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SUPT7L SPT7 like, STAGA complex subunit gamma [ Homo sapiens (human) ]

Gene ID: 9913, updated on 10-Dec-2024

Summary

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Official Symbol
SUPT7Lprovided by HGNC
Official Full Name
SPT7 like, STAGA complex subunit gammaprovided by HGNC
Primary source
HGNC:HGNC:30632
See related
Ensembl:ENSG00000119760 MIM:612762; AllianceGenome:HGNC:30632
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPT7L; STAF65; SUPT7H; STAF65G; STAF65(gamma)
Summary
SUPT7L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 [PubMed 11564863]).[supplied by OMIM, Apr 2009]
Expression
Ubiquitous expression in brain (RPKM 10.8), spleen (RPKM 8.8) and 25 other tissues See more
Orthologs
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Genomic context

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See SUPT7L in Genome Data Viewer
Location:
2p23.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (27642568..27663614, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (27685653..27706702, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27873676..27886481, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15511 Neighboring gene coiled-coil domain containing 121 Neighboring gene GPN-loop GTPase 1 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:27875474-27876673 Neighboring gene solute carrier family 4 member 1 adaptor protein Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:27904532-27905731 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11303 Neighboring gene long intergenic non-protein coding RNA 1460 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11304

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. The transcriptional repression activity of STAF65γ is facilitated by promoter tethering and nuclear import of class IIa histone deacetylases. Hsieh FS, et al. Biochim Biophys Acta, 2014 Jul. PMID 24852358
  2. A new tumor-rejection antigen recognized by cytotoxic T lymphocytes infiltrating into a lung adenocarcinoma. Nishizaka S, et al. Cancer Res, 2000 Sep 1. PMID 10987294
  3. Recognition of a new ARTC1 peptide ligand uniquely expressed in tumor cells by antigen-specific CD4+ regulatory T cells. Wang HY, et al. J Immunol, 2005 Mar 1. PMID 15728473
  4. Transcriptional and subcellular regulation of the TRIP-Br family. Lai IL, et al. Gene, 2007 Feb 15. PMID 17141982
  5. Multivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damage. Gamper AM, et al. Mol Cell Biol, 2008 Apr. PMID 18250150, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our findings reveal a distinct role of STAF65gamma in nuclear import, transcriptional repression, and cell cycle regulation at high levels of expression, which is associated with poor clinical outcomes of lung adenocarcinoma.
    Title: The transcriptional repression activity of STAF65γ is facilitated by promoter tethering and nuclear import of class IIa histone deacetylases.
  2. optimal binding of STAGA to p53 involves interactions of STAGA subunits TAF9, GCN5, and ADA2b, respectively
    Title: Multivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damage.
  3. A novel peptide ligand recognized by tumor-specific CD4+ T regulatory (Treg) cells is a dominant peptide derived from the mutated ARTC1 gene. ARTC1 peptide-activated CD4+ Treg cells suppress proliferation and IL-2 secretion of melanoma-reactive T cells.
    Title: Recognition of a new ARTC1 peptide ligand uniquely expressed in tumor cells by antigen-specific CD4+ regulatory T cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0764, MGC90306

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in maintenance of protein location in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of RNA splicing NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of SAGA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SAGA complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
STAGA complex 65 subunit gamma
Names
SPT7 like, STAGA complex gamma subunit
SPTF-associated factor 65 gamma
STAF65gamma
STAGA complex 65 gamma subunit
adenocarcinoma antigen ART1
suppressor of Ty 7-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282729.2 → NP_001269658.1  STAGA complex 65 subunit gamma isoform a

    See identical proteins and their annotated locations for NP_001269658.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode isoform a.
    Source sequence(s)
    AB018307, AC074091, BC074000, CF528942, DA398215
    Consensus CDS
    CCDS42667.1
    UniProtKB/Swiss-Prot
    B4E3W3, O94864, Q6IB21, Q9H2T6
    Conserved Domains (1) summary
    smart00576
    Location:151 → 226
    BTP; Bromodomain transcription factors and PHD domain containing proteins

  2. NM_001282730.2 → NP_001269659.1  STAGA complex 65 subunit gamma isoform b

    See identical proteins and their annotated locations for NP_001269659.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. Both variants 3 and 4 encode isoform b.
    Source sequence(s)
    AB018307, AC074091, BC045638, CF528942, DA398215
    Consensus CDS
    CCDS62885.1
    UniProtKB/Swiss-Prot
    O94864
    Related
    ENSP00000384469.1, ENST00000405491.5
    Conserved Domains (1) summary
    smart00576
    Location:149 → 224
    BTP; Bromodomain transcription factors and PHD domain containing proteins

  3. NM_001282731.2 → NP_001269660.1  STAGA complex 65 subunit gamma isoform b

    See identical proteins and their annotated locations for NP_001269660.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. Both variants 3 and 4 encode isoform b.
    Source sequence(s)
    AB018307, AC074091, AF197954, BI755200, CF528942, DA001757
    Consensus CDS
    CCDS62885.1
    UniProtKB/Swiss-Prot
    O94864
    Conserved Domains (1) summary
    smart00576
    Location:149 → 224
    BTP; Bromodomain transcription factors and PHD domain containing proteins

  4. NM_001282732.2 → NP_001269661.1  STAGA complex 65 subunit gamma isoform c

    See identical proteins and their annotated locations for NP_001269661.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
    Source sequence(s)
    AB018307, AC074091, AK304889, CF528942
    Consensus CDS
    CCDS62886.1
    UniProtKB/Swiss-Prot
    O94864
    Related
    ENSP00000385218.2, ENST00000404798.6
    Conserved Domains (1) summary
    smart00576
    Location:16 → 91
    BTP; Bromodomain transcription factors and PHD domain containing proteins

  5. NM_014860.3 → NP_055675.1  STAGA complex 65 subunit gamma isoform a

    See identical proteins and their annotated locations for NP_055675.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Both variants 1 and 2 encode isoform a.
    Source sequence(s)
    AB018307, AC074091, AF197954, CF528942, DA398215
    Consensus CDS
    CCDS42667.1
    UniProtKB/Swiss-Prot
    B4E3W3, O94864, Q6IB21, Q9H2T6
    Related
    ENSP00000336750.5, ENST00000337768.10
    Conserved Domains (1) summary
    smart00576
    Location:151 → 226
    BTP; Bromodomain transcription factors and PHD domain containing proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    27642568..27663614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264672.5 → XP_005264729.1  STAGA complex 65 subunit gamma isoform X1

    See identical proteins and their annotated locations for XP_005264729.1

    UniProtKB/Swiss-Prot
    O94864
    Conserved Domains (1) summary
    smart00576
    Location:149 → 224
    BTP; Bromodomain transcription factors and PHD domain containing proteins

RNA

  1. XR_939750.4 RNA Sequence

  2. XR_007085624.1 RNA Sequence

  3. XR_007085611.1 RNA Sequence

  4. XR_007085617.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    27685653..27706702 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344774.1 → XP_054200749.1  STAGA complex 65 subunit gamma isoform X1

RNA

  1. XR_008486607.1 RNA Sequence

  2. XR_008486610.1 RNA Sequence

  3. XR_008486608.1 RNA Sequence

  4. XR_008486609.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O94864.1 GenPept UniProtKB/Swiss-Prot:O94864

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