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ZNF432 zinc finger protein 432 [ Homo sapiens (human) ]

Gene ID: 9668, updated on 14-Nov-2024

Summary

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Official Symbol
ZNF432provided by HGNC
Official Full Name
zinc finger protein 432provided by HGNC
Primary source
HGNC:HGNC:20810
See related
Ensembl:ENSG00000256087 MIM:620554; AllianceGenome:HGNC:20810
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables damaged DNA binding activity and protein-macromolecule adaptor activity. Involved in DNA damage response. Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in prostate (RPKM 5.4), testis (RPKM 3.4) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF432 in Genome Data Viewer
Location:
19q13.41
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (52031378..52048838, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55118576..55136058, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52534631..52552091, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15032 Neighboring gene uncharacterized LOC124904755 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15033 Neighboring gene zinc finger protein 614 Neighboring gene uncharacterized LOC112268244 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:52530119-52530889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15035 Neighboring gene zinc finger protein 160 pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:52568267-52569466 Neighboring gene zinc finger protein 841 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:52573383-52574582 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_51593 Neighboring gene zinc finger protein 616 Neighboring gene uncharacterized LOC124904799

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance. O'Sullivan J, et al. Nucleic Acids Res, 2023 Nov 10. PMID 37823600, Free PMC Article
  2. Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics. Wu AC, et al. J Allergy Clin Immunol, 2014 Mar. PMID 24280104, Free PMC Article
  3. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. Zhan X, et al. Anal Biochem, 2006 Jul 15. PMID 16777052
  4. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1998 Oct 30. PMID 9872452
  5. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance.
    Title: ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance.
  2. Inhaled corticosteroids appear to modulate the association of bronchodilator response with variant(s) in the ZNF432 gene among adults and children with asthma.
    Title: Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables damaged DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 432

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322284.2 → NP_001309213.1  zinc finger protein 432

    Status: VALIDATED

    Source sequence(s)
    AB018341, AC011468, BC002858, DA993118
    Consensus CDS
    CCDS12848.1
    UniProtKB/Swiss-Prot
    O94892
    Conserved Domains (5) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:259 → 636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:431 → 451
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:527 → 551
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001322285.1 → NP_001309214.1  zinc finger protein 432

    Status: VALIDATED

    Source sequence(s)
    AB018341, AC011468
    Consensus CDS
    CCDS12848.1
    UniProtKB/Swiss-Prot
    O94892
    Related
    ENSP00000470488.1, ENST00000594154.5
    Conserved Domains (5) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:259 → 636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:431 → 451
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:527 → 551
    zf-H2C2_2; Zinc-finger double domain

  3. NM_014650.4 → NP_055465.1  zinc finger protein 432

    See identical proteins and their annotated locations for NP_055465.1

    Status: VALIDATED

    Source sequence(s)
    AB018341, AC011468, BC002858, DB079612
    Consensus CDS
    CCDS12848.1
    UniProtKB/Swiss-Prot
    O94892
    Related
    ENSP00000221315.4, ENST00000221315.10
    Conserved Domains (5) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:259 → 636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:431 → 451
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:527 → 551
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    52031378..52048838 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451806.2 → XP_024307574.1  zinc finger protein 432 isoform X1

    Conserved Domains (2) summary
    COG5048
    Location:163 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:335 → 355
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    55118576..55136058 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322746.1 → XP_054178721.1  zinc finger protein 432 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O94892.1 GenPept UniProtKB/Swiss-Prot:O94892

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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