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Pcdhb2 protocadherin beta 2 [ Mus musculus (house mouse) ]

Gene ID: 93873, updated on 2-Nov-2024

Summary

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Official Symbol
Pcdhb2provided by MGI
Official Full Name
protocadherin beta 2provided by MGI
Primary source
MGI:MGI:2136735
See related
Ensembl:ENSMUSG00000051599 AllianceGenome:MGI:2136735
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PcdhbB
Summary
Predicted to be involved in cell adhesion. Predicted to be active in plasma membrane. Orthologous to human PCDHB2 (protocadherin beta 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human all
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Genomic context

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See Pcdhb2 in Genome Data Viewer
Location:
18 B3; 18 19.46 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (37427893..37430667)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (37294840..37297614)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene protocadherin alpha 1 Neighboring gene protocadherin alpha 2 Neighboring gene protocadherin alpha 4B Neighboring gene protocadherin alpha 3 Neighboring gene protocadherin alpha 4 Neighboring gene predicted gene, 38666 Neighboring gene protocadherin alpha 5 Neighboring gene predicted gene, 38667 Neighboring gene protocadherin alpha 6 Neighboring gene protocadherin alpha 7 Neighboring gene protocadherin alpha 8 Neighboring gene protocadherin alpha 10 Neighboring gene protocadherin alpha 9 Neighboring gene protocadherin alpha 11 Neighboring gene protocadherin alpha 12 Neighboring gene protocadherin alpha subfamily C, 1 Neighboring gene protocadherin alpha subfamily C, 2 Neighboring gene predicted gene 10544 Neighboring gene STARR-seq mESC enhancer starr_44309 Neighboring gene protocadherin beta 1 Neighboring gene RAD18 homolog pseudogene Neighboring gene protocadherin beta 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Distinct and Cooperative Functions for the Protocadherin-α, -β and -γ Clusters in Neuronal Survival and Axon Targeting. Hasegawa S, et al. Front Mol Neurosci, 2016. PMID 28066179, Free PMC Article
  2. Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice. Xu L, et al. Sci Adv, 2021 Jan. PMID 33523829, Free PMC Article
  3. The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. Vanhalst K, et al. FEBS Lett, 2001 Apr 20. PMID 11322959
  4. CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons. Elbert A, et al. J Neurosci, 2019 Jan 2. PMID 30377227, Free PMC Article
  5. Clustered gamma-protocadherins regulate cortical interneuron programmed cell death. Mancia Leon WR, et al. Elife, 2020 Jul 7. PMID 32633719, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protocadherin beta-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053127.2 → NP_444357.1  protocadherin beta-2

    See identical proteins and their annotated locations for NP_444357.1

    Status: VALIDATED

    Source sequence(s)
    AY013781, BB617745, BC021789
    Consensus CDS
    CCDS29170.1
    UniProtKB/TrEMBL
    B2RUH7, Q91Y00
    Related
    ENSMUSP00000057921.4, ENSMUST00000056522.5
    Conserved Domains (3) summary
    cd11304
    Location:457 → 559
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08266
    Location:33 → 114
    Cadherin_2; Cadherin-like
    pfam16492
    Location:689 → 771
    Cadherin_C_2; Cadherin cytoplasmic C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    37427893..37430667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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