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AI182371 expressed sequence AI182371 [ Mus musculus (house mouse) ]

Gene ID: 98870, updated on 10-Oct-2024

Summary

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Official Symbol
AI182371provided by MGI
Official Full Name
expressed sequence AI182371provided by MGI
Primary source
MGI:MGI:2138853
See related
Ensembl:ENSMUSG00000035875 AllianceGenome:MGI:2138853
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Biased expression in liver E18 (RPKM 25.4), liver adult (RPKM 24.5) and 2 other tissues See more
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Genomic context

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See AI182371 in Genome Data Viewer
Location:
2 B; 2 23.34 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (34971870..34991556, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (35081893..35101544, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene hemolytic complement Neighboring gene predicted gene 13449 Neighboring gene STARR-seq mESC enhancer starr_04276 Neighboring gene predicted gene, 39794 Neighboring gene STARR-positive B cell enhancer ABC_E4440 Neighboring gene centriolin Neighboring gene STARR-positive B cell enhancer ABC_E2616 Neighboring gene STARR-positive B cell enhancer ABC_E5906 Neighboring gene RAB14, member RAS oncogene family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Alpha-macroglobulins: structure, shape, and mechanism of proteinase complex formation. Sottrup-Jensen L. J Biol Chem, 1989 Jul 15. PMID 2473064
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
hemolytic complement-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243102.2 → NP_001230031.1  hemolytic complement-like isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, and it contains an alternate 3' exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL845534
    UniProtKB/TrEMBL
    Q505K6
    Related
    ENSMUSP00000154570.2, ENSMUST00000226631.2
    Conserved Domains (2) summary
    cd00017
    Location:269 → 337
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    pfam01835
    Location:134 → 228
    A2M_N; MG2 domain

  2. NM_001243103.2 → NP_001230032.1  hemolytic complement-like isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' exon, and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL845534
    UniProtKB/TrEMBL
    Q505K6
    Related
    ENSMUSP00000154033.2, ENSMUST00000226972.2
    Conserved Domains (2) summary
    cd00017
    Location:268 → 336
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    pfam01835
    Location:133 → 227
    A2M_N; MG2 domain

  3. NM_001379434.1 → NP_001366363.1  hemolytic complement-like isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AL845534
    UniProtKB/TrEMBL
    Q8BWN9
    Conserved Domains (3) summary
    cd00017
    Location:269 → 337
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    pfam01835
    Location:134 → 228
    A2M_N; MG2 domain
    pfam17790
    Location:32 → 128
    MG1; Macroglobulin domain MG1

  4. NM_001379435.1 → NP_001366364.1  hemolytic complement-like isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AL845534
    Conserved Domains (1) summary
    pfam17790
    Location:32 → 128
    MG1; Macroglobulin domain MG1

  5. NM_001379436.1 → NP_001366365.1  hemolytic complement-like isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AL845534
    Conserved Domains (1) summary
    pfam17790
    Location:28 → 127
    MG1; Macroglobulin domain MG1

  6. NM_001424716.1 → NP_001411645.1  hemolytic complement-like isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AL845534

  7. NM_001424717.1 → NP_001411646.1  hemolytic complement-like isoform 8 precursor

    Status: VALIDATED

    Source sequence(s)
    AL845534

  8. NM_001424718.1 → NP_001411647.1  hemolytic complement-like isoform 9 precursor

    Status: VALIDATED

    Source sequence(s)
    AL845534

  9. NM_178885.5 → NP_849216.2  hemolytic complement-like isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL845534
    Consensus CDS
    CCDS15958.2
    UniProtKB/TrEMBL
    A2AS37, Q8BWN9
    Related
    ENSMUSP00000037754.6, ENSMUST00000045776.5
    Conserved Domains (2) summary
    cd00017
    Location:268 → 336
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    pfam01835
    Location:133 → 227
    A2M_N; MG2 domain

RNA

  1. NR_166659.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL845534

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    34971870..34991556 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319351.3 → XP_017174840.1  hemolytic complement-like isoform X1

    UniProtKB/TrEMBL
    A0A2I3BRQ1
    Conserved Domains (3) summary
    cd00017
    Location:279 → 347
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    pfam17790
    Location:42 → 138
    MG1; Macroglobulin domain MG1
    pfam01835
    Location:145 → 238
    A2M_N; MG2 domain
Nucleotide Protein Strain
Heading Accession and Version

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