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    NPY6R neuropeptide Y receptor Y6 (pseudogene) [ Homo sapiens (human) ]

    Gene ID: 4888, updated on 28-Oct-2024

    Summary

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    Official Symbol
    NPY6Rprovided by HGNC
    Official Full Name
    neuropeptide Y receptor Y6 (pseudogene)provided by HGNC
    Primary source
    HGNC:HGNC:7959
    See related
    Ensembl:ENSG00000293504 MIM:601770; AllianceGenome:HGNC:7959
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP2; Y2B; NPY1RL; NPY6RP
    Summary
    Predicted to enable neuropeptide binding activity and peptide YY receptor activity. Predicted to act upstream of or within neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in neuron projection and plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in heart (RPKM 55.5), duodenum (RPKM 9.3) and 5 other tissues See more
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    Genomic context

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    See NPY6R in Genome Data Viewer
    Location:
    5q31.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (137801193..137810751)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (138327615..138337173)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (137136882..137146440)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene kelch like family member 3 Neighboring gene microRNA 874 Neighboring gene MPRA-validated peak5486 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr5:137020129-137020374 Neighboring gene Sharpr-MPRA regulatory region 14679 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:137023227-137023961 Neighboring gene VISTA enhancer hs2181 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23184 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:137071377-137072045 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:137088711-137089402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23186 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:137090093-137090784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23187 Neighboring gene heterogeneous nuclear ribonucleoprotein A0 Neighboring gene uncharacterized LOC107986368 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23188 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23189 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:137199613-137199779 Neighboring gene PKD2L2 divergent transcript Neighboring gene myotilin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Molecular genetic analysis of a human neuropeptide Y receptor. The human homolog of the murine "Y5" receptor may be a pseudogene. Rose PM, et al. J Biol Chem, 1997 Feb 7. PMID 9013614
    2. Neuropeptide Y receptor gene y6: multiple deaths or resurrections? Starbäck P, et al. Biochem Biophys Res Commun, 2000 Oct 14. PMID 11027673
    3. Molecular characterization of a second mouse pancreatic polypeptide receptor and its inactivated human homologue. Gregor P, et al. J Biol Chem, 1996 Nov 1. PMID 8910373
    4. Inactivation of a novel neuropeptide Y/peptide YY receptor gene in primate species. Matsumoto M, et al. J Biol Chem, 1996 Nov 1. PMID 8910290
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    General gene information

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    Markers

    Clone Names

    • FLJ52676, FLJ53561

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables neuropeptide Y receptor activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in G protein-coupled receptor signaling pathway IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_002713.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC106791, DC357138
      Related
      ENST00000510937.3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      137801193..137810751
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      138327615..138337173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_024720.1: Suppressed sequence

      Description
      NG_024720.1: This RefSeq was permanently suppressed because it is now thought that this pseudogene is transcribed.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99463.1 GenPept UniProtKB/Swiss-Prot:Q99463

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials