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    NCAM1 neural cell adhesion molecule 1 [ Homo sapiens (human) ]

    Gene ID: 4684, updated on 3-Nov-2024

    Summary

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    Official Symbol
    NCAM1provided by HGNC
    Official Full Name
    neural cell adhesion molecule 1provided by HGNC
    Primary source
    HGNC:HGNC:7656
    See related
    Ensembl:ENSG00000149294 MIM:116930; AllianceGenome:HGNC:7656
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD56; NCAM; MSK39
    Summary
    This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein plays a role in the development of the nervous system by regulating neurogenesis, neurite outgrowth, and cell migration. This protein is also involved in the expansion of T lymphocytes, B lymphocytes and natural killer (NK) cells which play an important role in immune surveillance. This protein plays a role in signal transduction by interacting with fibroblast growth factor receptors, N-cadherin and other components of the extracellular matrix and by triggering signalling cascades involving FYN-focal adhesion kinase (FAK), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K). One prominent isoform of this gene, cell surface molecule CD56, plays a role in several myeloproliferative disorders such as acute myeloid leukemia and differential expression of this gene is associated with differential disease progression. For example, increased expression of CD56 is correlated with lower survival in acute myeloid leukemia patients whereas increased severity of COVID-19 is correlated with decreased abundance of CD56-expressing NK cells in peripheral blood. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2020]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Biased expression in brain (RPKM 90.3), adrenal (RPKM 31.4) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NCAM1 in Genome Data Viewer
    Location:
    11q23.2
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (112961420..113278436)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (112971836..113288890)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (112832142..113149158)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902801 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:112668663-112669340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:112669341-112670018 Neighboring gene uncharacterized LOC105369498 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:112692479-112693346 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:112693347-112694212 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:112748461-112748976 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:112752465-112752965 Neighboring gene uncharacterized LOC101928847 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:112832085-112832862 Neighboring gene RNA, U7 small nuclear 187 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:113017979-113018497 Neighboring gene NCAM1 antisense RNA1 Neighboring gene TTC12 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3908 Neighboring gene Sharpr-MPRA regulatory region 9915 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:113202304-113203503 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:113214693-113215892 Neighboring gene tetratricopeptide repeat domain 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Role of a neural cell adhesion molecule found in cerebrospinal fluid as a potential biomarker for epilepsy. Wang W, et al. Neurochem Res, 2012 Apr. PMID 22219127
    2. Excellent prognosis in a subset of patients with Ewing sarcoma identified at diagnosis by CD56 using flow cytometry. Ash S, et al. Clin Cancer Res, 2011 May 1. PMID 21467162
    3. Transgenic mice overexpressing the extracellular domain of NCAM are impaired in working memory and cortical plasticity. Brennaman LH, et al. Neurobiol Dis, 2011 Aug. PMID 21515372, Free PMC Article
    4. Hepatocellular carcinoma with progenitor cell features distinguishable by the hepatic stem/progenitor cell marker NCAM. Tsuchiya A, et al. Cancer Lett, 2011 Oct 1. PMID 21669487
    5. CD56 expression is associated with neuroectodermal differentiation in ameloblastomas: an immunohistochemical evaluation in comparison with odontogenic cystic lesions. Kusafuka K, et al. Med Mol Morphol, 2011 Jun. PMID 21717310

    See all (405) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD56/NCAM mediates cell migration of human NK cells by promoting integrin-mediated adhesion turnover.
      Title: CD56/NCAM mediates cell migration of human NK cells by promoting integrin-mediated adhesion turnover.
    2. Expression and Clinical Significance of CD30 and CD56 in Lymphoblastic Lymphoma: A Retrospective Analysis on Paraffin-Embedded Tissues by Immunohistochemistry.
      Title: Expression and Clinical Significance of CD30 and CD56 in Lymphoblastic Lymphoma: A Retrospective Analysis on Paraffin-Embedded Tissues by Immunohistochemistry.
    3. Plasma-derived extracellular vesicle surface markers CD45, CD326 and CD56 correlate with the stage of osteoarthritis: a primary study of a novel and promising diagnostic tool of the disease.
      Title: Plasma-derived extracellular vesicle surface markers CD45, CD326 and CD56 correlate with the stage of osteoarthritis: a primary study of a novel and promising diagnostic tool of the disease.
    4. A Comparative Study of CD56 and Smooth Muscle Actin Expression in Basal and Squamous Cell Carcinomas.
      Title: A Comparative Study of CD56 and Smooth Muscle Actin Expression in Basal and Squamous Cell Carcinomas.
    5. Investigation of CD56, ADAM17 and FGF21 Expressions in the Placentas of Preeclampsia Cases.
      Title: Investigation of CD56, ADAM17 and FGF21 Expressions in the Placentas of Preeclampsia Cases.
    6. [Prognostic Value of CD56 Expression in Newly Diagnosed Multiple Myeloma Patients and Its Related Factors].
      Title: [Prognostic Value of CD56 Expression in Newly Diagnosed Multiple Myeloma Patients and Its Related Factors].
    7. CD56-positive diffuse large B-cell lymphoma: comprehensive analysis of clinical, pathological, and molecular characteristics with literature review.
      Title: CD56-positive diffuse large B-cell lymphoma: comprehensive analysis of clinical, pathological, and molecular characteristics with literature review.
    8. Neural cell adhesion molecule 1 is a cellular target engaged plasma biomarker in demyelinating Charcot-Marie-Tooth disease.
      Title: Neural cell adhesion molecule 1 is a cellular target engaged plasma biomarker in demyelinating Charcot-Marie-Tooth disease.
    9. Retrospective Analysis of the Expression of CD56 in Multiple Myeloma with Bone-Related Extramedullary Diseases.
      Title: Retrospective Analysis of the Expression of CD56 in Multiple Myeloma with Bone-Related Extramedullary Diseases.
    10. Evaluating the prognostic value of CD56 in pediatric acute myeloid leukemia.
      Title: Evaluating the prognostic value of CD56 in pediatric acute myeloid leukemia.
    Submit: New GeneRIF Correction See all GeneRIFs (333)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: a genome-wide association and polygenic scoring study.
    EBI GWAS Catalog
    Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive families.
    EBI GWAS Catalog
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog
    Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in commissural neuron axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in epithelial to mesenchymal transition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of semaphorin-plexin signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    neural cell adhesion molecule 1
    Names
    antigen recognized by monoclonal antibody 5.1H11
    neural cell adhesion molecule, NCAM
    NP_000606.3
    NP_001070150.1
    NP_001229536.1
    NP_001229537.1
    NP_001373218.1
    NP_001373219.1
    NP_001373220.1
    NP_001373221.1
    NP_001387532.1
    NP_001387533.1
    NP_001387534.1
    NP_001387535.1
    NP_001387536.1
    NP_001387537.1
    NP_001387538.1
    NP_001387539.1
    NP_001387540.1
    NP_001387541.1
    NP_001387542.1
    NP_001387543.1
    NP_001387544.1
    NP_001387545.1
    NP_001387546.1
    NP_001387547.1
    NP_001387548.1
    NP_001387549.1
    NP_001387550.1
    NP_001387551.1
    NP_001387552.1
    NP_001387553.1
    NP_851996.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032036.2 RefSeqGene

      Range
      5002..322018
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000615.7 → NP_000606.3  neural cell adhesion molecule 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_000606.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks two alternate in-frame exons in the 3' coding region compared to variant 5. The resulting protein (isoform 1) is shorter compared to isoform 5.
      Source sequence(s)
      AK054570, AW131780, BC014205, BC047244, DA337649, S71824
      Consensus CDS
      CCDS73388.1
      Related
      ENSP00000484943.1, ENST00000531044.5
      Conserved Domains (8) summary
      cd05869
      Location:306 → 402
      IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
      smart00410
      Location:124 → 190
      IG_like; Immunoglobulin like
      cd00063
      Location:498 → 595
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:603 → 684
      fn3; Fibronectin type III domain
      pfam13927
      Location:411 → 483
      Ig_3; Immunoglobulin domain
      cd00096
      Location:211 → 216
      Ig; Ig strand A [structural motif]
      cd05865
      Location:20 → 116
      IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:211 → 307
      Ig; Immunoglobulin domain

    2. NM_001076682.4 → NP_001070150.1  neural cell adhesion molecule 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001070150.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region and uses an alternate splice site in the 3' coding region compared to variant 5. The resulting protein (isoform 3) is shorter and has a distinct C-terminus compared to isoform 5.
      Source sequence(s)
      AB209443, BC019845, BC047244, DA337649, S71824, X16841
      Consensus CDS
      CCDS73386.1
      Related
      ENSP00000480774.1, ENST00000621850.4
      Conserved Domains (7) summary
      cd05865
      Location:20 → 115
      Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1
      cd05869
      Location:306 → 402
      Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)
      smart00409
      Location:124 → 190
      IG; Immunoglobulin
      cd00063
      Location:498 → 595
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:638 → 719
      fn3; Fibronectin type III domain
      pfam13927
      Location:406 → 483
      Ig_3; Immunoglobulin domain
      cl11960
      Location:211 → 307
      Ig; Immunoglobulin domain

    3. NM_001242607.2 → NP_001229536.1  neural cell adhesion molecule 1 isoform 5 precursor

      See identical proteins and their annotated locations for NP_001229536.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) represents the longest transcript and encodes the longest protein (isoform 5).
      Source sequence(s)
      AK314589, AP000880, AP002853
      Consensus CDS
      CCDS73384.1
      UniProtKB/TrEMBL
      A0A087WWD4
      Related
      ENSP00000480132.1, ENST00000619839.4
      Conserved Domains (7) summary
      cd05865
      Location:20 → 115
      Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1
      smart00409
      Location:124 → 190
      IG; Immunoglobulin
      cd00063
      Location:534 → 631
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:639 → 720
      fn3; Fibronectin type III domain
      pfam13927
      Location:447 → 519
      Ig_3; Immunoglobulin domain
      cl11960
      Location:306 → 438
      Ig; Immunoglobulin domain
      cl25865
      Location:792 → 864
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)

    4. NM_001242608.2 → NP_001229537.1  neural cell adhesion molecule 1 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001229537.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks 2 alternate in-frame exons and uses an alternate splice site in the 3' coding region compared to variant 5. The resulting protein (isoform 4) is shorter and has a distinct C-terminus compared to isoform 5.
      Source sequence(s)
      AA029449, AB209443
      Consensus CDS
      CCDS73387.1
      Related
      ENSP00000481083.1, ENST00000621128.4
      Conserved Domains (8) summary
      cd05869
      Location:306 → 402
      IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
      smart00410
      Location:124 → 190
      IG_like; Immunoglobulin like
      cd00063
      Location:498 → 595
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:603 → 684
      fn3; Fibronectin type III domain
      pfam13927
      Location:411 → 483
      Ig_3; Immunoglobulin domain
      cd00096
      Location:211 → 216
      Ig; Ig strand A [structural motif]
      cd05865
      Location:20 → 116
      IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:211 → 307
      Ig; Immunoglobulin domain

    5. NM_001386289.1 → NP_001373218.1  neural cell adhesion molecule 1 isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, AP002853, FP884230
      Conserved Domains (8) summary
      cd05869
      Location:306 → 412
      IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
      smart00410
      Location:124 → 190
      IG_like; Immunoglobulin like
      cd00063
      Location:508 → 605
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:612 → 693
      fn3; Fibronectin type III domain
      pfam13927
      Location:421 → 493
      Ig_3; Immunoglobulin domain
      cd00096
      Location:211 → 216
      Ig; Ig strand A [structural motif]
      cd05865
      Location:20 → 116
      IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:211 → 307
      Ig; Immunoglobulin domain

    6. NM_001386290.1 → NP_001373219.1  neural cell adhesion molecule 1 isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, AP002853, FP884230
      Conserved Domains (7) summary
      cd05869
      Location:306 → 412
      IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
      smart00410
      Location:124 → 190
      IG_like; Immunoglobulin like
      pfam00041
      Location:612 → 693
      fn3; Fibronectin type III domain
      pfam13927
      Location:421 → 493
      Ig_3; Immunoglobulin domain
      cd00096
      Location:211 → 216
      Ig; Ig strand A [structural motif]
      cd05865
      Location:20 → 116
      IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:211 → 307
      Ig; Immunoglobulin domain

    7. NM_001386291.1 → NP_001373220.1  neural cell adhesion molecule 1 isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, AP002853, FP884230
      Consensus CDS
      CCDS91595.1
      UniProtKB/TrEMBL
      H7BYX6
      Related
      ENSP00000384055.3, ENST00000401611.6
      Conserved Domains (8) summary
      cd05869
      Location:306 → 402
      IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
      smart00409
      Location:124 → 190
      IG; Immunoglobulin
      cd00063
      Location:498 → 595
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:602 → 683
      fn3; Fibronectin type III domain
      pfam13927
      Location:411 → 483
      Ig_3; Immunoglobulin domain
      cd00096
      Location:211 → 216
      Ig; Ig strand A [structural motif]
      cd05865
      Location:20 → 116
      IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:211 → 307
      Ig; Immunoglobulin domain

    8. NM_001386292.1 → NP_001373221.1  neural cell adhesion molecule 1 isoform 9 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, AP002853, FP884230
      Conserved Domains (7) summary
      cd05869
      Location:306 → 402
      IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
      smart00409
      Location:124 → 190
      IG; Immunoglobulin
      pfam00041
      Location:602 → 683
      fn3; Fibronectin type III domain
      pfam13927
      Location:411 → 483
      Ig_3; Immunoglobulin domain
      cd00096
      Location:211 → 216
      Ig; Ig strand A [structural motif]
      cd05865
      Location:20 → 116
      IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:211 → 307
      Ig; Immunoglobulin domain

    9. NM_001400603.1 → NP_001387532.1  neural cell adhesion molecule 1 isoform 10 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, AP002853, FP884230

    10. NM_001400604.1 → NP_001387533.1  neural cell adhesion molecule 1 isoform 11 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, AP002853, FP884230

    11. NM_001400605.1 → NP_001387534.1  neural cell adhesion molecule 1 isoform 12 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, AP002853, FP884230

    12. NM_001400606.1 → NP_001387535.1  neural cell adhesion molecule 1 isoform 13 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, AP002853, FP884230

    13. NM_001400607.1 → NP_001387536.1  neural cell adhesion molecule 1 isoform 14 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, AP002853, FP884230

    14. NM_001400608.1 → NP_001387537.1  neural cell adhesion molecule 1 isoform 15 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, AP002853, FP884230

    15. NM_001400609.1 → NP_001387538.1  neural cell adhesion molecule 1 isoform 16 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, AP002853, FP884230

    16. NM_001400610.1 → NP_001387539.1  neural cell adhesion molecule 1 isoform 17 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, AP002853, FP884230

    17. NM_001400611.1 → NP_001387540.1  neural cell adhesion molecule 1 isoform 18 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, FP884230

    18. NM_001400612.1 → NP_001387541.1  neural cell adhesion molecule 1 isoform 19 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, AP002853, FP884230

    19. NM_001400613.1 → NP_001387542.1  neural cell adhesion molecule 1 isoform 20 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, FP884230

    20. NM_001400614.1 → NP_001387543.1  neural cell adhesion molecule 1 isoform 21 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, FP884230

    21. NM_001400615.1 → NP_001387544.1  neural cell adhesion molecule 1 isoform 22 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, AP002853, FP884230

    22. NM_001400616.1 → NP_001387545.1  neural cell adhesion molecule 1 isoform 23 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, AP002853, FP884230

    23. NM_001400617.1 → NP_001387546.1  neural cell adhesion molecule 1 isoform 24 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, AP002853, FP884230

    24. NM_001400618.1 → NP_001387547.1  neural cell adhesion molecule 1 isoform 25 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, AP002853, FP884230

    25. NM_001400619.1 → NP_001387548.1  neural cell adhesion molecule 1 isoform 26 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, FP884230

    26. NM_001400620.1 → NP_001387549.1  neural cell adhesion molecule 1 isoform 27 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, AP002853, FP884230

    27. NM_001400621.1 → NP_001387550.1  neural cell adhesion molecule 1 isoform 28 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, AP002853, FP884230

    28. NM_001400622.1 → NP_001387551.1  neural cell adhesion molecule 1 isoform 29 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, AP002853, FP884230

    29. NM_001400623.1 → NP_001387552.1  neural cell adhesion molecule 1 isoform 30 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, AP002853, FP884230

    30. NM_001400624.1 → NP_001387553.1  neural cell adhesion molecule 1 isoform 31 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000880, AP002853, FP884230

    31. NM_181351.5 → NP_851996.2  neural cell adhesion molecule 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_851996.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 5. The resulting protein (isoform 2) is shorter compared to isoform 5.
      Source sequence(s)
      AK054570, AW131780, BC014205, BC047244, DA337649, S71824
      Consensus CDS
      CCDS73385.1
      UniProtKB/Swiss-Prot
      A8K8T8, P13591, P13592, P13593, Q05C58, Q15829, Q16180, Q16209, Q59FL7, Q86X47, Q96CJ3
      Related
      ENSP00000318472.8, ENST00000316851.12
      Conserved Domains (7) summary
      cd05869
      Location:306 → 412
      IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
      smart00410
      Location:124 → 190
      IG_like; Immunoglobulin like
      pfam00041
      Location:613 → 694
      fn3; Fibronectin type III domain
      pfam13927
      Location:421 → 493
      Ig_3; Immunoglobulin domain
      cd00096
      Location:211 → 216
      Ig; Ig strand A [structural motif]
      cd05865
      Location:20 → 116
      IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:211 → 307
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      112961420..113278436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      112971836..113288890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13591.3 GenPept UniProtKB/Swiss-Prot:P13591

    Gene LinkOut

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