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Nlrp4f NLR family, pyrin domain containing 4F [ Mus musculus (house mouse) ]

Gene ID: 97895, updated on 2-Nov-2024

Summary

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Official Symbol
Nlrp4fprovided by MGI
Official Full Name
NLR family, pyrin domain containing 4Fprovided by MGI
Primary source
MGI:MGI:2145528
See related
Ensembl:ENSMUSG00000032999 AllianceGenome:MGI:2145528
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nalp4f; Nalp-kappa; C330026N02Rik
Summary
Predicted to enable molecular adaptor activity. Involved in several processes, including actin filament organization; in utero embryonic development; and positive regulation of embryonic development. Located in cell cortex. Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system gland; liver; and muscle tissue. Orthologous to human NLRP4 (NLR family pyrin domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Nlrp4f in Genome Data Viewer
Location:
13 B3; 13 34.45 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (65324925..65353530, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (65177111..65205716, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 9 subfamily S member 18 Neighboring gene predicted gene, 24130 Neighboring gene STARR-seq mESC enhancer starr_34836 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:65341962-65342145 Neighboring gene predicted gene, 36445 Neighboring gene STARR-seq mESC enhancer starr_34838 Neighboring gene STARR-seq mESC enhancer starr_34839 Neighboring gene predicted gene 10775

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The subcortical maternal complex protein Nlrp4f is involved in cytoplasmic lattice formation and organelle distribution. Qin D, et al. Development, 2019 Oct 18. PMID 31575650
  2. In silico identification and structural features of six new genes similar to MATER specifically expressed in the oocyte. Dadé S, et al. Biochem Biophys Res Commun, 2004 Nov 12. PMID 15474461
  3. Differences in gene expression between mouse and human for dynamically regulated genes in early embryo. Madissoon E, et al. PLoS One, 2014. PMID 25089626, Free PMC Article
  4. Ovarian gene expression in the absence of FIGLA, an oocyte-specific transcription factor. Joshi S, et al. BMC Dev Biol, 2007 Jun 13. PMID 17567914, Free PMC Article
  5. NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance. Zhang W, et al. Cell Rep, 2023 Dec 26. PMID 38060382

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of organelle localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NACHT, LRR and PYD domains-containing protein 4F
Names
NACHT, leucine rich repeat and PYD containing 4F
NALP, kappa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175290.4 → NP_780499.3  NACHT, LRR and PYD domains-containing protein 4F

    See identical proteins and their annotated locations for NP_780499.3

    Status: VALIDATED

    Source sequence(s)
    AK049352, AK135866, BC098479, CD541102, DV656119
    Consensus CDS
    CCDS49294.1
    UniProtKB/Swiss-Prot
    Q66X05
    UniProtKB/TrEMBL
    L7N1W9
    Related
    ENSMUSP00000041908.8, ENSMUST00000037372.8
    Conserved Domains (6) summary
    COG4886
    Location:630 → 871
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:636 → 926
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd08320
    Location:10 → 88
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    sd00033
    Location:689 → 713
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:718 → 745
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:147 → 315
    NACHT; NACHT domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    65324925..65353530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66X05.1 GenPept UniProtKB/Swiss-Prot:Q66X05

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