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HEVgp9 hypothetical protein [ Hepeviridae ]

Gene ID: 9725255, updated on 7-May-2023

Summary

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Gene symbol
HEVgp9
Gene description
hypothetical protein
Locus tag
HEVgp9
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Hepeviridae (strain: Xinjiang)
Lineage
Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes; Hepelivirales
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Genomic context

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Sequence:
NC_001434.1 (5109..5453)

NC_001434.1Genomic Context describing neighboring genes Neighboring gene polyprotein Neighboring gene capsid protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001434.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hepatitis E virus ORF3 is a functional ion channel required for release of infectious particles. Ding Q, et al. Proc Natl Acad Sci U S A, 2017 Jan 31. PMID 28096411, Free PMC Article
  2. Transcriptome Analysis of HepG2 Cells Expressing ORF3 from Swine Hepatitis E Virus to Determine the Effects of ORF3 on Host Cells. Xu K, et al. Biomed Res Int, 2016. PMID 27648443, Free PMC Article
  3. ORF3 of Hepatitis E Virus Inhibits the Expression of Proinflammatory Cytokines and Chemotactic Factors in LPS-Stimulated Human PMA-THP1 Cells by Inhibiting NF-κB Pathway. Lei Q, et al. Viral Immunol, 2016 Mar. PMID 26771290
  4. Characterization of antigenic domains and epitopes in the ORF3 protein of a Chinese isolate of avian hepatitis E virus. Zhao Q, et al. Vet Microbiol, 2013 Dec 27. PMID 24021883
  5. Virus host protein interaction network analysis reveals that the HEV ORF3 protein may interrupt the blood coagulation process. Geng Y, et al. PLoS One, 2013. PMID 23418552, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Via homophilic interactions ORF3 forms multimeric complexes associated with intracellular endoplasmic-reticulum-derived membranes. ORF3's ion channel function is evidenced by its ability to mediate ionic currents when expressed in Xenopus laevis oocytes. Several positions in ORF3 are critical for its formation of multimeric complexes, ion channel activity, and, ultimately, release of infectious particles.
    Title: Hepatitis E virus ORF3 is a functional ion channel required for release of infectious particles.
  2. we found that ORF3 protein downregulates TLR3-mediated NF-kappaB signaling via TRADD and RIP1. Our findings provide a new perspective on the cellular response in HEV infection and expand our understanding of the molecular mechanisms of Hepatitis E virus (HEV) pathogenesis in innate immunity.
    Title: The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1.
  3. Here, we report that the HEV X-domain directly interacts with the viral methyltransferase and the ORF3 proteins.
    Title: Identification of critical residues in Hepatitis E virus macro domain involved in its interaction with viral methyltransferase and ORF3 proteins.
  4. ORF3 plays a functional role in virus-cell interactions by affecting the expression of integral membrane protein and basement membrane proteins and by altering the process of apoptosis and lipid metabolism in host cells
    Title: Transcriptome Analysis of HepG2 Cells Expressing ORF3 from Swine Hepatitis E Virus to Determine the Effects of ORF3 on Host Cells.
  5. These results demonstrated that hepatitis E virus ORF3 attenuated lipopolysaccharide-induced cytokine production and chemotactic factors, predominantly by inhibiting various pattern recognition receptor-mediated NF-kappaB signaling pathways.
    Title: ORF3 of Hepatitis E Virus Inhibits the Expression of Proinflammatory Cytokines and Chemotactic Factors in LPS-Stimulated Human PMA-THP1 Cells by Inhibiting NF-κB Pathway.
  6. PSAP motif of OFR3 is required for hepatitis E virus exit and interaction with host TSG101.
    Title: Replacement of the hepatitis E virus ORF3 protein PxxP motif with heterologous late domain motifs affects virus release via interaction with TSG101.
  7. These results indicate that vp13, encoded by open reading frame 3, enhances RIG-I signaling and interferon-beta biosynthesis, which may play a role in hepatitis E virus invasion.
    Title: Enhancement of interferon induction by ORF3 product of hepatitis E virus.
  8. identified three antigenic domains at amino acids (aa) 1-28, 55-74 and 75-88 in which aa 75-88 was a dominant domain
    Title: Characterization of antigenic domains and epitopes in the ORF3 protein of a Chinese isolate of avian hepatitis E virus.
  9. Hepatitis E virus ORF3-induced miR-221/222 downregulation enhances p27(kip1) expression in HEK293 cells.
    Title: Identification of miR-221 and -222 as important regulators in genotype IV swine hepatitis E virus ORF3-expressing HEK 293 cells.
  10. Data suggest that the ORF3 protein is likely to lead to an imbalance of coagulation and fibrinolysis by interacting with host proteins and triggering the corresponding pathological processes.
    Title: Virus host protein interaction network analysis reveals that the HEV ORF3 protein may interrupt the blood coagulation process.
Submit: New GeneRIF Correction See all GeneRIFs (14)

General protein information

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Preferred Names
hypothetical protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001434.1 Reference assembly

    Range
    5109..5453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_003864075.1 hypothetical protein HEVgp9 [Hepeviridae]

    See identical proteins and their annotated locations for YP_003864075.1

    Status: PROVISIONAL

    Conserved Domains (1) summary
    pfam02444
    Location:1 → 114
    HEV_ORF1; Hepatitis E virus ORF-2 (Putative capsid protein)

Gene LinkOut

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