Deptor DEP domain containing MTOR-interacting protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Deptorprovided by MGI
Official Full Name: DEP domain containing MTOR-interacting proteinprovided by MGI
Primary source: MGI:MGI:2146322
See related: Ensembl:ENSMUSG00000022419 AllianceGenome:MGI:2146322
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Depdc6
Summary: Predicted to enable phosphatidic acid binding activity and protein serine/threonine kinase inhibitor activity. Predicted to be involved in several processes, including negative regulation of TOR signaling; negative regulation of cell size; and negative regulation of protein kinase activity. Predicted to be active in lysosomal membrane. Is expressed in brain and lung. Orthologous to human DEPTOR (DEP domain containing MTOR interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 11.6), subcutaneous fat pad adult (RPKM 8.1) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D1; 15 21.96 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (54975824..55122667)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (55112317..55259273)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells.
Title: The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells.
DEPTOR loss impairs brown adipocyte development in vitro but has limited impacts in mice.
Title: DEPTOR loss impairs brown adipocyte development in vitro but has limited impacts in mice.
High glucose-stimulated enhancer of zeste homolog-2 (EZH2) forces suppression of deptor to cause glomerular mesangial cell pathology.
Title: High glucose-stimulated enhancer of zeste homolog-2 (EZH2) forces suppression of deptor to cause glomerular mesangial cell pathology.
Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis.
Title: Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis.
miRNA-182/Deptor/mTOR axis regulates autophagy to reduce intestinal ischaemia/reperfusion injury.
Title: miRNA-182/Deptor/mTOR axis regulates autophagy to reduce intestinal ischaemia/reperfusion injury.
Helicobacter pylori promote inflammation and host defense through the cagA-dependent activation of mTORC1.
Title: Helicobacter pylori promote inflammation and host defense through the cagA-dependent activation of mTORC1.
DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals.
Title: DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals.
DEPTOR is a novel protein that functions in CD4(+) T cells to augment immunoregulation in vitro and in vivo
Title: DEPTOR modulates activation responses in CD4(+) T cells and enhances immunoregulation following transplantation.
findings demonstrate the roles and mechanisms of DEPTOR in the regulation of the renal physiology and pathology, and demonstrate that the loss of DEPTOR in the proximal tubules protects against cisplatin-induced acute kidney injury.
Title: Loss of DEPTOR in renal tubules protects against cisplatin-induced acute kidney injury.
Study revealed a novel function of DEPTOR in osteogenic differentiation by inhibiting MEG3-mediated activation of BMP4 signaling, which suggested that DEPTOR could be a therapeutic target for bone loss diseases and skeletal tissue regeneration.
Title: DEPTOR regulates osteogenic differentiation via inhibiting MEG3-mediated activation of BMP4 signaling and is involved in osteoporosis.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D15Ertd597e (e-PCR), detects polymorphism
- UniSTS:167171

MDB1127 (e-PCR)
- UniSTS:125048

D15Mit183 (e-PCR), detects polymorphism
- UniSTS:116433

RH125182 (e-PCR)
- UniSTS:162004

NoName (e-PCR)
- UniSTS:237296

D15Ertd336e (e-PCR), detects polymorphism
- UniSTS:167154

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidic acid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidic acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein kinase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of TORC2 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TORC2 signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC2 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell size	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DEP domain-containing mTOR-interacting protein

Names: DEP domain-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037937.4 → NP_001033026.1 DEP domain-containing mTOR-interacting protein isoform b

See identical proteins and their annotated locations for NP_001033026.1

Status: VALIDATED

Source sequence(s)

AC124659

Consensus CDS

CCDS27475.1

UniProtKB/TrEMBL

B2ZRS7, B2ZRS8

Related

ENSMUSP00000023056.8, ENSMUST00000023056.8

Conserved Domains (3) summary

cd00992
Location:327 → 391

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04441
Location:121 → 205

DEP_2_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.

cl02442
Location:29 → 105

DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
NM_145470.4 → NP_663445.2 DEP domain-containing mTOR-interacting protein isoform a

See identical proteins and their annotated locations for NP_663445.2

Status: VALIDATED

Source sequence(s)

AC124659

Consensus CDS

CCDS27474.1

UniProtKB/Swiss-Prot

Q3UM00, Q3UT08, Q570Y9

UniProtKB/TrEMBL

B2ZRS3, B2ZRS8

Related

ENSMUSP00000094167.4, ENSMUST00000096433.10

Conserved Domains (3) summary

cd00992
Location:339 → 403

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04441
Location:133 → 217

DEP_2_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.

cd04442
Location:36 → 117

DEP_1_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.