35260, Q03040, Q1PD51, Q38L43, Q6T6U1, Q6T6U8
    UniProtKB/TrEMBL
    A0A0E3H7K5, A9Q1H4, E0X113, G9HWE4
    Conserved Domains (1) summary
    pfam07447
    Location:2 → 283
    VP40; Matrix protein VP40
Protein Accession Links
GenPept Link UniProtKB Link
AAR85455.1
ABA87126.1
ADM72997.1
AFV31320.1
AFV31369.1
AGL73410.1
AGL73417.1
QGX74970.1
QGX74977.1
QGX74984.1
QGX74991.1
QIC36347.1

Gene LinkOut

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Molecular Biology Databases
Research Materials