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GIT2 GIT ArfGAP 2 [ Homo sapiens (human) ]

Gene ID: 9815, updated on 2-Nov-2024

Summary

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Official Symbol
GIT2provided by HGNC
Official Full Name
GIT ArfGAP 2provided by HGNC
Primary source
HGNC:HGNC:4273
See related
Ensembl:ENSG00000139436 MIM:608564; AllianceGenome:HGNC:4273
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PKL; CAT2; CAT-2
Summary
This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]
Expression
Ubiquitous expression in spleen (RPKM 15.0), lymph node (RPKM 13.1) and 25 other tissues See more
Orthologs
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Genomic context

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See GIT2 in Genome Data Viewer
Location:
12q24.11
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (109929804..110000164, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (109905496..109975853, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (110367609..110434173, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 441, pseudogene Neighboring gene glycolipid transfer protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4845 Neighboring gene uncharacterized LOC124903012 Neighboring gene NANOG hESC enhancer GRCh37_chr12:110318928-110319429 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4846 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4847 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:110337802-110338642 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:110338643-110339483 Neighboring gene trichoplein keratin filament binding Neighboring gene ReSE screen-validated silencer GRCh37_chr12:110353916-110354160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:110358257-110358757 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:110361416-110362271 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:110362776-110363756 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:110363757-110364736 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:110370433-110371632 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:110384533-110385204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:110385205-110385876 Neighboring gene uncharacterized LOC124903013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4849 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6989 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4851 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6990 Neighboring gene Sharpr-MPRA regulatory region 2512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6991 Neighboring gene ankyrin repeat domain 13A Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:110460576-110461076 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6992 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:110465819-110467018 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:110480304-110480817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4852 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6993 Neighboring gene chromosome 12 open reading frame 76 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6995 Neighboring gene CRISPRi-validated cis-regulatory element chr12.3588 Neighboring gene uncharacterized LOC105369976 Neighboring gene Sharpr-MPRA regulatory region 13461

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. GIT2 deficiency attenuates inflammation-induced expression of pro-labor mediators in human amnion and myometrial cells†. Lim R, et al. Biol Reprod, 2019 Jun 1. PMID 30915469
  2. GIT proteins, A novel family of phosphatidylinositol 3,4, 5-trisphosphate-stimulated GTPase-activating proteins for ARF6. Vitale N, et al. J Biol Chem, 2000 May 5. PMID 10788515
  3. Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients. Oyama N, et al. Circ J, 2006 Mar. PMID 16501306
  4. The multifunctional GIT family of proteins. Hoefen RJ, et al. J Cell Sci, 2006 Apr 15. PMID 16598076
  5. An ADP-ribosylation factor GTPase-activating protein Git2-short/KIAA0148 is involved in subcellular localization of paxillin and actin cytoskeletal organization. Mazaki Y, et al. Mol Biol Cell, 2001 Mar. PMID 11251077, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries.
    Title: Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries.
  2. Long non-coding RNA MALAT1 promotes odontogenic differentiation of human dental pulp stem cells by impairing microRNA-140-5p-dependent downregulation of GIT2.
    Title: Long non-coding RNA MALAT1 promotes odontogenic differentiation of human dental pulp stem cells by impairing microRNA-140-5p-dependent downregulation of GIT2.
  3. GIT2 deficiency attenuates inflammation-induced expression of pro-labor mediators in human amnion and myometrial cellsdagger.
    Title: GIT2 deficiency attenuates inflammation-induced expression of pro-labor mediators in human amnion and myometrial cells†.
  4. our work identifies DOCK5 as a key regulator of epithelial invasion and metastasis, and demonstrates that suppression of DOCK5 by GIT2 represents a previously unappreciated mechanism for coordination of Rho and Rac GTPases.
    Title: The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion.
  5. we discuss recent findings in key physiological systems that exemplify current understanding of the function of this important regulatory complex. Further, we draw attention to gaps in crucial information that remain to be filled to allow a better understanding of the many roles of the GIT-PIX complex in health and disease
    Title: Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT-PIX complexes.
  6. Short-term EGF stimulation if of lung tumor cells can increase the interaction between RUSC2 and GIT2, prolonged stimulation leads to a decrease of their interaction through activating Rab35.
    Title: EGF-stimulated activation of Rab35 regulates RUSC2-GIT2 complex formation to stabilize GIT2 during directional lung cancer cell migration.
  7. GIT2 plays an important role in MRE11/ATM/H2AX-mediated DNA damage responses.
    Title: Nuclear GIT2 is an ATM substrate and promotes DNA repair.
  8. ADMA and L-arginine are substrates of human CAT2A, CAT2B, OCT2 and MATE1. Transport kinetics of CAT2A, CAT2B, and OCT2 indicate a low affinity, high capacity transport, which may be relevant for renal and hepatic elimination of ADMA or L-arginine
    Title: Transport of asymmetric dimethylarginine (ADMA) by cationic amino acid transporter 2 (CAT2), organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1).
  9. Zeb1 is regulated by the Arf GTPase-activating protein (GAP) Git2.
    Title: Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1.
  10. The expression level of lymphocyte GRK might show the severity of CHF, and ACEI treatment could reduce the level of GRK in CHF patients.
    Title: Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of the metabolic syndrome in Indian Asian men.
EBI GWAS Catalog
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC760, KIAA0148, DKFZp686G01261

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of ARF protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in focal adhesion HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ARF GTPase-activating protein GIT2
Names
ARF GAP GIT2
G protein-coupled receptor kinase interacting ArfGAP 2
G protein-coupled receptor kinase-interactor 2
GRK-interacting protein 2
Paxillin kinase linker
cool-associated, tyrosine phosphorylated protein 2
cool-interacting tyrosine-phosphorylated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029885.1 RefSeqGene

    Range
    5022..71586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001135213.3 → NP_001128685.1  ARF GTPase-activating protein GIT2 isoform 6

    See identical proteins and their annotated locations for NP_001128685.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two in-frame exons in the 3' coding region and includes an additional short in-frame exon in the central coding region, compared to isoform 1. The resulting isoform (6) is missing two internal fragments and includes a 2 residue insertion, compared to isoform 1.
    Source sequence(s)
    AA813937, BP871813, D63482
    Consensus CDS
    CCDS55884.1
    UniProtKB/TrEMBL
    R4GNG3
    Related
    ENSP00000391813.2, ENST00000457474.6
    Conserved Domains (5) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:268 → 296
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:563 → 674
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_001135214.3 → NP_001128686.1  ARF GTPase-activating protein GIT2 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks one in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (5) is missing one fragment but has the same N- and C-termini as isoform 1.
    Source sequence(s)
    AA813937, AF124491, BP871813, CR749340, D63482
    Consensus CDS
    CCDS44968.1
    UniProtKB/TrEMBL
    R4GNG3
    Related
    ENSP00000354282.5, ENST00000361006.9
    Conserved Domains (7) summary
    smart00105
    Location:2 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08518
    Location:266 → 294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:608 → 722
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:414 → 478
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]

  3. NM_001330153.2 → NP_001317082.1  ARF GTPase-activating protein GIT2 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting isoform (7) is shorter but has the same N- and C-termini as isoform 1.
    Source sequence(s)
    AA813937, AF124491, BE646544, BP871813, CR980157, D63482
    Consensus CDS
    CCDS81736.1
    UniProtKB/TrEMBL
    F8VXI9, R4GNG3
    Related
    ENSP00000448832.1, ENST00000551209.5
    Conserved Domains (6) summary
    smart00105
    Location:2 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08518
    Location:265 → 293
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:587 → 701
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]

  4. NM_001330154.2 → NP_001317083.1  ARF GTPase-activating protein GIT2 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks most 3' exons and has an alternate exon at the 3' end, as compared to variant 1. Isoform 8 is much shorter and has a different C-terminus than isoform 1.
    Source sequence(s)
    AC084876, AK222736, BM557270, BP871813
    Consensus CDS
    CCDS81737.1
    UniProtKB/TrEMBL
    B4E2E7, F8W822
    Related
    ENSP00000323833.9, ENST00000320063.10
    Conserved Domains (4) summary
    smart00105
    Location:2 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    pfam08518
    Location:266 → 293
    GIT_SHD; Spa2 homology domain (SHD) of GIT

  5. NM_014776.5 → NP_055591.2  ARF GTPase-activating protein GIT2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two exons in the coding region, as compared to variant 1. Isoform 3 is missing two fragments but has the same N- and C-termini as isoform 1.
    Source sequence(s)
    AA813937, AF124491, BP871813, D63482
    UniProtKB/TrEMBL
    R4GNG3
    Conserved Domains (6) summary
    smart00105
    Location:2 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08518
    Location:266 → 294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:558 → 672
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]

  6. NM_057169.5 → NP_476510.1  ARF GTPase-activating protein GIT2 isoform 1

    See identical proteins and their annotated locations for NP_476510.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA813937, AF124491, BP871813, D63482
    Consensus CDS
    CCDS9138.1
    UniProtKB/Swiss-Prot
    Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2
    UniProtKB/TrEMBL
    R4GNG3
    Related
    ENSP00000347464.3, ENST00000355312.8
    Conserved Domains (7) summary
    smart00105
    Location:2 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08518
    Location:266 → 294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:638 → 752
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:414 → 478
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]

  7. NM_057170.5 → NP_476511.1  ARF GTPase-activating protein GIT2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two exons and a portion of a third exon in the coding region, as compared to variant 1. The reading frame is maintained. Isoform 2 is missing internal 128 aa but has the same N- and C-termini as isoform 1.
    Source sequence(s)
    AA813937, AK308304, BC014223, BP871813, D63482
    Consensus CDS
    CCDS44969.1
    UniProtKB/TrEMBL
    R4GNG3
    Related
    ENSP00000447465.1, ENST00000553118.5
    Conserved Domains (6) summary
    smart00105
    Location:2 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    pfam08518
    Location:266 → 293
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:510 → 624
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam16559
    Location:414 → 450
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  8. NM_139201.3 → NP_631940.2  ARF GTPase-activating protein GIT2 isoform 4

    See identical proteins and their annotated locations for NP_631940.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks most 3' exons and has an alternate exon at the 3' end, as compared to variant 1. Isoform 4 is much shorter and has a different C-terminus than isoform 1.
    Source sequence(s)
    AC084876, AK222736, BM557270, BP871813
    Consensus CDS
    CCDS9139.1
    UniProtKB/TrEMBL
    B5BU58, Q6FI58
    Related
    ENSP00000450348.1, ENST00000547815.5
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:266 → 294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:414 → 465
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    pfam14203
    Location:246 → 284
    TTRAP; Putative tranposon-transfer assisting protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    109929804..110000164 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429924.1 → XP_047285880.1  ARF GTPase-activating protein GIT2 isoform X8

  2. XM_047429926.1 → XP_047285882.1  ARF GTPase-activating protein GIT2 isoform X10

  3. XM_047429925.1 → XP_047285881.1  ARF GTPase-activating protein GIT2 isoform X9

  4. XM_017020258.3 → XP_016875747.1  ARF GTPase-activating protein GIT2 isoform X6

    UniProtKB/TrEMBL
    R4GNG3

  5. XM_047429922.1 → XP_047285878.1  ARF GTPase-activating protein GIT2 isoform X3

  6. XM_047429923.1 → XP_047285879.1  ARF GTPase-activating protein GIT2 isoform X4

  7. XM_005253997.5 → XP_005254054.1  ARF GTPase-activating protein GIT2 isoform X1

    UniProtKB/TrEMBL
    R4GNG3
    Conserved Domains (7) summary
    smart00105
    Location:2 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08518
    Location:265 → 293
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:637 → 751
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:413 → 477
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]

  8. XM_006719712.5 → XP_006719775.1  ARF GTPase-activating protein GIT2 isoform X11

    Conserved Domains (6) summary
    smart00105
    Location:2 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08518
    Location:266 → 294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:475 → 589
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]

  9. XM_006719709.5 → XP_006719772.1  ARF GTPase-activating protein GIT2 isoform X7

    UniProtKB/TrEMBL
    R4GNG3
    Conserved Domains (6) summary
    smart00105
    Location:2 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08518
    Location:266 → 294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:588 → 702
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]

  10. XM_006719708.5 → XP_006719771.1  ARF GTPase-activating protein GIT2 isoform X5

    UniProtKB/TrEMBL
    R4GNG3
    Conserved Domains (7) summary
    smart00105
    Location:2 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08518
    Location:266 → 294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:593 → 707
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:414 → 463
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]

  11. XM_006719707.5 → XP_006719770.1  ARF GTPase-activating protein GIT2 isoform X2

    UniProtKB/TrEMBL
    R4GNG3
    Conserved Domains (7) summary
    smart00105
    Location:2 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08518
    Location:266 → 294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:623 → 737
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:414 → 463
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]

  12. XM_047429928.1 → XP_047285884.1  ARF GTPase-activating protein GIT2 isoform X15

  13. XM_047429927.1 → XP_047285883.1  ARF GTPase-activating protein GIT2 isoform X14

  14. XM_017020261.3 → XP_016875750.1  ARF GTPase-activating protein GIT2 isoform X12

    UniProtKB/TrEMBL
    B5BU58

  15. XM_006719713.5 → XP_006719776.1  ARF GTPase-activating protein GIT2 isoform X13

    UniProtKB/TrEMBL
    B5BU58
    Conserved Domains (6) summary
    smart00105
    Location:2 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08518
    Location:266 → 294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:414 → 449
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    109905496..109975853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373915.1 → XP_054229890.1  ARF GTPase-activating protein GIT2 isoform X8

  2. XM_054373917.1 → XP_054229892.1  ARF GTPase-activating protein GIT2 isoform X10

  3. XM_054373916.1 → XP_054229891.1  ARF GTPase-activating protein GIT2 isoform X9

  4. XM_054373913.1 → XP_054229888.1  ARF GTPase-activating protein GIT2 isoform X6

  5. XM_054373910.1 → XP_054229885.1  ARF GTPase-activating protein GIT2 isoform X3

  6. XM_054373911.1 → XP_054229886.1  ARF GTPase-activating protein GIT2 isoform X4

  7. XM_054373908.1 → XP_054229883.1  ARF GTPase-activating protein GIT2 isoform X1

  8. XM_054373918.1 → XP_054229893.1  ARF GTPase-activating protein GIT2 isoform X11

  9. XM_054373914.1 → XP_054229889.1  ARF GTPase-activating protein GIT2 isoform X7

  10. XM_054373912.1 → XP_054229887.1  ARF GTPase-activating protein GIT2 isoform X5

  11. XM_054373909.1 → XP_054229884.1  ARF GTPase-activating protein GIT2 isoform X2

  12. XM_054373922.1 → XP_054229897.1  ARF GTPase-activating protein GIT2 isoform X15

  13. XM_054373921.1 → XP_054229896.1  ARF GTPase-activating protein GIT2 isoform X14

  14. XM_054373919.1 → XP_054229894.1  ARF GTPase-activating protein GIT2 isoform X12

  15. XM_054373920.1 → XP_054229895.1  ARF GTPase-activating protein GIT2 isoform X13

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14161.2 GenPept UniProtKB/Swiss-Prot:Q14161

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