MELK maternal embryonic leucine zipper kinase [Homo sapiens (human)] - Gene

Summary

Official Symbol: MELKprovided by HGNC
Official Full Name: maternal embryonic leucine zipper kinaseprovided by HGNC
Primary source: HGNC:HGNC:16870
See related: Ensembl:ENSG00000165304 MIM:607025; AllianceGenome:HGNC:16870
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HPK38
Summary: Enables calcium ion binding activity; non-membrane spanning protein tyrosine kinase activity; and protein serine/threonine kinase activity. Involved in apoptotic process; cell population proliferation; and protein autophosphorylation. Located in cell cortex and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis (RPKM 5.2), lymph node (RPKM 4.4) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9p13.2

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (36572895..36677682)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (36595568..36700421)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (36572892..36677679)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MELK aggravates lung adenocarcinoma by regulating EZH2 ubiquitination and H3K27me3 histone methylation of LATS2.
Title: MELK aggravates lung adenocarcinoma by regulating EZH2 ubiquitination and H3K27me3 histone methylation of LATS2.
Exploration of MELK as a downstream of Del-1 and druggable targets in triple-negative breast cancer.
Title: Exploration of MELK as a downstream of Del-1 and druggable targets in triple-negative breast cancer.
Decoding the significant diagnostic and prognostic importance of maternal embryonic leucine zipper kinase in human cancers through deep integrative analyses.
Title: Decoding the significant diagnostic and prognostic importance of maternal embryonic leucine zipper kinase in human cancers through deep integrative analyses.
Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK-dependent manner.
Title: Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK‑dependent manner.
Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer.
Title: Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer.
ANKRD22 promotes glioma proliferation, migration, invasion, and epithelial-mesenchymal transition by upregulating E2F1-mediated MELK expression.
Title: ANKRD22 promotes glioma proliferation, migration, invasion, and epithelial-mesenchymal transition by upregulating E2F1-mediated MELK expression.
Differential Effects of Overexpression of Wild Type and Kinase-Dead MELK in Fibroblasts and Keratinocytes, Potential Implications for Skin Wound Healing and Cancer.
Title: Differential Effects of Overexpression of Wild Type and Kinase-Dead MELK in Fibroblasts and Keratinocytes, Potential Implications for Skin Wound Healing and Cancer.
Circular RNA MELK Promotes Chondrocyte Apoptosis and Inhibits Autophagy in Osteoarthritis by Regulating MYD88/NF-kappaB Signaling Axis through MicroRNA-497-5p.
Title: Circular RNA MELK Promotes Chondrocyte Apoptosis and Inhibits Autophagy in Osteoarthritis by Regulating MYD88/NF-κB Signaling Axis through MicroRNA-497-5p.
LncRNA OSTM1-AS1 acts as an oncogenic factor in Wilms' tumor by regulating the miR-514a-3p/MELK axis.
Title: LncRNA OSTM1-AS1 acts as an oncogenic factor in Wilms' tumor by regulating the miR-514a-3p/MELK axis.
Subtype-specific expression of MELK is partly due to copy number alterations in breast cancer.
Title: Subtype-specific expression of MELK is partly due to copy number alterations in breast cancer.

Submit: New GeneRIF Correction See all GeneRIFs (63)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat-peptide(48-60) inhibits AGC-family kinases (PKB, SGK1, S6K1, MSK1), CAMK-family kinases (CAMK1 and MELK) and a STE family kinase (MKK1)	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH25391 (e-PCR)
- UniSTS:52302

D9S1859 (e-PCR), detects polymorphism
- UniSTS:32964

RH118549 (e-PCR)
- UniSTS:137946

RH122388 (e-PCR)
- UniSTS:138485

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	TAS Traceable Author Statement more info	PubMed
involved_in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in hemopoiesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in neural precursor cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: maternal embryonic leucine zipper kinase

Names: pEg3 kinase; protein kinase Eg3; protein kinase PK38; tyrosine-protein kinase MELK

NP_001243614.1

EC 2.7.10.2

EC 2.7.11.1

NP_001243616.1

EC 2.7.10.2

EC 2.7.11.1

NP_001243617.1

EC 2.7.10.2

EC 2.7.11.1

NP_001243618.1

EC 2.7.10.2

EC 2.7.11.1

NP_001243619.1

EC 2.7.10.2

EC 2.7.11.1

NP_001243620.1

EC 2.7.10.2

EC 2.7.11.1

NP_001243621.1

EC 2.7.10.2

EC 2.7.11.1

NP_001243622.1

EC 2.7.10.2

EC 2.7.11.1

NP_055606.1

EC 2.7.10.2

EC 2.7.11.1

XP_011516378.1

EC 2.7.10.2

EC 2.7.11.1

XP_011516379.1

EC 2.7.10.2

EC 2.7.11.1

XP_011516382.1

EC 2.7.10.2

EC 2.7.11.1

XP_011516383.1

EC 2.7.10.2

EC 2.7.11.1

XP_011516384.1

EC 2.7.10.2

EC 2.7.11.1

XP_011516387.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280122.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280124.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280125.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280126.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280127.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280128.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280129.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280130.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280132.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280133.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280134.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280135.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280136.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280137.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280138.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280139.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280140.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280141.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280142.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280143.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280144.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280145.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280147.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280148.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280149.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280150.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280151.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280152.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280153.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280154.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280155.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280156.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280158.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280159.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280160.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280161.1

EC 2.7.10.2

EC 2.7.11.1

XP_047280162.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220272.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220273.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220274.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220275.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220276.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220277.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220278.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220279.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220280.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220281.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220282.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220283.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220284.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220285.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220286.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220287.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220288.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220289.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220290.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220291.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220292.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220293.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220294.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220295.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220296.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220297.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220298.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220299.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220300.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220301.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220302.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220303.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220304.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220305.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220306.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220307.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220308.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220309.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220310.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220311.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220312.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220313.1

EC 2.7.10.2

EC 2.7.11.1

XP_054220314.1

EC 2.7.10.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256685.2 → NP_001243614.1 maternal embryonic leucine zipper kinase isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AI590871, AK299164, BC014039, BP365611

Consensus CDS

CCDS59123.1

UniProtKB/TrEMBL

Q53GX0

Related

ENSP00000437804.1, ENST00000541717.4

Conserved Domains (4) summary

cd12198
Location:514 → 608

MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase

smart00220
Location:11 → 263

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14341
Location:281 → 332

UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins

cd14078
Location:7 → 263

STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
NM_001256687.2 → NP_001243616.1 maternal embryonic leucine zipper kinase isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AI590871, AK300761, BC014039, BP365611

Consensus CDS

CCDS59124.1

UniProtKB/TrEMBL

Q53GX0

Related

ENSP00000439792.1, ENST00000536860.5

Conserved Domains (4) summary

cd12198
Location:507 → 601

MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase

smart00220
Location:11 → 215

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14341
Location:233 → 284

UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins

cl21453
Location:7 → 215

PKc_like; Protein Kinases, catalytic domain
NM_001256688.2 → NP_001243617.1 maternal embryonic leucine zipper kinase isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two consecutive exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.

Source sequence(s)

AI590871, AK293284, BC014039, BP365611

Consensus CDS

CCDS59125.1

UniProtKB/TrEMBL

Q53GX0

Related

ENSP00000445452.1, ENST00000545008.5

Conserved Domains (4) summary

cd12198
Location:484 → 578

MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase

smart00220
Location:11 → 192

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14341
Location:210 → 261

UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins

cl21453
Location:7 → 192

PKc_like; Protein Kinases, catalytic domain
NM_001256689.2 → NP_001243618.1 maternal embryonic leucine zipper kinase isoform 5

See identical proteins and their annotated locations for NP_001243618.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) initiates translation at an alternate start codon and lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AB183427, AI590871, BP365611

Consensus CDS

CCDS59126.1

UniProtKB/TrEMBL

Q53GX0

Related

ENSP00000441596.1, ENST00000543751.5

Conserved Domains (4) summary

cd12198
Location:523 → 617

MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase

smart00220
Location:17 → 231

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14341
Location:249 → 300

UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins

cl21453
Location:7 → 231

PKc_like; Protein Kinases, catalytic domain
NM_001256690.2 → NP_001243619.1 maternal embryonic leucine zipper kinase isoform 6

See identical proteins and their annotated locations for NP_001243619.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) initiates translation at an alternate start codon and lacks two consecutive exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (6) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AB183428, AI590871, BP365611

Consensus CDS

CCDS59127.1

UniProtKB/TrEMBL

Q53GX0

Related

ENSP00000443550.1, ENST00000536329.5

Conserved Domains (4) summary

cd12198
Location:484 → 578

MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase

smart00220
Location:9 → 192

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14341
Location:210 → 261

UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins

cl21453
Location:10 → 192

PKc_like; Protein Kinases, catalytic domain
NM_001256691.2 → NP_001243620.1 maternal embryonic leucine zipper kinase isoform 7

See identical proteins and their annotated locations for NP_001243620.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) initiates translation at an alternate start codon and lacks two exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (7) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AI590871, AK293423, BP365611, W01871

UniProtKB/TrEMBL

B7Z1G6, Q53GX0

Conserved Domains (4) summary

cd12198
Location:475 → 569

MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase

smart00220
Location:17 → 183

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14341
Location:201 → 252

UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins

cl21453
Location:7 → 183

PKc_like; Protein Kinases, catalytic domain
NM_001256692.2 → NP_001243621.1 maternal embryonic leucine zipper kinase isoform 8

See identical proteins and their annotated locations for NP_001243621.1

Status: VALIDATED

Description

Transcript Variant: This variant (8) lacks three exons in the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (8) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AI590871, AK302374, DB368226

Consensus CDS

CCDS59128.1

UniProtKB/TrEMBL

B7Z450

Related

ENSP00000439184.1, ENST00000536987.5

Conserved Domains (4) summary

cd12198
Location:424 → 518

MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase

smart00220
Location:5 → 132

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14341
Location:150 → 201

UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins

cl21453
Location:5 → 132

PKc_like; Protein Kinases, catalytic domain
NM_001256693.2 → NP_001243622.1 maternal embryonic leucine zipper kinase isoform 9

See identical proteins and their annotated locations for NP_001243622.1

Status: VALIDATED

Description

Transcript Variant: This variant (9) lacks two consecutive exons in the 5' region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (9) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AI590871, AK301131, BP365611, W01871

UniProtKB/TrEMBL

B7Z450

Conserved Domains (3) summary

cd12198
Location:361 → 455

MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase

cd14341
Location:87 → 138

UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins

cl21453
Location:1 → 69

PKc_like; Protein Kinases, catalytic domain
NM_014791.4 → NP_055606.1 maternal embryonic leucine zipper kinase isoform 1

See identical proteins and their annotated locations for NP_055606.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AI590871, D79997, DB368226

Consensus CDS

CCDS6606.1

UniProtKB/Swiss-Prot

A6P3A7, A6P3A8, B1AMQ6, B7Z1E6, B7Z5M5, B7Z6Q7, B7Z6R8, B7Z6Y0, B7Z7Q1, D3DRP8, F5H0Y0, F5H2R4, F5H689, Q14680, Q7L3C3

UniProtKB/TrEMBL

Q53GX0

Related

ENSP00000298048.2, ENST00000298048.7

Conserved Domains (4) summary

cd12198
Location:555 → 649

MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase

smart00220
Location:11 → 263

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14341
Location:281 → 332

UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins

cd14078
Location:7 → 263

STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase

RNA

NR_046337.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (10) lacks an internal exon and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AI590871, AK296820, BC014039

Related

ENST00000627766.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000009.12 Reference GRCh38.p14 Primary Assembly

Range

36572895..36677682

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011518076.3 → XP_011516378.1 maternal embryonic leucine zipper kinase isoform X1

See identical proteins and their annotated locations for XP_011516378.1

UniProtKB/Swiss-Prot

A6P3A7, A6P3A8, B1AMQ6, B7Z1E6, B7Z5M5, B7Z6Q7, B7Z6R8, B7Z6Y0, B7Z7Q1, D3DRP8, F5H0Y0, F5H2R4, F5H689, Q14680, Q7L3C3

UniProtKB/TrEMBL

Q53GX0

Conserved Domains (4) summary

cd12198
Location:555 → 649

MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase

smart00220
Location:11 → 263

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14341
Location:281 → 332

UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins

cd14078
Location:7 → 263

STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
XM_047424171.1 → XP_047280127.1 maternal embryonic leucine zipper kinase isoform X4
XM_047424168.1 → XP_047280124.1 maternal embryonic leucine zipper kinase isoform X2
XM_047424180.1 → XP_047280136.1 maternal embryonic leucine zipper kinase isoform X7
XM_047424173.1 → XP_047280129.1 maternal embryonic leucine zipper kinase isoform X5
XM_047424192.1 → XP_047280148.1 maternal embryonic leucine zipper kinase isoform X12
XM_047424185.1 → XP_047280141.1 maternal embryonic leucine zipper kinase isoform X9
XM_011518082.3 → XP_011516384.1 maternal embryonic leucine zipper kinase isoform X3

See identical proteins and their annotated locations for XP_011516384.1

UniProtKB/TrEMBL

Q53GX0

Conserved Domains (4) summary

cd12198
Location:523 → 617

MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase

smart00220
Location:17 → 231

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14341
Location:249 → 300

UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins

cl21453
Location:7 → 231

PKc_like; Protein Kinases, catalytic domain
XM_047424182.1 → XP_047280138.1 maternal embryonic leucine zipper kinase isoform X8
XM_047424177.1 → XP_047280133.1 maternal embryonic leucine zipper kinase isoform X6
XM_047424195.1 → XP_047280151.1 maternal embryonic leucine zipper kinase isoform X13
XM_047424187.1 → XP_047280143.1 maternal embryonic leucine zipper kinase isoform X10

UniProtKB/TrEMBL

B7Z1G6
XM_047424204.1 → XP_047280160.1 maternal embryonic leucine zipper kinase isoform X17
XM_047424166.1 → XP_047280122.1 maternal embryonic leucine zipper kinase isoform X1

UniProtKB/Swiss-Prot

A6P3A7, A6P3A8, B1AMQ6, B7Z1E6, B7Z5M5, B7Z6Q7, B7Z6R8, B7Z6Y0, B7Z7Q1, D3DRP8, F5H0Y0, F5H2R4, F5H689, Q14680, Q7L3C3
XM_011518077.2 → XP_011516379.1 maternal embryonic leucine zipper kinase isoform X1

See identical proteins and their annotated locations for XP_011516379.1

UniProtKB/Swiss-Prot

A6P3A7, A6P3A8, B1AMQ6, B7Z1E6, B7Z5M5, B7Z6Q7, B7Z6R8, B7Z6Y0, B7Z7Q1, D3DRP8, F5H0Y0, F5H2R4, F5H689, Q14680, Q7L3C3

UniProtKB/TrEMBL

Q53GX0

Conserved Domains (4) summary

cd12198
Location:555 → 649

MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase

smart00220
Location:11 → 263

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14341
Location:281 → 332

UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins

cd14078
Location:7 → 263

STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
XM_047424170.1 → XP_047280126.1 maternal embryonic leucine zipper kinase isoform X4
XM_047424169.1 → XP_047280125.1 maternal embryonic leucine zipper kinase isoform X2
XM_047424179.1 → XP_047280135.1 maternal embryonic leucine zipper kinase isoform X7
XM_047424172.1 → XP_047280128.1 maternal embryonic leucine zipper kinase isoform X5
XM_047424191.1 → XP_047280147.1 maternal embryonic leucine zipper kinase isoform X12
XM_047424186.1 → XP_047280142.1 maternal embryonic leucine zipper kinase isoform X9
XM_047424200.1 → XP_047280156.1 maternal embryonic leucine zipper kinase isoform X16
XM_011518081.3 → XP_011516383.1 maternal embryonic leucine zipper kinase isoform X3

See identical proteins and their annotated locations for XP_011516383.1

UniProtKB/TrEMBL

Q53GX0

Conserved Domains (4) summary

cd12198
Location:523 → 617

MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase

smart00220
Location:17 → 231

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14341
Location:249 → 300

UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins

cl21453
Location:7 → 231

PKc_like; Protein Kinases, catalytic domain
XM_047424183.1 → XP_047280139.1 maternal embryonic leucine zipper kinase isoform X8
XM_047424176.1 → XP_047280132.1 maternal embryonic leucine zipper kinase isoform X6
XM_047424193.1 → XP_047280149.1 maternal embryonic leucine zipper kinase isoform X13
XM_047424188.1 → XP_047280144.1 maternal embryonic leucine zipper kinase isoform X10

UniProtKB/TrEMBL

B7Z1G6
XM_047424203.1 → XP_047280159.1 maternal embryonic leucine zipper kinase isoform X17
XM_047424197.1 → XP_047280153.1 maternal embryonic leucine zipper kinase isoform X14
XM_011518080.1 → XP_011516382.1 maternal embryonic leucine zipper kinase isoform X2

UniProtKB/TrEMBL

Q53GX0

Conserved Domains (3) summary

cd12198
Location:526 → 620

MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase

smart00220
Location:11 → 263

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14078
Location:7 → 263

STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
XM_047424178.1 → XP_047280134.1 maternal embryonic leucine zipper kinase isoform X7
XM_047424189.1 → XP_047280145.1 maternal embryonic leucine zipper kinase isoform X12
XM_047424184.1 → XP_047280140.1 maternal embryonic leucine zipper kinase isoform X9
XM_047424199.1 → XP_047280155.1 maternal embryonic leucine zipper kinase isoform X16
XM_047424181.1 → XP_047280137.1 maternal embryonic leucine zipper kinase isoform X8
XM_047424174.1 → XP_047280130.1 maternal embryonic leucine zipper kinase isoform X6
XM_047424194.1 → XP_047280150.1 maternal embryonic leucine zipper kinase isoform X13
XM_047424202.1 → XP_047280158.1 maternal embryonic leucine zipper kinase isoform X17
XM_047424196.1 → XP_047280152.1 maternal embryonic leucine zipper kinase isoform X14
XM_047424206.1 → XP_047280162.1 maternal embryonic leucine zipper kinase isoform X19
XM_011518085.2 → XP_011516387.1 maternal embryonic leucine zipper kinase isoform X11

UniProtKB/TrEMBL

Q53GX0

Conserved Domains (4) summary

cd12198
Location:472 → 566

MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase

smart00220
Location:1 → 180

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14341
Location:198 → 249

UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins

cl21453
Location:1 → 180

PKc_like; Protein Kinases, catalytic domain
XM_047424205.1 → XP_047280161.1 maternal embryonic leucine zipper kinase isoform X18
XM_047424198.1 → XP_047280154.1 maternal embryonic leucine zipper kinase isoform X15

Alternate T2T-CHM13v2.0

Genomic

NC_060933.1 Alternate T2T-CHM13v2.0

Range

36595568..36700421

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054364299.1 → XP_054220274.1 maternal embryonic leucine zipper kinase isoform X1

UniProtKB/Swiss-Prot

A6P3A7, A6P3A8, B1AMQ6, B7Z1E6, B7Z5M5, B7Z6Q7, B7Z6R8, B7Z6Y0, B7Z7Q1, D3DRP8, F5H0Y0, F5H2R4, F5H689, Q14680, Q7L3C3
XM_054364304.1 → XP_054220279.1 maternal embryonic leucine zipper kinase isoform X3
XM_054364317.1 → XP_054220292.1 maternal embryonic leucine zipper kinase isoform X8
XM_054364306.1 → XP_054220281.1 maternal embryonic leucine zipper kinase isoform X4
XM_054364314.1 → XP_054220289.1 maternal embryonic leucine zipper kinase isoform X7
XM_054364308.1 → XP_054220283.1 maternal embryonic leucine zipper kinase isoform X5
XM_054364322.1 → XP_054220297.1 maternal embryonic leucine zipper kinase isoform X10

UniProtKB/TrEMBL

B7Z1G6
XM_054364337.1 → XP_054220312.1 maternal embryonic leucine zipper kinase isoform X17
XM_054364301.1 → XP_054220276.1 maternal embryonic leucine zipper kinase isoform X2
XM_054364319.1 → XP_054220294.1 maternal embryonic leucine zipper kinase isoform X9
XM_054364329.1 → XP_054220304.1 maternal embryonic leucine zipper kinase isoform X13
XM_054364326.1 → XP_054220301.1 maternal embryonic leucine zipper kinase isoform X12
XM_054364311.1 → XP_054220286.1 maternal embryonic leucine zipper kinase isoform X6
XM_054364297.1 → XP_054220272.1 maternal embryonic leucine zipper kinase isoform X1

UniProtKB/Swiss-Prot

A6P3A7, A6P3A8, B1AMQ6, B7Z1E6, B7Z5M5, B7Z6Q7, B7Z6R8, B7Z6Y0, B7Z7Q1, D3DRP8, F5H0Y0, F5H2R4, F5H689, Q14680, Q7L3C3
XM_054364298.1 → XP_054220273.1 maternal embryonic leucine zipper kinase isoform X1

UniProtKB/Swiss-Prot

A6P3A7, A6P3A8, B1AMQ6, B7Z1E6, B7Z5M5, B7Z6Q7, B7Z6R8, B7Z6Y0, B7Z7Q1, D3DRP8, F5H0Y0, F5H2R4, F5H689, Q14680, Q7L3C3
XM_054364305.1 → XP_054220280.1 maternal embryonic leucine zipper kinase isoform X4
XM_054364302.1 → XP_054220277.1 maternal embryonic leucine zipper kinase isoform X2
XM_054364313.1 → XP_054220288.1 maternal embryonic leucine zipper kinase isoform X7
XM_054364307.1 → XP_054220282.1 maternal embryonic leucine zipper kinase isoform X5
XM_054364325.1 → XP_054220300.1 maternal embryonic leucine zipper kinase isoform X12
XM_054364320.1 → XP_054220295.1 maternal embryonic leucine zipper kinase isoform X9
XM_054364334.1 → XP_054220309.1 maternal embryonic leucine zipper kinase isoform X16
XM_054364303.1 → XP_054220278.1 maternal embryonic leucine zipper kinase isoform X3
XM_054364316.1 → XP_054220291.1 maternal embryonic leucine zipper kinase isoform X8
XM_054364310.1 → XP_054220285.1 maternal embryonic leucine zipper kinase isoform X6
XM_054364327.1 → XP_054220302.1 maternal embryonic leucine zipper kinase isoform X13
XM_054364321.1 → XP_054220296.1 maternal embryonic leucine zipper kinase isoform X10

UniProtKB/TrEMBL

B7Z1G6
XM_054364336.1 → XP_054220311.1 maternal embryonic leucine zipper kinase isoform X17
XM_054364331.1 → XP_054220306.1 maternal embryonic leucine zipper kinase isoform X14
XM_054364300.1 → XP_054220275.1 maternal embryonic leucine zipper kinase isoform X2
XM_054364312.1 → XP_054220287.1 maternal embryonic leucine zipper kinase isoform X7
XM_054364324.1 → XP_054220299.1 maternal embryonic leucine zipper kinase isoform X12
XM_054364318.1 → XP_054220293.1 maternal embryonic leucine zipper kinase isoform X9
XM_054364333.1 → XP_054220308.1 maternal embryonic leucine zipper kinase isoform X16
XM_054364315.1 → XP_054220290.1 maternal embryonic leucine zipper kinase isoform X8
XM_054364309.1 → XP_054220284.1 maternal embryonic leucine zipper kinase isoform X6
XM_054364328.1 → XP_054220303.1 maternal embryonic leucine zipper kinase isoform X13
XM_054364335.1 → XP_054220310.1 maternal embryonic leucine zipper kinase isoform X17
XM_054364330.1 → XP_054220305.1 maternal embryonic leucine zipper kinase isoform X14
XM_054364339.1 → XP_054220314.1 maternal embryonic leucine zipper kinase isoform X19
XM_054364323.1 → XP_054220298.1 maternal embryonic leucine zipper kinase isoform X11
XM_054364338.1 → XP_054220313.1 maternal embryonic leucine zipper kinase isoform X18
XM_054364332.1 → XP_054220307.1 maternal embryonic leucine zipper kinase isoform X15