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cheA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946401, updated on 11-Sep-2024

Summary

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Official Symbol
cheA
Primary source
ECOCYC:EG10146
Locus tag
b1888
See related
ASAP:ABE-0006294
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1889
Summary
CheAS is required for polar localization of CheZ. [More information is available at EcoGene: EG10146]. The cheA gene encodes two forms, large and small, of an almost identical polypeptide. [More information is available at EcoCyc: EG10146].
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Genomic context

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Sequence:
NC_000913.3 (1973360..1975324, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene methyl-accepting chemotaxis protein Tar Neighboring gene chemotaxis protein CheW Neighboring gene motility protein B Neighboring gene motility protein A Neighboring gene ncRNA Neighboring gene DNA-binding transcriptional dual regulator FlhC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATP Binding as a Key Target for Control of the Chemotaxis Kinase. Jun SY, et al. J Bacteriol, 2020 Jun 9. PMID 32341073, Free PMC Article
  2. Strategies for identifying dynamic regions in protein complexes: Flexibility changes accompany methylation in chemotaxis receptor signaling states. Malik N, et al. Biochim Biophys Acta Biomembr, 2020 Sep 1. PMID 32304758, Free PMC Article
  3. Identification of a Kinase-Active CheA Conformation in Escherichia coli Chemoreceptor Signaling Complexes. Piñas GE, et al. J Bacteriol, 2019 Dec 1. PMID 31501279, Free PMC Article
  4. Conformational shifts in a chemoreceptor helical hairpin control kinase signaling in Escherichia coli. Gao Q, et al. Proc Natl Acad Sci U S A, 2019 Jul 30. PMID 31315979, Free PMC Article
  5. Regulatory Role of an Interdomain Linker in the Bacterial Chemotaxis Histidine Kinase CheA. Ding X, et al. J Bacteriol, 2018 May 15. PMID 29483161, Free PMC Article

See all (156) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Engineered chemotaxis core signaling units indicate a constrained kinase-off state.
    Title: Engineered chemotaxis core signaling units indicate a constrained kinase-off state.
  2. ATP Binding as a Key Target for Control of the Chemotaxis Kinase.
    Title: ATP Binding as a Key Target for Control of the Chemotaxis Kinase.
  3. Strategies for identifying dynamic regions in protein complexes: Flexibility changes accompany methylation in chemotaxis receptor signaling states.
    Title: Strategies for identifying dynamic regions in protein complexes: Flexibility changes accompany methylation in chemotaxis receptor signaling states.
  4. CheW truncated variants are able to drive chemotaxis behavior through activation and control of the CheA kinase. CheA control and networking activities reside in separate domains of CheW protein.
    Title: Truncated, Non-networking Versions of the Coupling Protein CheW Retain Chemoreceptor Control of Kinase CheA.
  5. It has been concluded that the dipped conformation of the CheA.P4 domain is critical to the kinase-active state in core signaling units.
    Title: Identification of a Kinase-Active CheA Conformation in Escherichia coli Chemoreceptor Signaling Complexes.
  6. Conformational shifts in a chemoreceptor helical hairpin control kinase signaling in Escherichia coli.
    Title: Conformational shifts in a chemoreceptor helical hairpin control kinase signaling in Escherichia coli.
  7. A model for signal transmission in chemotaxis signaling complexes in which the CheW-receptor interface plays the key role in conveying signaling-related conformational changes from receptors to the CheA kinase.
    Title: Noncritical Signaling Role of a Kinase-Receptor Interaction Surface in the Escherichia coli Chemosensory Core Complex.
  8. the interdomain linker is an active module that has the ability to impose regulatory effects on CheA activity
    Title: Regulatory Role of an Interdomain Linker in the Bacterial Chemotaxis Histidine Kinase CheA.
  9. Signaling complexes control CheA by altering its apparent rate constant of autophosphorylation.
    Title: Signaling complexes control the chemotaxis kinase by altering its apparent rate constant of autophosphorylation.
  10. Oxidized Aer activates CheA, whereas ASQ Aer reversibly inhibits CheA.
    Title: Bacterial Energy Sensor Aer Modulates the Activity of the Chemotaxis Kinase CheA Based on the Redox State of the Flavin Cofactor.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphorelay sensor kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphorelay sensor kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein histidine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein histidine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in bacterial-type flagellum-dependent swimming motility IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein modification process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphorelay signal transduction system IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of post-translational protein modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of bacterial-type flagellum-dependent cell motility IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of methyl accepting chemotaxis protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
chemotaxis protein CheA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1973360..1975324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_010283911.1 chemotaxis protein CheA [Escherichia coli str. K-12 substr. MG1655]

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A853WEC9

  2. NP_416402.2 chemotaxis protein CheA [Escherichia coli str. K-12 substr. MG1655]

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A418GHL6
    Conserved Domains (1) summary
    PRK10547
    Location:1 → 557
    PRK10547; chemotaxis protein CheA; Provisional
Nucleotide Protein
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