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MED7 mediator complex subunit 7 [ Homo sapiens (human) ]

Gene ID: 9443, updated on 2-Nov-2024

Summary

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Official Symbol
MED7provided by HGNC
Official Full Name
mediator complex subunit 7provided by HGNC
Primary source
HGNC:HGNC:2378
See related
Ensembl:ENSG00000155868 MIM:605045; AllianceGenome:HGNC:2378
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARC34; CRSP9; CRSP33
Summary
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 12.0), thyroid (RPKM 6.9) and 25 other tissues See more
Orthologs
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Genomic context

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See MED7 in Genome Data Viewer
Location:
5q33.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (157137424..157142865, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (157656367..157661808, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (156564435..156569876, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene hepatitis A virus cellular receptor 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:156477155-156477714 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:156499176-156500375 Neighboring gene hepatitis A virus cellular receptor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23498 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23499 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23501 Neighboring gene golgi associated RAB2 interactor family member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16556 Neighboring gene IL2 inducible T cell kinase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23503 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23504 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23505 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23507

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mediator complex (MED) 7: a biomarker associated with good prognosis in invasive breast cancer, especially ER+ luminal subtypes. Joseph C, et al. Br J Cancer, 2018 Apr. PMID 29588513, Free PMC Article
  2. Upregulation of MED7 was associated with progression in hepatocellular carcinoma. Chen ZL, et al. Cancer Biomark, 2023. PMID 38073375
  3. Purification of transcription cofactor complex CRSP. Ryu S, et al. Proc Natl Acad Sci U S A, 1999 Jun 22. PMID 10377381, Free PMC Article
  4. Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein. Boyer TG, et al. Nature, 1999 May 20. PMID 10353252
  5. TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4. Malik S, et al. Mol Cell Biol, 2002 Aug. PMID 12101254, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of MED7 was associated with progression in hepatocellular carcinoma.
    Title: Upregulation of MED7 was associated with progression in hepatocellular carcinoma.
  2. MED7 is an important prognostic marker in Breast cancer, particularly in ER+luminal subtypes, associated with improved survival and warrants future functional analysis.
    Title: Mediator complex (MED) 7: a biomarker associated with good prognosis in invasive breast cancer, especially ER+ luminal subtypes.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of mediator complex subunit 7 (MED7) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
Knockdown of mediator complex subunit 7 (MED7; CRSP9) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed
Knockdown of mediator complex subunit 7 (MED7) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Knockdown of MED7 by siRNAs inhibits HIV LTR-beta-gal activation in the Tat transactivation assay PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: HAVCR2

Homology

Clone Names

  • MGC12284

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity TAS
Traceable Author Statement
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in somatic stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription initiation at RNA polymerase II promoter TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of core mediator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 7
Names
CRSP complex subunit 9
RNA polymerase transcriptional regulation mediator subunit 7 homolog
activator-recruited cofactor 34 kDa component
cofactor required for Sp1 transcriptional activation subunit 9
cofactor required for Sp1 transcriptional activation, subunit 9 (33kD)
cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa
transcriptional coactivator CRSP33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100816.1 → NP_001094286.1  mediator of RNA polymerase II transcription subunit 7

    See identical proteins and their annotated locations for NP_001094286.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AF104251, BQ011916, BQ130907
    Consensus CDS
    CCDS4334.1
    UniProtKB/Swiss-Prot
    O43513
    UniProtKB/TrEMBL
    E5RIE8, Q6IAZ5
    Related
    ENSP00000401046.1, ENST00000420343.1
    Conserved Domains (1) summary
    pfam05983
    Location:7 → 164
    Med7; MED7 protein

  2. NM_004270.5 → NP_004261.1  mediator of RNA polymerase II transcription subunit 7

    See identical proteins and their annotated locations for NP_004261.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AC010609, AF031383, AV711090, BQ011916
    Consensus CDS
    CCDS4334.1
    UniProtKB/Swiss-Prot
    O43513
    UniProtKB/TrEMBL
    E5RIE8, Q6IAZ5
    Related
    ENSP00000286317.5, ENST00000286317.6
    Conserved Domains (1) summary
    pfam05983
    Location:7 → 164
    Med7; MED7 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    157137424..157142865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    157656367..157661808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43513.1 GenPept UniProtKB/Swiss-Prot:O43513

Gene LinkOut

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