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ZNF670 zinc finger protein 670 [ Homo sapiens (human) ]

Gene ID: 93474, updated on 10-Dec-2024

Summary

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Official Symbol
ZNF670provided by HGNC
Official Full Name
zinc finger protein 670provided by HGNC
Primary source
HGNC:HGNC:28167
See related
Ensembl:ENSG00000277462 AllianceGenome:HGNC:28167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cellular lipid metabolic process. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in testis (RPKM 1.7), endometrium (RPKM 1.3) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF670 in Genome Data Viewer
Location:
1q44
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (247034637..247078811, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (246466233..246510418, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (247197939..247242113, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ZNF670-ZNF695 readthrough (NMD candidate) Neighboring gene zinc finger protein 695 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2865 Neighboring gene Sharpr-MPRA regulatory region 11618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:247165417-247165917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2041 Neighboring gene zinc finger protein 519 pseudogene Neighboring gene DNA primase subunit 1 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr1:247208766-247208933 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:247241976-247242289 Neighboring gene Sharpr-MPRA regulatory region 11854 Neighboring gene zinc finger protein 669 Neighboring gene uncharacterized LOC400812

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. The Foxo1-Inducible Transcriptional Repressor Zfp125 Causes Hepatic Steatosis and Hypercholesterolemia. Fernandes GW, et al. Cell Rep, 2018 Jan 9. PMID 29320745, Free PMC Article
  2. Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study. Niu N, et al. BMC Cancer, 2012 Sep 24. PMID 23006423, Free PMC Article
  3. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
  4. Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance. Pech MF, et al. Elife, 2019 Aug 27. PMID 31452512, Free PMC Article
  5. An empirical framework for binary interactome mapping. Venkatesan K, et al. Nat Methods, 2009 Jan. PMID 19060904, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12606, MGC12466

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 670

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204220.2 → NP_001191149.1  zinc finger protein 670 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    AL512637, DA757117, DB291578, DB367437
    Conserved Domains (5) summary
    smart00349
    Location:4 → 46
    KRAB; krueppel associated box
    COG5048
    Location:222 → 383
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:198 → 218
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:238 → 263
    zf-H2C2_2; Zinc-finger double domain

  2. NM_033213.5 → NP_149990.1  zinc finger protein 670 isoform 1

    See identical proteins and their annotated locations for NP_149990.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL512637, BC005360, DA757117, DB367437
    Consensus CDS
    CCDS31087.1
    UniProtKB/Swiss-Prot
    Q9BS34
    Related
    ENSP00000355459.2, ENST00000366503.3
    Conserved Domains (3) summary
    COG5048
    Location:223 → 384
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:199 → 219
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3 → 44
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    247034637..247078811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    246466233..246510418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BS34.1 GenPept UniProtKB/Swiss-Prot:Q9BS34

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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