Dux double homeobox [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Duxprovided by MGI
Official Full Name: double homeoboxprovided by MGI
Primary source: MGI:MGI:3703875
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dux4; Duxbl; AW822073; EG664783
Annotation information: not in current annotation release
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Genomic context

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Location:: 10 B4; 10

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dux activates metabolism-lactylation-MET network during early iPSC reprogramming with Brg1 as the histone lactylation reader.
Title: Dux activates metabolism-lactylation-MET network during early iPSC reprogramming with Brg1 as the histone lactylation reader.
The homeobox transcription factor DUXBL controls exit from totipotency.
Title: The homeobox transcription factor DUXBL controls exit from totipotency.
Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction.
Title: Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction.
Downstream events initiated by expression of FSHD-associated DUX4: Studies of nucleocytoplasmic transport, gammaH2AX accumulation, and Bax/Bak-dependence.
Title: Downstream events initiated by expression of FSHD-associated DUX4: Studies of nucleocytoplasmic transport, γH2AX accumulation, and Bax/Bak-dependence.
Systemic antisense therapeutics inhibiting DUX4 expression ameliorates FSHD-like pathology in an FSHD mouse model.
Title: Systemic antisense therapeutics inhibiting DUX4 expression ameliorates FSHD-like pathology in an FSHD mouse model.
iMyoblasts for ex vivo and in vivo investigations of human myogenesis and disease modeling.
Title: iMyoblasts for ex vivo and in vivo investigations of human myogenesis and disease modeling.
RIPK3-mediated cell death is involved in DUX4-mediated toxicity in facioscapulohumeral dystrophy.
Title: RIPK3-mediated cell death is involved in DUX4-mediated toxicity in facioscapulohumeral dystrophy.
Human miRNA miR-675 inhibits DUX4 expression and may be exploited as a potential treatment for Facioscapulohumeral muscular dystrophy.
Title: Human miRNA miR-675 inhibits DUX4 expression and may be exploited as a potential treatment for Facioscapulohumeral muscular dystrophy.
Functional study of distinct domains of Dux in improving mouse SCNT embryonic developmentdagger.
Title: Functional study of distinct domains of Dux in improving mouse SCNT embryonic development†.
Dux facilitates post-implantation development, but is not essential for zygotic genome activationdagger.
Title: Dux facilitates post-implantation development, but is not essential for zygotic genome activation†.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Targeted (2) 1 citation

General gene information

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Markers

Dux (e-PCR), detects polymorphism
- UniSTS:516165

Dux (e-PCR), detects polymorphism
- UniSTS:516166

Dux (e-PCR), detects polymorphism
- UniSTS:516167

Dux (e-PCR), detects polymorphism
- UniSTS:516168

Dux (e-PCR), detects polymorphism
- UniSTS:516169

Dux (e-PCR), detects polymorphism
- UniSTS:516170

Dux (e-PCR), detects polymorphism
- UniSTS:516171

Dux (e-PCR), detects polymorphism
- UniSTS:516172

Dux (e-PCR), detects polymorphism
- UniSTS:516173

Dux (e-PCR), detects polymorphism
- UniSTS:516174

Gene Ontology Provided by MGI

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: double homeobox

Names: homeobox protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081954.1 → NP_001075423.1 double homeobox

See identical proteins and their annotated locations for NP_001075423.1

Status: PROVISIONAL

Source sequence(s)

AM398149

UniProtKB/TrEMBL

A1JVI6, A1JVI7, A1JVI8

Conserved Domains (2) summary

smart00389
Location:112 → 162

HOX; Homeodomain

cd00086
Location:19 → 73

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.