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CD34 CD34 molecule [ Homo sapiens (human) ]

Gene ID: 947, updated on 2-Nov-2024

Summary

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Official Symbol
CD34provided by HGNC
Official Full Name
CD34 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1662
See related
Ensembl:ENSG00000174059 MIM:142230; AllianceGenome:HGNC:1662
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Expression
Broad expression in placenta (RPKM 110.3), fat (RPKM 76.9) and 19 other tissues See more
Orthologs
mouse all
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Genomic context

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See CD34 in Genome Data Viewer
Location:
1q32.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (207880972..207911125, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (207127718..207157876, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (208054317..208084470, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:207979012-207980211 Neighboring gene MIR29B2 and MIR29C host gene Neighboring gene Sharpr-MPRA regulatory region 9321 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2453 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1775 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2454 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2455 Neighboring gene microRNA 29b-2 Neighboring gene uncharacterized LOC148696 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2456 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2457 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1776 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2459 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2458 Neighboring gene uncharacterized LOC107985253 Neighboring gene NANOG hESC enhancer GRCh37_chr1:208091350-208091981 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:208131807-208132308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:208132309-208132808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:208137516-208138045 Neighboring gene long intergenic non-protein coding RNA 2767 Neighboring gene plexin A2 Neighboring gene uncharacterized LOC105372887

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CD34 expression predicts an adverse outcome in patients with NPM1-positive acute myeloid leukemia. Dang H, et al. Hum Pathol, 2013 Oct. PMID 23701943
  2. Three-dimensional distribution patterns of CD34 antigen on nonactivated cord blood cells. Jung G, et al. Cytometry A, 2008 Jan. PMID 18061957
  3. Immunophenotypic peculiarities of mobilized stem (CD34+) cells in blood from patients with severe spinal cord injury. Tupitsyn NN, et al. J Biol Regul Homeost Agents, 2006 Jan-Jun. PMID 18088553
  4. CD34 expression in noncancerous liver tissue predicts multicentric recurrence of hepatocellular carcinoma. Tsuji N, et al. Dig Dis, 2013. PMID 24281022
  5. Regulation of cell shape and adhesion by CD34. Ohnishi H, et al. Cell Adh Migr, 2013 Sep-Oct. PMID 24036614, Free PMC Article

See all (366) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The value of immunohistochemical expression of SOX9 and CD34 in alopecia areata.
    Title: The value of immunohistochemical expression of SOX9 and CD34 in alopecia areata.
  2. Role of CD34 in calcification of human aortic valve interstitial cells from patients with aortic valve stenosis.
    Title: Role of CD34 in calcification of human aortic valve interstitial cells from patients with aortic valve stenosis.
  3. Expression of CD31, CD34, and smooth muscle actin (SMA) in endothelial cells of dental pulp vessels.
    Title: Expression of CD31, CD34, and smooth muscle actin (SMA) in endothelial cells of dental pulp vessels.
  4. Extracellular vesicle-derived TP53BP1, CD34, and PBX1 from human peripheral blood serve as potential biomarkers for the assessment and prediction of vascular aging.
    Title: Extracellular vesicle-derived TP53BP1, CD34, and PBX1 from human peripheral blood serve as potential biomarkers for the assessment and prediction of vascular aging.
  5. VEGFR2 and CD34 expression associated with longer survival in patients with pleural mesothelioma in the IFCT-GFPC-0701 MAPS phase 3 trial.
    Title: VEGFR2 and CD34 expression associated with longer survival in patients with pleural mesothelioma in the IFCT-GFPC-0701 MAPS phase 3 trial.
  6. C-type Lectin Domain Family 4 Member G (CLEC4G) Is a Negative Marker for CD34 in the Evolution of Liver Pathogenesis.
    Title: C-type Lectin Domain Family 4 Member G (CLEC4G) Is a Negative Marker for CD34 in the Evolution of Liver Pathogenesis.
  7. Expression of Markers Ki-67, Nestin, VEGF, CD34 and Apoptosis in Relatively Healthy Lung Tissue with Non-Changed and Metaplastic Bronchial Epithelium.
    Title: Expression of Markers Ki-67, Nestin, VEGF, CD34 and Apoptosis in Relatively Healthy Lung Tissue with Non-Changed and Metaplastic Bronchial Epithelium.
  8. A comparative study of the epiligament of the medial collateral and anterior cruciate ligaments in the human knee: Immunohistochemical analysis of CD 34, alpha-smooth muscle actin and vascular endothelial growth factor in relation to epiligament theory.
    Title: A comparative study of the epiligament of the medial collateral and anterior cruciate ligaments in the human knee: Immunohistochemical analysis of CD 34, α-smooth muscle actin and vascular endothelial growth factor in relation to epiligament theory.
  9. Circulating CD34+ cells of primary myelofibrosis patients contribute to myeloid-dominant hematopoiesis and bone marrow fibrosis in immunodeficient mice.
    Title: Circulating CD34+ cells of primary myelofibrosis patients contribute to myeloid-dominant hematopoiesis and bone marrow fibrosis in immunodeficient mice.
  10. Endothelial Progenitor Cell CD34(+) and CD133(+) Concentrations and Soluble HLA-G Concentrations During Pregnancy and in Cord Blood in Undifferentiated Connective Tissue Diseases Compared to Controls.
    Title: Endothelial Progenitor Cell CD34(+) and CD133(+) Concentrations and Soluble HLA-G Concentrations During Pregnancy and in Cord Blood in Undifferentiated Connective Tissue Diseases Compared to Controls.
Submit: New GeneRIF Correction See all GeneRIFs (326)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variants associated with general and MMR vaccine-related febrile seizures.
EBI GWAS Catalog
Genome-wide association analysis identifies multiple loci related to resting heart rate.
EBI GWAS Catalog
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
EBI GWAS Catalog
Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat enhances vIL-6-induced angiogenesis and tumorigenesis of fibroblasts and human endothelial cells, which correlates with upregulation of CD31, CD34, SMA, VEGF, b-FGF, and cyclin D1 expression PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables carbohydrate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sulfate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell motility IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cell-cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endothelial cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in endothelium development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in extracellular exosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glomerular endothelium development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in glomerular filtration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in hematopoietic stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in leukocyte migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mesangial cell-matrix adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in metanephric glomerular mesangial cell differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in paracrine signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gene expression IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of granulocyte colony-stimulating factor production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of granulocyte colony-stimulating factor production IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of odontogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of vasculogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in stem cell proliferation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in tissue homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transdifferentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in vascular wound healing IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in basal plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane IC
Inferred by Curator
more info
 PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
part_of glomerular endothelium fenestra ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
hematopoietic progenitor cell antigen CD34
Names
CD34 antigen
CD34 sialomucin

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025109.2 → NP_001020280.1  hematopoietic progenitor cell antigen CD34 isoform a precursor

    See identical proteins and their annotated locations for NP_001020280.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AA022917, AL356275, BC039146, M81104
    Consensus CDS
    CCDS31011.1
    UniProtKB/Swiss-Prot
    A8K664, P28906, Q15970, Q15971, Q5JTA3, Q5JTA4, Q9UJB1
    UniProtKB/TrEMBL
    A8KAG5
    Related
    ENSP00000310036.7, ENST00000310833.12
    Conserved Domains (1) summary
    pfam06365
    Location:190 → 384
    CD34_antigen; CD34/Podocalyxin family

  2. NM_001773.3 → NP_001764.1  hematopoietic progenitor cell antigen CD34 isoform b precursor

    See identical proteins and their annotated locations for NP_001764.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AA022917, AL356275, BC039146, M81104
    Consensus CDS
    CCDS31012.1
    UniProtKB/TrEMBL
    Q3C1E7
    Related
    ENSP00000348916.4, ENST00000356522.4
    Conserved Domains (1) summary
    pfam06365
    Location:190 → 328
    CD34_antigen; CD34/Podocalyxin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    207880972..207911125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    207127718..207157876 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339703.1 → XP_054195678.1  hematopoietic progenitor cell antigen CD34 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28906.2 GenPept UniProtKB/Swiss-Prot:P28906

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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