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T large T antigen;small T antigen [ Trichodysplasia spinulosa-associated polyomavirus ]

Gene ID: 9486897, updated on 18-Aug-2023

Summary

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Gene symbol
T
Gene description
large T antigen;small T antigen
Locus tag
TSaPV_gp4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Trichodysplasia spinulosa-associated polyomavirus (nat-host: Homo sapiens)
Lineage
Viruses; dsDNA viruses, no RNA stage; Polyomaviridae
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Genomic context

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Sequence:
NC_014361.1 (2528..5034, complement)

NC_014361.1Genomic Context describing neighboring genes Neighboring gene structural protein VP2 Neighboring gene structural protein VP3 Neighboring gene structural protein VP1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_014361.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of T Antigens, Including Middle T and Alternative T, Expressed by the Human Polyomavirus Associated with Trichodysplasia Spinulosa. van der Meijden E, et al. J Virol, 2015 Sep. PMID 26136575, Free PMC Article
  2. Emerging differential roles of the pRb tumor suppressor in trichodysplasia spinulosa-associated polyomavirus and Merkel cell polyomavirus pathogeneses. Wu JH, et al. J Clin Virol, 2016 Mar. PMID 26809132
  3. Discovery of a new human polyomavirus associated with trichodysplasia spinulosa in an immunocompromized patient. van der Meijden E, et al. PLoS Pathog, 2010 Jul 29. PMID 20686659, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings support important role of trichodysplasia spinulosa-associated polyomavirus (TSPyV)-mediated pRb deactivation in development of trichodysplasia spinulosa (TS); observation that pRb tumor suppressor is inactivated by TSPyV sT but not Merkel cell polyomavirus sT provides further insights into the distinct pathobiological mechanisms of Merkel cell carcinoma and TS
    Title: Emerging differential roles of the pRb tumor suppressor in trichodysplasia spinulosa-associated polyomavirus and Merkel cell polyomavirus pathogeneses.
  2. this study provides valuable new insights into polyomavirus T gene use and expression.
    Title: Characterization of T Antigens, Including Middle T and Alternative T, Expressed by the Human Polyomavirus Associated with Trichodysplasia Spinulosa.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
large T antigen;small T antigen

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_014361.1 Reference assembly

    Range
    2528..5034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_003800007.1 large T antigen [Trichodysplasia spinulosa-associated polyomavirus]

    See identical proteins and their annotated locations for YP_003800007.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3G1S4I4, E2ESL8
    Conserved Domains (1) summary
    PHA02624
    Location:1 → 672
    PHA02624; large T antigen; Provisional

  2. YP_003800008.1 small T antigen [Trichodysplasia spinulosa-associated polyomavirus]

    See identical proteins and their annotated locations for YP_003800008.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A068EUC0, E2ESL9, V5XW61
    Conserved Domains (3) summary
    pfam02380
    Location:92 → 186
    Papo_T_antigen; T-antigen specific domain
    smart00271
    Location:12 → 63
    DnaJ; DnaJ molecular chaperone homology domain
    PHA03102
    Location:7 → 163
    PHA03102; Small T antigen; Reviewed
Nucleotide Protein
Heading Accession and Version

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